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Description  |
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention pertains to a bag for storing blood components which is
readily adaptable to a variety of uses. More particularly, this invention
relates to an improved blood component storage bag with a glycerolizing
set which includes inlet and outlet means with specific configurations in
combination with a connector having a configuration adapted to sealingly
mate with the inlet and outlet means.
2. Discussion of the Prior Art
Sterilizable, flexible closed plastic bags of a variety of shapes and forms
have been used as storage containers for blood and various blood
components. In most cases, these bags have been adapted to particular uses
by virtue of specific inlet and outlet configurations in combination with
puncturable diaphragms and integral tubing adapted to the particular use
for which the bag was intended. However, these prior art bags do not
contain any features which would provide a means for preventing the
accidental addition of the wrong additive, medicament or other supplement
which are at times required.
It has been proposed to provide color coded entry ports on the blood
storage bags so that correct reagents can be added and the decants removed
in a proper sequence. However, such color coding would present a problem
in having all personnel which handle the container and the reagents
familiar with the color code, and that such color coding is standardized
throughout the industry. Additional problems in color coding are that
colors tend to fade of otherwise change due to atmosphere or by spillage
of chemical reagents so that the colors may be unreliable.
U.S. Pat. No. 3,963,026 relates to a bag for storing blood components
having features in its construction which may be adapted for use in
connection with the present invention. Additionally, this patent discloses
the utilization of a Y connector which is adapted to communicate with a
glycerin container and with a container of red blood cells.
U.S. Pat. No. 3,951,148 relates to a blood component storage bag and
glycerolizing set containing certain features which may be readily adapted
for utilization in connection with the present invention. One such feature
is the utilization of a connector having a hollow spike which may be
inserted into a container, such as a container of red blood cells, to
permit free fluid passage through the spike into and from the fluid
container.
Therefore, it is a principal object of the present invention to provide a
new and improved bag for storing blood components.
Another object of the present invention is to provide a new and improved
system for either adding to the blood storage bag or removing portions
therefrom in a manner such that the chance of error is substantially
reduced.
SUMMARY OF THE INVENTION
Briefly, the above and further objects of the present invention may be
realized in accordance with the present invention by providing a storage
bag consisting of a sterilizable, flexible closed plastic container with
means for hanging the container either in an upright or inverted position,
the container further including one or more coded inlet-outlet fitments at
the top thereof. Each of the inlet-outlet fitments of the present
invention are of a specially selected configuration, that is, round,
square, hexagonal, etc., which corresponds in shape to a mating connection
of another containers or treatment devices. Preferably, each of the
fitments is provided with a removable cap. The fitments may further be
constructed according to the structure disclosed in U.S. Pat. No.
3,963,026. That is, the fitment may include an outlet comprising a first
hollow outward protrusion with a removable cap and at least one inlet
consisting of a second hollow outward protrusion, the second protrusion
having on its outer diameter a circumferential raised portion having a
configuration so that it can be adapted to sealably engage the inner
diameter of a connector from the glycerolizing set.
In one form of the present invention, the bag may be combined with a simple
and convenient glycerolizing set which sealably engages one of the inlet
protrusions of the bag. The mating portion of the glycerolizing set may be
provided with a hollow spike which is utilized to puncture an entrance
into a sealed container. The glycerolizing set may also include a metering
portion which would regulate the flow rate of fluid into the container.
In the use of the glycerolizing set or any other blood treatment or storage
system with the bag of this invention through a flexible resilient tube
having an end portion mating with the one or more coded protrusions on the
fitment of the bag, a clamp may be provided to ensure the sealing
engagement of the end portion of the tube with the inlet or outlet fitment
protrusions.
In some glycerolizing sets, at least two flexible resilient tubes are each
provided with an external means thereof for restricting fluid flow
therein. For example, a sliding valve with a narrow channel therein fits
over the tubing with an opening in the valve communicating with the
channel usually surrounds the tube during unrestricted fluid passage
through the tube. When it is desired to restrict the fluid passage, the
valve member is slid over the tube with the narrow constriction forced to
collapse the tube so as to restrict fluid flow therethrough. One such
means is a roller squeeze valve means as disclosed in U.S. Pat. No.
3,951,148.
For a better understanding of this invention, reference is made to the
appended claims and to the following detailed description thereof, taken
in conjunction with the drawing in which:
FIG. 1 is a perspective view of the inlet-outlet shape coded fitment
utilized in connection with the blood storage bag of the present
invention;
FIG. 2 is a perspective view of another series of inlet-outlet fitment for
use in connection with a blood storage bag in accordance with the present
invention;
FIG. 3 is a perspective view of the shape coded fitments shown together
with matching shape coated spikes used in connection with the present
invention;
FIG. 4 is a perspective view of the blood storage bag and associated
glycerolizing set in accordance with the present invention; and
FIGS. 5 and 6 are enlarged views, partially in section, of the outlet
opening and associated individual shape coded overlay in accordance with a
further embodiment of the present invention.
With reference to FIG. 1, there is shown a coded port fitment 7 having a
series of hollow outward protrusions 8a, 8b, 8c, 8d and 8e, having
respectively configured lip portions 9a, 9b, 9c, 9d and 9e. The fitment 7
is of such construction so as to be readily adapted for any standard blood
storage bag. Preferably, the fitment 7 has a film portion 10 of heat
sealable material which would permit an economical adaptation of existing
storage bags for use with the coded filament portion.
FIG. 2 shows the coded inlet protrusions in combination with mating coded
styli 10a, 10b, 10c, 10d, and 10e each with a lip portion 11a, 11b, 11c,
11d and 11e, which closely fits the respectively configured lip portions
9a, 9b, 9c, 9d and 9e. Each of the styli 10a, 10b, 10c, 10d and 10e, may
contain conforming hollow spikes 12a, 12b, 12c, 12d and 12e, which enter
the respective inlet protrusions so as to puncture the film 10 and provide
access into the blood storage bag.
FIG. 3 illustrates a further embodiment of the present invention wherein
the only coded portion of the protrusions 8a, 8b, 8c, 8d and 8e are the
lip portions 9a, 9b, 9c, 9d and 9e, which would sealingly engage a
matching connector from another source. There is further illustrated that
the entry ports may contain the hollow spikes 13b, 13c for puncturing an
entrance into another container. Also, as illustrated, the spikes 13b, 13c
need not contain the same configuration as the lip portions 9b, 9c
provided the container has a cover portion having the same configuration
as the lip portion.
Turning now to FIG. 4, there is shown a sterilizable, flexible plastic bag
2, with means consisting of hanging holes 4 and 6 for hanging the bag
either in an upright or inverted position. Bag 2 also includes a closure
fitment 7 with the series of hollow outward protrusions 8a, 8b, 8c, 8d, 8e
with their respectively configured lip portions.
As seen in FIG. 4, the tube 20 is connected to a stylus 10c. The tube 20
has mounted thereon a valve member 21 providing a controllable fluid flow
restrictor as may be required in the functioning or use of the apparatus.
The tube 20 further communicates with a drip chamber 22, consisting of a
relatively large diameter transparent collapsible symmetrical member
attached to a hollow puncturing spike 23, in which is incorporated an
integral air vent 25.
A second flexible tube 26 is connected to stylus 10e for entry into
protrusion 8e. The tube 26 has mounted thereon a second valve means 21'.
The tube 26 is further connected to a second matching stylus 10e' with a
puncturing hollow spike 12e'.
In the use of the bag 2 and glycerolizing set according to the present
invention, particularly in the use of the glycerolizing set in conjunction
with the use of the bag 2 as a free storage container for red blood cells,
fluid flow in tube 20 is first restricted by valve means 21 and drip
chamber 22 is partially collapsed, such as by squeezing it. Spike 23 is
then inserted into a resilient closure cap of a container 30 of glycerin
or other suitable red blood cell preservative and the pressure on drip
chamber 22 is relaxed, whereby glycerin is drawn into it at the same time
air is drawn into the glycerin container through the air vent 25 of the
spike 23. Spike 12e' is inserted in the container 32 of red blood cells
and, with valve means 20 and 21' in an open position and with both the
stylus 10c and 10e inserted in their respective entry protrusions of bag
2, the glycerin container is raised or the red blood cell container is
lowered so that the glycerin enters the red blood cell container. It
should be understood that in this particular step the bag 2 is typically
in the inverted position, i.e., hung by hanging hole 6. After about 100
milliliters of glycerin has passed into the red blood cell container,
fluid flow is constricted by means of valve means 21 and 21'. After
permitting the partially glycerolized red blood cells to equillibrate for
five to ten minutes, the glycerin container and the red blood cell
container are raised above the bag 2, valve means 21' is opened and the
contents of the red blood cell storage container are permitted to flow
into bag 2. Valve means 21 is then opened and the remainder of the
glycerin passes into bag 2. The glycerolizing set may then be sealed from
the bag 2 by any conventional means and separated whereupon the treated
red blood cells in bag 2 are ready for free storage.
FIGS. 5 and 6 illustrate a further embodiment of the present invention
wherein the coded portion is a separate unit which is utilized so as to
adapt any bag having a conventional port to the coded system. The
overlying coded member 28 contains the coded configuration 29. The
overlying coded member 28 may be reusable and formed in any manner so as
to be held by the conventional inlet protrusion, such as being of elastic
means, being internally threaded, or the like.
While this invention has been described with respect to specific
embodiments thereof, it should be understood that this invention is not
limited to these embodiments and that the appended claims are intended to
include these and other features and embodiments as may be devised by
those skilled in the art which are nevertheless within the spirit and
scope of this invention.
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