This invention relates to new cyclohexa-1,4-diene-1-acetic acids of the formula ##SPC1## Wherein R, R.sup.1 and R.sup.2 each is hydrogen or lower alkyl, and salts of these acids with bases, which are useful as anti-inflammatory agents.
2-(4-Isobutylphenyl)butyric acid and pharmaceutically acceptable salts thereof, processes for their production, and pharmaceutical compositions containing the same are disclosed. The compounds have antiinflammatory, analgesic and antipyretic properties.
A novel process for the preparation of tricyclo[6.2.2.0.sup.3,8 ]dodecane derivatives is presented. This novel process is applied to the synthesis of the odorant 4-acetyl-1,7,7-trimethyltricyclo[6.2.2.0.sup.3,8 ]-3-dodecene, also known as 4-aceto-6,8a-ethano-1,1,6-trimethyl-1,2,3,5,6,7,8,8a-octahydronaphthalene.
Certain substituted .alpha.-halo and .alpha.-mercaptophenylacetic acids and substituted phenylacetic acids having in .alpha.-position a sulfur-containing group, a cyano group, or an amino group, their substantially non-toxic esters, salts, and acid amides as well as 5-phenyl substituted 2-imino-4-oxothiazolidines and 5-phenyl substituted 2,4-dioxothiazolidines have a high anti-inflammatory, analgesic, and antipyretic activity, low toxicity, and/or a favorable therapeutic index with minor or no side-effects. Preferred compounds of this invention are .alpha., m-dichloro-p-cyclohexylphenylacetic acids and its esters and salts.
