An intrauterine contraceptive device comprising an elongated shank having divergent convoluted portions at its distal end, said convoluted portions being generally sinusoidal in nature, said device having incorporated in said shank a permanent magnet and having a substantial portion of its surface covered with a biologically inert, silicone elastomeric material which may contain an analgaesic or anti-fertility agent which is gradually released in utero. In a preferred embodiment of the invention, the proximal end of the shank contains a pair of downwardly extending divergent, resilient legs which tend to prevent inadvertent expulsion of the device. In another preferred embodiment, the lower end of the device is formed with one or more small refillable containers for certain types of medication which are released gradually into the vagina and the lower end of the uterus over a prolonged period of time for the prevention of such venereal diseases as gonorrhea, syphilis, trichomonas vaginalis and moniliasis. In the process of the invention, venereal diseases, such as gonorrhea, syphilis, trichomonas vaginalis and moniliasis, are prevented by the direct administration in the vagina continuously over a prolonged period of time of at least about 30 days to maintain in the vagina the minimum inhibitory concentration of a safe medication which will prevent, or kill the growth of the venereal disease-causing organism.
REFERENCE TO RELATED CASES
This application is a continuation-in-part of U.S. application Ser. No. 621,958, filed 10/04/75, now U.S. Pat. No. 3,996,933; which is a continuation-in-part of Ser. No. 432,435, filed 01/11/74, now abandoned; which is a continuation-in-part of Ser. No. 294,200, filed 10/02/72, now abandoned. This application is also a continuation-in-part of Ser. No. 515,574, filed 10/17/74, now abandoned; which is a continuation-in-part of Ser. No. 294,200 filed 10/02/72, now abandoned.
A pharmaceutical combination of Metronidazole and Amoxicillin for the treatment of periodontitis. Conventional therapeutic doses of both the Metronidazole and Amoxicillin given as a combination therapy has been unexpectedly found to effectively treat periodontitis.
A condom assembly adapted to be received by a passive sexual organ includes a condom and a biocompatible, water soluble, shape-retaining insertion element adapted to deliver the condom to a passive sexual organ, such as the vaginal cavity, prior to intercourse and without first affixing the condom to an erect penis. The assembly may include an applicator to further facilitate insertion of the insertion element housing a condom into the passive sexual organ.
A wiper having a controlled release anti-microbial agent therein for providing anti-microbial cleansing of surfaces is provided. The wiper is formed from an absorbent base web to which an anti-microbial formulation is adhered. The formulation includes an anti-microbial agent that is capable of being controllably released from the wiper. In some embodiments, a polymer mixture may be employed to control the rate of release of the anti-microbial agent. Various anti-microbial agents, such as metal ions and organic compounds may be employed.
A use-dependent indicator system for detecting the exhaustion of an active chemical within an absorbent article is provided. The indicator system includes at least one dye component and a polymer mixture. The dye component(s) can be non-reactive and/or reactive dyes. The polymer mixture can contain a polymer, such as a latex adhesive, to facilitate control over the dissolution rate of the dye component(s). By controlling the dissolution rate of the dye component(s), an indicator system of the present invention can impart a change in color to signal the exhaustion of an active chemical incorporated within the absorbent article, such as an anti-microbial agent.
A wiper that provides a controlled release anti-microbial agent has a substrate layer to which the anti-microbial agent is adhered. In addition, the wiper will have one or more laminate layers, at least one of which will be absorbent. Various anti-microbial agents such as silver containing additives, calcium hypochlorite, and chlorine dioxide generating compounds may be employed. The substrate layer may be a poly(ethylene vinyl acetate) meltblown web and the laminate layer may be a hydroentangled composite absorbent fabric.
