The invention relates to novel steroid compounds, more particularly to certain 7.alpha.-methyl-4-androstenes, 2.alpha.,7.alpha.-dimethyl-4-androstenes and their 19-nor-counterparts.
Various steroids which have a high affinity for rat ABP (androgen binding protein) and a low affinity for rat AR (androgen receptor) have been found to be useful as male contraceptives. Upon cessation of administration of the steroids of the present invention the male promptly regains normal fertility.
Prophylactic and therapeutic methods of treating pseudopregnancy and galactorrhea in mammals with 7.alpha.-methyltestosterones. Also, use of 7.alpha.-methyltestosterones in adjunct treatment of mastitis in mammals.