Compounds of the formula ##SPC1## Wherein R.sup.1 is CN or an alkoxycarbonyl group, R.sup.2 is NH or an oxo group, n is an integer of from 3 to 6 inclusive and the ring A may be substituted by lower alkyl or phenyl are produced by reacting a compound of the formula ##SPC2## Wherein R.sup.3 is an alkoxyl or amino group and n and ring A are as defined above with a compound of the formula ##SPC3## Wherein R.sup.4 is an alkoxyl or amino group, R.sup.5 is CN or an alkoxycarbonyl group and R.sup.1 is as defined above. When R.sup.3 and R.sup.4 are both alkoxy the reaction is conducted in the presence of ammonia or an ammonia-producing substance. When R.sup.1 and R.sup.5 are both CN, R.sup.2 is NH. When one of R.sup.1 and R.sup.5 is CN and the other is an alkoxycarbonyl group, R.sup.2 is an oxo group. The compounds are useful as analgesics, antipyretics and antiinflammatories. The compounds where n is 3, 5 or 6 are novel.
Pyrida-(1,2A)-pyrimidine-derivatives and a process for preparing these compounds are disclosed. These compounds possess analgesic, anti-inflammatory, and anti-pyretic properties as well as the ability to depress the central nervous system.
Chemical compounds having an effect on the circulatory system have the formulas ##STR1## or a mixture thereof, or a pharmaceutically suitable acid-addition salt or quaternary salt thereof, wherein R is hydrogen or lower alkyl, R.sup.1 is lower alkyl, phenyl, carboxyl, lower alkoxycarbonyl, nitrile, carbamoyl or carbohydrazido, R.sup.2 is hydrogen or lower alkyl, and wherein the formula I R.sup.2 is hydrogen then R.sup.1 is other than nitrile, alkoxycarbonyl or propyl.
3 Substituted hexahydro-pyrimido[1, 2 a]azepines and quaternary derivatives, useful as antianginals are prepared. Specifically tested are 3 carboxylates and carbo hydrazides. 3 Cyano Carbamonyl and alkyl compounds are also disclosed.
New 3-substituted-2-oxo-tetrahydro-pyrrolo[1,2-a]pyrimidines of the formula (II) ##STR1## or a pharmaceutically acceptable acid addition or quaternary ammonium salts thereof are disclosed, wherein R is hydrogen or lower alkyl; R.sup.1 is lower alkyl, phenyl, carboxyl, lower alkoxycarbonyl, nitrile, carbamoyl, or carbohydrazido; and R.sup.2 is hydrogen or lower alkyl. The compounds exert a positive inotropic activity on the heart and have digitalis-like activity.
Nitrogen bridgehead compounds (pyrido-[1,2-a]-pyrimidine derivatives) which are useful intermediates in the making of known compounds of this class and which themselves possess PG-antagonist, analgesic, antiartheriosclerotic, tranquilizing and like pharmaceutical activity.
