The present invention relates to new pharmaceutical compositions comprising an .alpha.-receptor blocker, a .beta.-receptor blocker and a pharmaceutical carrier and to a method of using said compositions in the treatment of high blood pressure and angina pectoris.
CROSS-REFERENCES TO RELATED APPLICATION
This is a continuation-in-part application of our co-pending application Ser. No. 180,492, filed Sept. 14, 1971, now abandoned.
Novel 1-aryloxy-4-amino-2-butanols of the formula wherein Ar is 1-naphthyl, 2-naphthyl, indene-4(or 5-)yl, 3-(or 5-)chloro-2-pyridyl, phenyl, monosubstituted phenyl or di-substituted phenyl, R.sup.1 is lower alkyl, phenyl, phenylalkyl, 2-hydroxymethyl-2-propyl, adamantyl or lower-cycloalkyl, R.sup.2 is hydrogen or lower alkyl, wherein R.sup.1 and R.sup.2 together with the adjacent nitrogen form a heterocyclic residue and the pharmaceutically acceptable acid addition salts thereof having local anesthetic, beta-adrenergic blocking, antihypertensive and antiarrhythmic properties are disclosed. The compounds are prepared by reacting novel 1-aryloxy-4-chloro-2-butanols with amines. Methods for the preparation of the novel 1-aryloxy-4-chloro-2-butanol intermediates are also disclosed.
1-ISOPROPYLAMINO-3-[2-(2-NORBORNYL EXO)PHENOXY]PROPAN-2-OL, ITS 1-ISOPROPYLAMINO-3-[2-NORBORNYL ENDO)PHENOXY]PROPAN-2-OL ISOMER AND THEIR ACID ADDITION SALTS AND THEIR QUATERNARY AMMONIUM SALTS. These compounds can be used as beta-blocking agents against disorders of the cardiac rhythm, anti-anxiety and anti-hypertension medicaments.
Novel 1-aryloxy-4-amino-2-butanols of the formula wherein Ar is 1-naphthyl, 2-naphthyl, indene-4(or 5-)yl, 3-(or 5-)chloro-2-pyridyl, phenyl, monosubstituted phenyl or di-substituted phenyl, R.sup.1 is lower alkyl, phenyl, phenylalkyl, 2-hydroxymethyl-2-propyl, adamantyl or lower-cycloalkyl, R.sup.2 is hydrogen or lower alkyl, wherein R.sup.1 and R.sup.2 together with the adjacent nitrogen form a heterocyclic residue and the pharmaceutically acceptable acid addition salts thereof having local anesthetic, beta-adrenergic blocking, antihypertensive and antiarrhythmic properties are disclosed. The compounds are prepared by reacting novel 1-aryloxy-4-chloro-2-butanols with amines. Methods for the preparation of the novel 1-aryloxy-4-chloro-2-butanol intermediates are also disclosed.
1-{4-[2-(Cyclopropylmethoxy)-ethyl]-phenoxy}-3-isopropylamino-propan-2-ol and its pharmaceutically acceptable salts, in the form of a racemate or optical isomer, are useful as topical anti-glaucoma agents.
