April 20, 1976

15-Oxasteroids of the androstane, pregnane, estrane, and 19-norpregnane series are useful as hormonal agents.

3

April 20, 1976

05/528,384

November 29, 1974

549/334   549/457

C07D   307/00   (20060101)   C07D   307/77   (20060101)   C07J   73/00   (20060101)  

This is a division of application Ser. No. 217,956 filed Jan. 14, 1972 now U.S. Pat. No. 3,872,076.

260/346.2M   260/340.9  

5227375 - Aromatase inhibitors - Owned by Endorecherche, Inc. (CA) Novel aromatase inhibitors are disclosed for use in therapeutic preparations for treatment of estrogen-dependent diseases. The compounds are specified 7.alpha.-substituted androstanedione and androstenedione derivatives which show a strong inhibitory activity towards aromatase. The invention includes synthesis and pharmaceutical compositions of said compounds.