Method of controlling plant diseases, particularly late blight and apple scab, with aminodicyanopyrazines, such as 2-t-butylamino-3-chloro-5,6-dicyanopyrazine; and agricultural compositions containing these compounds.
This invention provides a method of inhibiting aromatase and treating or preventing estrogen-dependent diseases in mammals by administering certain amine derivatives.
Novel 2,3-dicyanopyrazine derivatives of the formula ##STR1## wherein A represents a hydrogen atom, a lower alkyl group, an unsubstituted or substituted phenyl group, a benzyl group, or a group of the formula --ZR.sub.1 in which Z represents an oxygen or sulfur atom and R.sub.1 represents an unsubstituted or substituted lower alkyl group, a lower alkenyl group, a lower alkynyl group, an unsubstituted or substituted phenyl group, or an unsubstituted or substituted benzyl group; and B represents a halogen atom, an alkyl group containing at least 3 carbon atoms, a phenyl group having a substituent at the ortho- and/or meta-position of the benzene ring, a group of the formula ZR.sub.1 in which Z and R.sub.1 are as defined, or a group of the formula ##STR2## in which R.sub.2 and R.sub.3, independently from each other, represent a hydrogen atom, an unsubstituted or substituted lower alkyl group, a lower alkenyl group, a cycloalkyl group, an unsubstituted or substituted phenyl group, or an unsubstituted or substituted benzyl group, with the proviso that R.sub.2 and R.sub.3 do not represent a hydrogen atom at the same time, and R.sub.2 and R.sub.3 together may form a 3- to 7-membered heterocyclic ring together with the nitrogen atom to which they are bonded, said heterocyclic ring optionally containing an additional hetero atom; and processes for production thereof. These compounds have high herbicidal activity, and are useful as active ingredients of herbicides.
Antimicrobial compounds of the formula: ##STR1## wherein: Hal is bromine or chlorine; and R is halo; mono- or di-substituted mono- or diloweralkylamino wherein the loweralkyl substituents are hydroxy or loweralkanoyloxy; 4-morpholino; thiocyano; mercapto; straight or branched chain C.sub.1-8 alkylthio; mono- or di-substituted loweralkylthio wherein the substituents are hydroxy, amino, loweralkanoylamino, or loweralkoxycarbonyl; arylthio; loweralkylsulfoxy; or loweralkylsulfonyl; R.sup.1 is hydrogen; or loweralkyl; R.sup.2 is (CH.sub.2).sub.n COOR.sup.a, where R.sup.a is hydrogen, loweralkyl, or benzyl; and n is 1 to 3; R.sup.1 and R.sup.2 are taken together with an oxygen or nitrogen atom or form morpholino, piperazinyl, or piperazinyl which is N-loweralkyl substituted; R.sup.3 is hydrogen; straight or branched C.sub.1-8 alkyl; aryl; aryl substituted with up to two members selected from the group consisting of C.sub.1-3 alkyl, C.sub.1-3 alkoxy, halo, and mono- or di-C.sub.1-3 alkyl substituted amino; heteroaryl; formylC.sub.2-4 alkenyl; or C.sub.2-4 alkenyl; and R.sup.4 is straight or branched C.sub.1-8 alkyl; loweralkoxy; hydroxy; loweralkoxycarbonylmethyl; benzyl; or benzyl substituted with up to two members selected from the group consisting of halo, loweralkyl, and loweralkoxy; are useful in various agricultural and industrial applications.
