Pharmaceutical compositions comprising a pharmaceutical carrier and a bis-chromonyl compound of the formula ##SPC1## And therapeutically acceptable salts, esters and amides thereof, in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are each selected from the group consisting of hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, hydroxyloweralkyl, haloloweralkyl, hydroxyloweralkoxy, loweralkoxyloweralkoxy and carboxyloweralkoxy; and X is selected from the group consisting of saturated and unsaturated, straight and branched hydrocarbon chains which may be interrupted by a member selected from the group consisting of benzene rings, dioxanyl, oxygen atoms and carbonyl groups, and which may be substituted by a member selected from the group consisting of halogen atoms, hydroxy groups and lower alkoxy groups are active to inhibit antigen-antibody reaction.
This application is a continuation of application Ser. No. 765,722, filed July 30, 1968 (now abandoned) which application is in turn a division of application Ser. No. 536,281, filed Mar. 22, 1966, now U.S. Pat. No. 3,419,578.
Priority Data
Mar 25, 1965 [GB] 12626/65 Dec 09, 1965 [GB] 52414/65
There is described a method of treatment of allergy to ingested allergens, which comprises per os administration of a daily dosage of from 20 to 4,000 mg of 1,3-bis(2-carboxychromon-5-yloxy)-2-hydroxypropane or a therapeutically acceptable salt thereof to a patient having such an allergy.
The present invention relates to methods of treating chronic skin disorders by externally applying to the skin compounds by the following formula ##STR1## and therapeutically acceptable salts, esters and amides thereof, wherein R.sub.1 through R.sub.6 and X are as hereinafter defined.
The present invention relates to methods of treating chronic skin disorders by externally applying to the skin compounds by the following formula ##STR1## and therapeutically acceptable salts, esters and amides thereof, wherein R.sub.1 through R.sub.6 and X are as hereinafter defined.
There is described a method of treatment of conditions of the gastro intestinal tract, in which conditions allergy or immune reactions play a contributory part, which method comprises per os administration of a compound of the formula I ##STR1## and therapeutically acceptable salts, esters and amides thereof, wherein X is a polymethylene chain containing 3 to 7 carbon atoms inclusive, which chain may be substituted by an --OH group, (as active ingredient), to a patient having such a condition.
There is described a method for the prevention or inhibition of an allergic reaction or tissue inflammation resulting from the placement of an endotracheal instrument or device, which method comprises administration by inhalation of an anti-allergy drug to a patient prior to the placement, during the placement, or while the instrument or device is in place. There are also described pharmaceutical mixtures comprising, as a first component, an anti-allergy drug and, as a second component, a substance conventionally administered by endotracheal intubation.
