A method for reducing the levels of cholesterol and other lipids in mammals, which comprises administering to said mammals an effective amount of a substance having the formula ##SPC1## Wherein R is selected from the group consisting of OH; NHCH.sub.2 COOH, and NHCH.sub.2 CH.sub.2 SO.sub.3 H; each X is hydrogen, each Y is hydroxy or acyloxy, and when taken together X and Y is oxo (O=); and the nontoxic pharmaceutically acceptable salts thereof.
This application is a continuation-in-part application of my previously filed, pending application, Ser. No. 259062, filed June 2, 1972 now abandoned, which is a continuation-in-part application of previously filed application, Ser. No. 126,296, filed Mar. 19, 1971 now abandoned.
A pharmaceutical oral controlled release composition comprising a multiplicity of microgranules or pellets, each of said pellets consisting of a core of active ingredient and binder and of a membrane applied upon said core, is described, wherein the active ingredient is a bile acid and the pellets have a particle-size of from 400 to 2000 microns.
The increase of bile flow and the decrease of the levels of lipids such as cholesterol and triglyceride is obtained in biological systems by utilizing specific 3 .alpha.,12.alpha. dihydroxy cholane derivatives and the non-toxic salts of these derivatives.
The present invention relates to a composition for oral use containing a bile acid as active principle, particularly suitable for the lysis of calculi of cholesterol origin, characterized in that it is in such a form as to yield up its active principle over a prolonged time period and is administered in a daily dose to be consumed in one taking.
The present invention relates to the use of a bile acid or bile salt fatty acid conjugate of general formula II W-X-G in which G is a bile acid or bile salt radical, which, if desired, is conjugated in position 24 with a suitable amino acid, W stands for one or two fatty acid radicals having 14-22 carbon atoms and X stands for a suitable bonding member or for a direct C.dbd.C bond between said bile acid or bile salt radical and the fatty acid(s) or of a pharmaceutical composition comprising same for the reduction of Cholesterol in blood, for the treatment of Fatty Liver, Hyperglycemia and Diabetes.
Polyol fatty acid polyesters are safe and effective agents for dissolving radiolucent gallstones when administered orally, either alone or, preferably, in conjunction with a litholytic bile acid.
