Acyl derivatives of 4-hydroxy-2H-1-benzothiopyran-3-carboxamide 1,1-dioxide having the following structural formulas are disclosed: ##SPC1## Wherein R.sub.1 and R.sub.2 are hydrogen, alkyl, aryl, aralkyl, alkoxy, halogen, cyano, nitro, trifluoromethyl, and the like. These compounds are useful as anti-inflammatory agents.