Pharmaceutical compositions containing as active ingredients compounds of the formula ##SPC1## Wherein R.sub.1 is hydrogen, straight or branched alkyl of 1 to 6 carbon atoms, monohydroxy-(alkyl of 1 to 6 carbon atoms), or ##SPC2## Where R.sub.4 and R.sub.5 are each straight or branched alkyl of 1 to 4 carbon atoms, or, together with each other and the nitrogen atom to which they are attached, morpholino, pyrrolidino, piperidino or N'-methyl-piperazino, R.sub.2 is hydrogen or alkyl of 1 to 3 carbon atoms, R.sub.3 is hydrogen, straight or branched alkyl of 1 to 5 carbon atoms, or monohydroxy-(alkyl of 1 to 5 carbon atoms), X is oxygen, imino(--NH--) or methylimino(--NCH.sub.3 --), Y is oxygen, sulfur or imino, and n is 0 or 1, Or, to the extent that the compounds contain one or more basic nitrogen atoms, non-toxic acid addition salts thereof; and methods of using the compositions as bactericidal preparations against grampositive and gramnegative bacteria and against trichomonas.
Compounds of the formulas: ##STR1## wherein Het is an oxazole or oxazine moiety; X is O, S or SO, n is an integer from 3 to 9, Y is an aliphatic bridge; and the various R groups represent hydrogen or various substituents as described herein, are useful as antiviral agents, especially against picornaviruses. N-(Chloroalkyl)amide intermediates for the compounds of Formula I are also active as antiviral agents. Related compounds outside the scope of the above formulas are also disclosed.
