Complexes of a semi-synthetic penicillin and an anion exchange resin cross-linked less than 4% and wherein the penicillin, with or without a non-complexed additional penicillin, is absorbed onto and in the ducts or channels in the resin particles substantially all of which have diameters between 20 .mu. and 250 .mu.. The semi-synthetic penicillin constitutes 35-65% of the complex. The complexes are formulated as pharmaceutical compositions which can be in tablet or syrup form. The penicillin is released rapidly and completely and is free of unpleasant taste.
Formulations of chewable pharmaceutical tablets for delivery of prescription pharmaceutical actives, non-prescription pharmaceutical actives, or over-the-counter actives comprise as an excipient an aggregate of coprocessed microcrystalline cellulose and a galaotomannan. Addition of these excipients imparts improved smell, taste, texture, and mouthfeel to the finished product.
Two, preferably three, layered orally administrable granules containing orally administrable penicillins have desirable properties such as elegance, freedom from dust and good reconstitution. They contain an inert core, preferably of sucrose, a penicillin/binder first layer and normally and preferably a final coating layer of conventional additives such as dyes, flavors etc.. Preferably the penicillin is amoxycillin trihydrate and the binder sucrose. The granules may be prepared by fluid bed granulation.
The invention disclosed is amoxicillin microencapsulated granules with activity densities greater than about 0.200 g/ml. These granules are unusually small having diameters less than about 1000 microns. The granules optionally have a taste mask coating, and are particularly useful in hand-held flowable material dispensers. A process for manufacturing such granules is also disclosed.
