A nonaqueous vehicle for oral pharmaceutical suspensions is described which has a satisfactory taste, low toxicity, good flow properties and is highly resistant to settling and caking of the suspended material. Such a vehicle is comprised principally of refined fractionated coconut oil, hydrogenated castor oil, lecithin, aluminum stearate and an oil isoluble excipient such as sucrose. This nonaqueous vehicle is useful for preparing ready-to-use oral pharmaceutical suspension of water degradable physiologically active agents.
Therapeutic liquid oral dosage formulations of propranolol hydrochloride are provided which contain lecithin and/or a basic amino acid to impart taste masking characteristics and/or contain a basic amino acid to impart anesthesia masking characteristics.
Permanent suspension dosage forms of drugs, particularly of the water-sensitive type, for administration without reconstitution are disclosed. The suspensions contain a drug dispersed in an anhydrous vegetable oil vehicle containing a saccharide as the suspending agent. These suspensions in dosage unit form exhibit long term stabilities, extended shelf lives, and excellent taste characteristics.
Novel pharmaceutical compositions of a cephalosporin in a prolonged release vehicle, comprising an oil and aluminium distearate, provide a prolonged duration of effective blood-plasma concentration of the cephalosporin after injection to animals.
A process for making a mixture of polyol and at least one additional reaction component for the manufacture of polyol fatty acid polyesters comprises co-milling the polyol and the additional reaction component. The co-milling reduces the particulate size of the polyol and the additional reaction component while creating particles which include an admixture of polyol and the additional reaction component. The co-milled mixture of polyol and additional reaction component can be used, for example, as a feed stream for the transesterfication reaction of the polyol to produce a polyol fatty acid polyester.
Cosmetic emulsions having a high internal phase ratio comprising an oil continuous phase, a water disperse phase, and an emulsifier combination of (i) aluminum and/or calcium stearate and (ii) a phosphated mono- and/or diglyceride; and method of preparing same.
