This invention relates to 1,1,1,4-substituted naphthaline compounds, compositions, processes for their preparation and processes for their use as pesticides, especially insecticides, acaricides and fungicides.
New compounds of the formula ##STR1## in which R.sub.1 is an allylamino, acetylamino or propionylamino radical, R.sub.2 is hydrogen or a 2-methoxyethoxy or ethoxy radical, R.sub.3 is hydrogen or a sulphamoyl radical, and R.sub.4 is hydrogen, and of the formula ##STR2## in which R.sub.1 is a halogen atom or a free or substituted hydroxyl, sulphhydryl or amino group, R.sub.2 is a hydrogen atom, an alkyl radical, a halogen atom, or a free or substituted hydroxyl, sulphhydryl or amino group, R.sub.3 and R.sub.4 each independently is hydrogen, alkyl, hydroxyl, alkoxy, sulphonamido or halogen, with the proviso that R.sub.2, R.sub.3 and R.sub.4 are hydrogen when R.sub.1 is hydroxyl, exhibit anti-inflammatory activity.
A 2-(1-alkylaminoalkyl)-3-hydroxy-1,4-naphthoquinone of the formula: ##STR1## wherein R.sup.1 is an alkyl group or a cycloalkyl group, and R.sup.2 is an alkyl group having at least 2 carbon atoms. The compounds are used in the preparation of a 2-(1-alkenyl)-3-hydroxy-1,4-naphthoquinone having insecticidal and fungicidal activity and a 2-alkyl-3-acyloxy-1,4-naphthoquinone having insecticidal and fungicidal activity and a 2-alkyl-3-acyloxy-1,4-naphthoquinone having miticidal activity.
A method for the hydrocarbylation of naphthoquinones comprising cross-coupling addition of the hydrocarbyl moiety of selected organometallic reagents to leaving group-substituted naphthoquinones.
1,4-Naphthoquinones of formula (I), methods for their preparation, veterinary formulations thereof, and the use thereof in animal therapy are disclosed. ##STR1## Particularly preferred compounds of formula (I) are, 2-[trans-(4-t-butylcyclohexyl)methyl]-3-hydroxy-1,4-naphthoquinone, and 2-[trans-(4-t-pentyl cyclohexyl)methyl]3-hydroxy-1,4-naphthoquinone. The compounds are of value as anti-protozoal agents, in particular as anti-theilerial agents.
