This invention relates to a topical, anti-inflammatory, pharmaceutical composition which comprises (a) a pharmaceutically acceptable solvent, e.g. propylene glycol and water, and (b) at least two corticosteroids chosen from those represented by formulas A through K defined hereinafter, each corticosteroid dissolved in said solvent at a concentration equal to the saturation solubility for each steroid. Other suitable pharmaceutical formulation additives may be added to prepare the desired type of formulation, e.g. cream, ointment, lotion, or gel. The invention includes a process for preparing the compositions and a method for treating inflamed skin conditions using the novel compositions.
The present invention comprises a composition, method of enhancing potency and method of delivering corticosteroids in a vehicle comprising at least two penetration enhancers, and solvents and emulsifiers. The propylene glycol and penetration enhancers are present in ratio to the total of the propylene glycol, penetration enhancers, and solvents and emulsifiers of at least about 0.70.
The present invention comprises a composition, method of enhancing potency and method of delivering corticosteroids in a vehicle comprising at least two penetration enhancers, and solvents and emulsifiers. The propylene glycol and penetration enhancers are present in ratio to the total of the propylene glycol, penetration enhancers, and solvents and emulsifiers of at least about 0.70.
The invention refers to the obtaining of the preparation for the treatment of the skin disease psoriasis. The object of the invention is a medicinal agent based on two corticosteroids, salicylates and antibiotics which clear the skin from psoriasis effectively, the most quickly and without endangering the integrity of healthy organs and skin regions and relapses approximate to zero point. The procedure according to the invention consists of the preparation of emulsion consisting of previously sterilized oil phase and water, to which are then added solutions of the active ingredients in such a way that all the phases are completed according to the order principle of ingredient stability to specified temperatures.
A composition for the treatment of psoriasis vulgaris, and a method for its preparation are described. The compound is made from the following ingredients: 6.alpha.,9.alpha.-difluoro-11.beta., 17.alpha.-dihidroxy-16.alpha.-methyl-21 trimethyl-acetoxy-1,4-pregnadiene-3,20 dione; (+)-17,21-dipropionyloxy-16.beta.-methyl-9.alpha.-fluoro-prednisolone; salicylic acid; tetracycline chloride; gentamycin sulfate; neomycin sulfate; trypsin; chymotrypsin; and bismuth. A method for the preparations of this composition is also disclosed. In this method, 6.alpha.,9.alpha.-difluoro-11.beta.,17.alpha.-dihidroxy-16.alpha.-methyl-2 1-trimethyl-acetoxy-1,4-pregnadiene-3,20 dione and (+)-17,21-dipropionyloxy-16.beta.-methyl-9.alpha.-fluoroprednisolone are first mixed together under intensive agitation. Salicyclic acid, tetracycline chloride, gentamycin sulfate and neomycin sulfate are then added. Next, trypsin, chymotrypsin and bismuth are added. Finally, the preparation is mixed into a neutral cream, ointment, etc., at which time it is ready for use. This unique composition of ingredients acting together achieves excellant results in the treatment psoriasis vulgaris.
A stable topical formulation with good active ingredient release characteristics, comprising at least one macrolide antibiotic which is lipophilized with at least one former of oppositely charged ions which is selected from the group consisting of alkyl sulfates, alkylsulfonates, and alkyl salicylates, RX, where R represents a linear and/or branched alkyl group with 6-32 C atoms, and X represents a sulfate, sulfonate, or salicylate group.
