A process for the sulfenylation of N-phenylheterocyclic congeners with p-chlorosulfenyl chloride in a reaction-inert solvent at about 25.degree.-110.degree. C., said products being useful as coccidiostats or as intermediates for the preparation thereof.
A process for the preparation of 2(aryl)-as-triazine-3,5(2H,4H)-diones by the decarboxylation of the corresponding 6-carboxylic acid comprising contacting said acid with at least a 0.1 molar proportion of mercaptocarboxylic acid. Mercaptocarboxylic esters also bring about the decarboxylation, possibly by the in situ formation of the corresponding mercaptocarboxylic acid.
Acetylene substituted aromatic primary amines have been prepared by a method that yields a new class of compounds which by virtue of their stereo chemistry impart greater tractability and solubility to acetylene substituted polyimide oligomers. Compounds prepared by this method are useful as intermediates in the preparation of polyimide oligomers exhibiting lower melting points and improved solubilities.
The present invention provides novel compounds of the Formula I ##STR1## and prodrugs thereof, geometric and optical isomers thereof, and pharmaceutically acceptable salts of such compounds, prodrugs and isomers, wherein R.sup.1 to R.sup.8 and W are as described herein. Pharmaceutical compositions containing such compounds, prodrugs, isomers or pharmaceutically acceptable salts thereof, and methods, pharmaceutical compositions and kits for treating obesity, overweight condition, hyperlipidemia, thyroid disease, hypothyroidism, thyroid cancer and related disorders and diseases such as diabetes mellitus, atherosclerosis, hypertension, coronary heart disease, hypercholesteremia, depression, osteoporosis, cardiac arrhythmias, glaucoma and congestive heart failure are also provided.
The present invention provides novel compounds of the Formula I ##STR1## and prodrugs thereof, geometric and optical isomers thereof, and pharmaceutically acceptable salts of such compounds, prodrugs and isomers, wherein R.sup.1 to R.sup.8 and W are as described herein. Pharmaceutical compositions containing such compounds, prodrugs, isomers or pharmaceutically acceptable salts thereof, and methods, pharmaceutical compositions and kits for treating obesity, overweight condition, hyperlipidemia, thyroid disease, hypothyroidism, thyroid cancer and related disorders and diseases such as diabetes mellitus, atherosclerosis, hypertension, coronary heart disease, hypercholesteremia, depression, osteoporosis, cardiac arrhythmias, glaucoma and congestive heart failure are also provided.
