Piperazines of the formula in which R is a straight or branched chain alkyl radical, which may be substituted by a hydroxyl, of one to seven carbon atoms, a cinnamyl radical, or a radical of the formula in which Z is hydroxy, alkoxy or a heterocyclic radical. The compounds are prepared by alkylating an N substituted piperazine with 2-bromo-6-methyl 5-heptene and then hydrating the reaction product in a sulfuric acid medium. The compounds may be incorporated with therapeutically acceptable carriers to make compositions exhibiting analeptic cardio-vascular effects.
Compounds of the formula ##STR1## wherein Z is --CH.sub.2 CH.sub.2 -- or --CH=CH--, and R is methyl, ethoxycarbonylmethyl or ##STR2## wherein ##STR3## is methylamino, n-propylamino, isopropylamino, dimethylamino, di(n-propyl)amino, morpholino, pyrrolidino or hexamethyleneimino. The compounds are prepared by reacting piperazine substituted with R, with 4'-bromomethyl-5,2'-spiro-dibenzocycloheptadi- (or tri)ene-(1',3') dioxolan. The compounds possess cough-suppressing, spasmolytic, analgesic, respiratory analeptic, hypotensive, vasodilatory, antiarythmic, antiulcerous, antihistamine, sedative, anti-inflammatory, diuretic and antiserotonine properties.
