The present adamantanecarboxylic acid derivatives of amino acids possess antibiotic activity against a variety of organisms. Thus, they are antibacterial, antiprotozoal, and antialgal agents. The compounds are prepared by the reaction of an adamantanecarbonyl halide, preferably the chloride, with an appropriate amino acid, dipeptide, or polypeptide.
A group of adamantyl containing intermediates is useful to prepare certain oligopeptides which improve kidney function. A representative species of this group is N-(1-adamantyl)-ethanoylproline.
Microorganisms, as for example, bacteria, fungi, molds and algae, can be inhibited by contact with an effective growth-inhibiting concentration of N-adamantyl gluconamide.
