Methods employing as the essential ingredient, novel substituted xanthone carboxylic acid compounds in the treatment of the symptons of the asthmatic condition resulting from an antigen-antibody reaction. Methods for preparing these compounds and compositions and intermediates therein are also disclosed - 7 - (methylthio) - xanthone - 2 - carbonylic acid is illustrated as representative of the class.
Anti-allergic 4-hydroxy-3-nitro-pyrido[2,3-b]pyridines-2(1H)-ones are prepared by reacting a 3,4-dihydro-1,3-dioxo-1H-pyrido[2,3-d][1,3]oxazine (a 3-azaisatoic anhydride) with the carbanion resulting from the reaction of nitro acetic acid alkyl esters with a proton abstracting agent.
Nitro-indane-diones, their production, and pharmaceutical compositions and their administration in forms suitable for the prophylaxis of asthma, hayfever and rhinitis in amounts effective for oral, parenteral and insufflation administration for such forms. The compounds are nitro-indane-diones of the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 have certain designated meanings, obtained by nitration of a parent un-nitrated compound and wherein ring A contains 1 or 2 double bonds.
Pharmaceutical compositions having anti-allergy activity in which the active anti-allergy agents are certain 3-nitro-.alpha.-pyridones and their pharmaceutically acceptable salts formulated in one or more pharmaceutically acceptable carriers.
Substituted 2H-pyran-2,6(3H)-dione derivatives useful in the treatment of allergic conditions are prepared by reaction of 3,5-diacetyl-4,6-dihydroxy-2H-pyran-2-one with an appropriate aniline.
Compounds of the general formula: ##SPC1## Wherein X represents a 5-[1H]-tetrazolyl group, R.sub.1 represents a hydrogen atom, a halogen atom, a hydroxyl group or a group --OR.sub.2, (in which R.sub.2 may be a lower alkyl or alkenyl group containing from 1 to 6 carbon atoms optionally substituted by one or more hydroxy groups, an aryl group, an aryloxy group, an alkoxy group or a dialkylamino group) or a group --NR.sub.3 R.sub.4, in which R.sub.3 and R.sub.4 which may be the same or different, represent a hydrogen atom, a lower alkyl group containing from 1 to 6 carbon atoms, optionally substituted by a hydroxy group, or R.sub.3 and R.sub.4 together with the nitrogen atom may form a ring which may optionally be substituted with another heteroatom and pharmaceutically acceptable salts thereof. These compounds have useful immunological activity and inhibit the release of spasmogen mediators.
