Tuberculin protein (hereinafter referred to as "PPD-S" in such a sense as a purified protein derivative) combined with glucuronic acid has less side effect and is chemically stable. The PPD-S combined with glucuronic acid is prepared by treating PPD-S with glucuronic acid metal salt, such as sodium glucuronate or potassium glucuronate, or with glucuronolactone. 4 Claims, No Drawings
A purified highly specific tuberculin, substantially free of protein, useful in the diagnosis of tuberculosis in humans and a process for preparing said tuberculin. Unlike known tuberculins, the aforesaid tuberculin is capable of being used to distinguish between tuberculosis-infected individuals and other individuals such as BCG-vaccinated individuals, and individuals infected with atypical mycobacteria of Runyon Groups I, II, III and IV. The average molecular weight of the purified highly specific tuberculin is lower than known tuberculins and in one embodiment of the purified highly specific tuberculin the average molecular weight is not more than 5000.
An agent for complexing sodium in aqueous solution comprises a glucuronic acid, specifically, beta-d-glucopyranosiduronic acid. The agent of the present invention furthermore includes the salts and esters of beta-d-glucopyranosiduronic acid. The salt of this acid is the triethanolamine salt of benzyl beta-d-glucopyranosiduronic acid. The ester of this acid is the benzyl ester. The agent of the present invention complexes sodium in aqueous solution in the pH range of living systems. Accordingly, it has use against such maladies as hypertension when taken internally and baldness when applied topically using a carrier in oil form.
