The excipient comprises hydroxy alkyl cellulose or hydroxy alkyl alkyl cellulose, wherein the average number of substituted moles of hydroxy group in glucose per anhydrous glucose unit is from 0.1 to 1.30; the average number of substituted moles of hydroxyalkyl groups per anhydrous glucose unit is from 0.05 to 1.00; and the average number of substituted moles of alkyl groups per anhydrous glucose unit is from 0 to 1.00. When the excipient is mixed with a medicament and the resultant mixture is compressed, hard, readily disintegratable tablets are produced.
This application is a continuation in part application of copending application Ser. No. 80203, filed Oct. 12, 1970 now abandoned, which claims the priority of Japanese applications 44-83102 of Oct. 17, 1969 and 45-24203 of Mar. 23, 1970.
Provided is an agent serving as a binder and a disintegrant for dry direct compression having a high binding property and fluidity. More specifically, provided are low-substituted hydroxypropyl cellulose having coiled fibers; an agent serving both as a binder and a disintegrant for dry direct compression and a solid preparation, each comprising the low-substituted hydroxypropyl cellulose; and a process for producing the low-substituted hydroxypropyl cellulose having coiled fibers.
The sugar-coated solid dosage forms have improved disintegrability even in a neutral medium after prolonged storage, with sugar-coating layers having excellent mechanical strengths. The coating layer that is in direct contact with the surface of the solid dosage form contains a water-insoluble hydroxypropyl cellulose with a relatively low content of hydroxypropoxy groups, say, from 4 to 16% by weight. The hydroxypropyl cellulose is used by being suspended in the coating syrup or mixed in the dusting powder for purposes of subcoating. It is also possible to use the hydroxypropyl cellulose in the form of suspension to form a smoothing coat.
This invention relates to a golf tee composed of water-soluble thermoplastic material and dispersed therein from about 1 to about 30% by weight, based on the weight of the golf tee, of a fertilizer and to a method of producing said golf tee by injection molding.
This invention relates to a fast release solid preparation, which comprises a solid dispersion composition containing dihydropyridien A compound uniformly dispersed in hydroxypropylmethyl cellulose as the dispersion medium, said dihydropyridine A compound being maintained in the amorphous state in said solid dispersion composition.
