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BACKGROUND OF THE INVENTION
This invention relates generally to the treatment of incontinence. More
particularly, the instant invention is related to artificial sphincter
systems and associated method for returning volitional control of
excretory vessels to the patient.
Sphincter muscles are utilized by the body to close various duct tubes or
orifices. The sphincter muscle encircles or surrounds its associated duct
tube so that contraction of the sphincter will constrict the passageway.
Urethral sphincter muscles, for example, preferably volitionally open and
close the urethra during micturition. Where sphincter muscles or their
associated nerves and fibers become inoperative because of disease or
damage the unfortunate problem of incontinence will result. A plurality of
prior art artificial mechanisms have been developed in an attempt to solve
the problem of incontinence. Most of these devices function by
intermittently occluding the affected vessel.
Artificial sphincter mechanisms for exteriorly controlling incontinence are
shown in U.S. Pat. No's. 2,455,859 and 2,533,924 issued to F. E. Foley on
Dec. 7, 1948 and Dec. 12, 1950, respectively. The latter two references
are directed towards apparatus for controlling incontinence in males by
exteriorly clamping the urethra. As described in the latter two patents,
the exteriorly operable Cunningham clamp represents a now-outdated
approach for controlling incontinence.
Surgically implantable devices for controlling incontinence are shown
generally in U.S. Pat. No. 3,750,194 issued to G. D. Summers on Aug. 7,
1973, U.S. Pat. No. 3,744,063 issued to McWhorter et al on July 10, 1973
and U.S. Pat. No. 3,863,622 issued to R. E. Buuck on Feb. 4, 1975. The
latter patents generally disclose apparatus comprising a circular cuff
member responsive to fluid pressure for intermittently occluding a vessel,
at least one source of fluid pressure interconnected to the cuff, and one
or more interconnected valves, tubes, reservoirs or the like. An
informative article related to the latter art and entilted "Intermittent
Occlusion System" was published in IEEE Transactions on Bio-Medical
Engineering, October 1970, Volume 17, No. 4, page 352. U.S. Pat. No.
3,538,917 issued to R. G. Selker on Nov. 10, 1970, illustrates an
occlusion clip for selectively blocking flow through a vessel which
includes an expandable, pressure-responsive member which proximally
circumscribes the indicated vessel. U.S. Pat. No. 3,853,122 shows a delay
means.
While the aforementioned implantable devices represent a significant
improvement over earlier external clamping techniques, they are not
without certain disadvantages. Prior art implantable sphincters may become
disengaged in repsonse to bladder spasms or other external forces which
tend to force pressurizing fluid out of the vessel-constricting cuff. In a
urethral incontinence system for example, reduced cuff pressure may result
in involuntary passage of urine. Another problem associated with certain
prior art implantable sphincter systems is that the cuff inflation means
utilized therewith may produce excessive pressure conditions which can
lead to tissue damage. For example, where a prior art inflatable sphincter
member has been implanted tissue damage may result unless fluid can be at
least temporarily displaced from the cuff member in response to
vacillating external forces on the urethra. Known prior art sphincters
must be volitionally manipulated each time the affected vessel is to be
either opened or closed
SUMMARY OF THE INVENTION
The incontinence control apparatus disclosed herein is adapted to be
surgically implanted interiorly of an animal body and is capable of being
controlled exteriorly by simply pressing the skin.
In one form of this invention the artificial sphincter apparatus comprises
an inflatable cuff which circumscribes a vessel to be opened and closed
and proximally engages the vessel to constrict same in response to fluid
pressure, a source of fluid which is preferably connected to the cuff
through a one-way check valve, and a fluid pressure regulator in fluid
flow communication with the cuff which maintains substantially constant
fluid pressure within the cuff to minimize tissue damage. The fluid source
preferably comprises a squeezable, elastometric bulb which is adapted to
be placed inneradjacent the skin for external manipulation thereof.
Pressure regulation is provided by a variable volume chamber which expands
and contracts in response to varying fluid pressure within the cuff. The
variable volume chamber preferably comprises a deformable balloon which
absorbs that volume of fluid in excess of the volume of fluid outputted by
the source required to maintain a predetermined fluid pressure within the
cuff. Since the pressure regulator balloon prevents overinflation of the
cuff member harmful overconstruction of the affected vessel is obviated.
Likewise, when cuff fluid pressure might otheriwse tend to go low, the
regulator maintains continence by preserving the desired cuff fluid
pressure. A releasable valve integral with the fluid source may be
depressed to deflate the cuff when the vessel is to be opened.
In an alternate embodiment of this invention the sphincter apparatus
comprises a low pressure fluid reservoir which is interconnected with a
deformable squeeze pump. Manipulation of the pump delivers fluid from the
reservoir into a cuff (which is similar to that previously described) and
an associated pressure regulator for controllably occluding an affected
vessel. Cooperating valve means are provided within the pump to properly
direct fluid flow. The pump also includes a manually depressible release
valve for volitionally opening the affected vessel by transferring fluid
from the cuff (and the associated pressure regulator) back into the fluid
reservoir. The fluid pressure regulator is preferabl located interiorly of
the reservoir to effectively isolate the regulator from contact with the
body fluids.
In an alternative embodiment the vesicular occluding cuff and its
associated variable volume pressure regulator are interconnected via a
unique squeezable pump bulb. Manipulation of the latter pump bulb
transfers fluid from the cuff into the variable volume device, thereby
deflating the cuff and opening the vessel so that body fluids may pass
therethrough. The pump bulb is provided with check valve means for
properly directing the fluid in response to rapid squeezing. Importantly,
however, a flow bypass path is included to facilitate gradual, automatic
transfer of fluid from the variable volume chamber into the cuff to slowly
occlude the affected vessel. The latter path is preferably provided
through a constricted passageway within the pump bulb. Thus the cuff fills
automatically in response to fluid pressure provided by the variable
volume chamber, and manipulation of a separate valve is obviated.
One method of treating incontinence described herein is initiated by
surgically implanting an inflatable cuff in circumscribing, proximal
engagement with the vessel to be opened and closed. A preferably
squeezable source of fluid interconnected with the cuff is located at a
location within the animal body inneradjacent the skin so that it may be
squeezably manipulated from outside the body to fill the cuff.
Importantly, a fluid pressure regulator is located at still another
location within the animal body and placed in fluid flow communication
with the cuff member. The pressure regulator preferably comprises a
physiologically inert, distensible balloon member which will expand and
contract in response to cuff fluid pressure. In a preferred form of this
method, a one-way check valve is housed within the fluid source and
interconnected between the fluid source and the expansible cuff to
facilitate filling of the cuff. The source must be positioned such that a
release member associated with the valve may be externally manipulated
through the skin to open the affected vessel by deflating the cuff (and
the pressure regulator). A similar method disclosed here preferably
employs a fluid reservoir having the pressure regulator disposed therein
and a squeezable pump for transferring fluid between the cuff (and
associated pressure regulator) and reservoir.
Another method disclosed herein involves surgical implantation of an
inflatable cuff, a variable-volume fluid reservoir, and a squeezable pump
for transferring fluid therebetween. With the latter method the cuff is
deflated by squeezing the pump, and displaced fluid is stored within the
expansible chamber. Importantly, a restricted passageway extending between
the chamber and the cuff facilitates gradual passage of fluid from the
chamber into the cuff to automatically inflate same to occlude the
affected vessel. The latter method preferably includes the step of
locating the restricted passageway within the squeezable pump.
Thus, an important object of this invention is to provide artificial
sphincter apparatus which will minimize the possibility of tissue damage.
The important fluid pressure regulation feature of this invention obviates
unwanted pressure excesses which might otherwise occur.
Another object of this invention is to provide implantable sphincter
apparatus which may be exteriorly operated by the patient through the
skin. It is a feature of this invention that the fluid pump utilized
thereby is adapted to be located inneradjacent the skin for external
manipulation.
Still another object of this invention is to provide sphincter apparatus of
the character described which will closely approximate the functioning of
natural micturition.
Yet another object of this invention is to provide sphincter apparatus
which will enable predetermined physical activities by the patient. An
important result of the fluid pressure regulator apparatus incorporated in
the instant invention is that overconstriction of the affected vessel is
obviated. Thus, bending and stressed forces incurred by the affected
vessel during exercise periods will therefore not cause pressure buildup
within the cuff and the resultant tissue damage associated therewith.
Alternatively, decreases in cuff pressure caused by bending or twisting
forces will be remedied by the fluid pressure regulating means to prevent
embarrassng or unwanted fluid passage through the affected vessel.
Still another object of this invention is to provide sphincter apparatus of
the character described which will not be affected by bladder spasms or
external forces experienced by the cuff. The latter characteristics make
the instant apparatus ideally suited for treatment of urinary
incontinence.
Another object of this invention is to provide sphincter apparatus of the
character described which will predictably maintain cuff pressure within
predetermined, known limits.
Yet another important object of this invention is to provide artificial
sphincter apparatus which requires only minimal patient manipulation for
operation. One important form of this invention is characterized by
automatic cuff inflation.
A still further object is to provide a pump bulb for use with artificial
sphincter systems which facilitates automatic inflation of a desired
element of the apparatus.
A further object of this invention is to provide methods for treating
incontinence. Importantly, the methods disclosed herein are characterized
by automatic maintenance of predetermined cuff pressure.
These and other objects of this invention, together with features of
novelty appurtenant thereto, will appear or become apparent in the course
of the following detailed description.
BRIEF DESCRIPTION OF THE DRAWINGS
In the following drawings, which form a part of the specification and are
to be construed in conjunction therewith, and in which like reference
numerals have been employed to indicate like parts in the various views:
FIG. 1 is a pictorial view of a pressure-regulated artificial sphincter
system constructed in accordance with the teachings of this invention with
parts thereof broken away or shown in section for clarity;
FIG. 2 graphically depicts the general relationship between the volume of
fluid inputted to the pressure regulator and the corresponding fluid
pressure therewithin;
FIG. 3 is a pictorialview of a pressure-regulated artificial sphincter
system including a low pressure reservoir, with parts thereof broken away
or shown in section for clarity;
FIG. 4 is a sectional view of the pump bulb valve structure taken along
line 4--4 of FIG. 3 showing the sealed upper chamber therein;
FIG. 5 is a pictorial view of a pressure-regulated artificial sphincter
system characterized by automatic cuff inflation, and with parts thereof
broken away or shown in section for clarity;
FIG. 6 is an abbreviated sectional view of a human torso showing the
preferred location of the sphincter system shown in FIG. 1; and,
FIG. 7 is a perspective view illustrating a cuff member in proper position
on an affected vessel which is to be artifically opened and closed.
DETAILED DESCRIPTION OF THE DRAWINGS
Referring initially to FIG. 1, a pressure-regulated artificial sphincter
system 10 comprises a generally circular cuff member 12 which encircles an
affected vessel 14, a variable volume chamber 16 which regulates system
fluid pressure, and a preferably manually actuable pump 18 which contains
a physiologically inert fluid 19. Cuff 12 receives fluid 19 from pump 18
through a pair of physiologically inert, tubular plastic hoses 20 and 21.
Similarly, pressure regulator 16 receives fluid through hoses 20 and 22.
The system 10 is activated by squeezing pump 18 thereby forcing fluid into
cuff 12 and regulator 16.
Cuff 12 includes a deformable membrane or wall portion 24 which proximally
circumscribes vessel 14. As cuff fluid input pressure increases membrane
24 will expand and thereby occlude vessel 14. The cuff will be discussed
in more detail later in conjunction with FIG. 7. The cuff is shown and
described in U.S. Pat. No. 3,863,622 issued to R. E. Buuck on Feb. 4,
1975, which is hereby incorporated by reference. Importantly, the cuff
members employed in each of the embodiments shown in FIGS. 1, 3 and 5 are
identical.
The variable volume chamber 16 preferably comprises a distensible balloon
member 26. Balloon 26 is preferably comprised of physiologically inert
elastomer. The balloons employed by the embodiments of FIGS. 1, 3 and 5
are identical.
As fluid enters balloon 26 and cuff 12 vessel 14 will become constricted in
response to expansion of member 24. Pressure will gradually rise until a
predetermined pressure p.sub.b (FIG. 2) is reached. At this time balloon
26 will expand and substantially maintain the pressure within member 24
(and tubes 20, 21 and 22) equal to pressure p.sub.b. Balloon 26 thus
displaces a volume of fluid in excess of the amount necessary to maintain
pressure p.sub.b in the cuff 12, and in so doing it will eventually occupy
the larger diameter volume indicated by dotted lines (FIG. 1). A portion
30 of the graphical pressure-volume trace shown in FIG. 2 represents the
pressure regulator characteristics of the balloon. The relatively small
slope of this segment indicates that fluid pressure within the balloon
(and the cuff) is substantially constant. As will be described in more
detail later, fluid backflow into the pump 18 is prevented at this time.
Initial filling of balloon 26 is generally indicated by graphical segment
32 (FIG. 2).
The fluid source 18 preferably comprises a deformable elastometric bulb 34
which sealably encloses fluid 19 and a releasable check valve assembly 36.
Check valve 36 preferably comprises a rigid, plastic cube 38 in which a
plurality of passageways have been provided. A first passageway 39
receives hose 20. A second passageway 40 is in communication with fluid 19
interiorly of the bulb. A generally cylindrical, transverse passageway 42
extends between passageways 39 and 40 to interconnected same. Passageway
42 contains a funnel shaped, tapered poppet plug 44, a similarly tapered,
resilient toroidal valve seat 46, and a coiled spring 48 which normally
biases plug 44 towards to block passageway 42. When bulb 34 is squeezed,
the resulting increased fluid pressure at orifice 40 will be sufficient to
deflect plug 44 leftwardly (as viewed in FIG. 1) thereby exposing an
orifice in seat 46 and thereby opening the valve. When the squeeze bulb is
released spring 48 will urge plug 44 into engagement with seat 46 to
prevent fluid backflow by blocking passageway 42. The bulb can thus be
released after filling cuff 12 without fear of inadvertent cuff deflation.
Valve assembly 36 is adapted to be manually released to deflate cuff 12 and
thereby open the affected vessel 14. Plug 44 includes an elongated,
cylindrical release stem 49 which extends through the orifice within seat
46 and exits from cube 38. A tip portion 50 of release 49 may be contacted
by depressing bulb side wall portion 51, such that plug 44 is moved toward
the left (as viewed in FIG. 1) against predetermined tension from spring
48. When fluid is thereby transferred back into bulb 34 the vessel 14 will
become unblocked.
As various vibrations or shock forces are experienced by vessel 14
deformable cuff portion 24 will experience slight deformation. However,
the buildup of fluid pressure within the cuff in response to deformation
thereof will be prevented by deformable balloon 26. Balloon 26 will
maintain substantially constant fluid pressure by absorbing that volume of
fluid in excess of the amount of fluid necessary to maintain a
predetermined cuff pressure. The instant apparatus will thus constrict the
affected vessel to maintain continence while obviating harmfull cuff
pressure excesses. The pressure regulating affect of the balloon will also
prevent sudden pressure drops within the cuff which might occur, for
example, during moderate physical activities. Thus inadvertent or
embarrassing excretion through the vessel 14 will be obviated.
A slightly modified artificial sphincter system 54 is shown in FIG. 3.
System 54 preferably comprises a toroidal cuff member 12a, a distensible
balloon member 26a for regulating fluid pressure, a low pressure fluid
reservoir 56, and a squeezable pump bulb 58 for distributing fluid from
reservoir 56 to balloon 26a and cuff member 12a. Cuff 12a is identical to
cuff 12, and it comprises an expansible wall portion 24a which proximally
surrounds a vessel 14a which is to be opened and closed. Balloon 26a is
identical to balloon 26. Unlike pump bulb 34, however, pump bulb 58 is
adapted to be squeezed several times to transfer fluid throughout the
system 54. For the latter purpose a valve assembly 60 (FIGS. 3 and 4) is
included within the upper confines of the bulb 58.
Reservoir 56 preferably comprises a physiologically inert, deformable
volume which surrounds and encloses balloon 26a. Reservoir 56 is in fluid
flow communication with bulb 58 through a tubular hose 61, which is
sealably received within valve assembly 60. It is apparent that in the
event of failure or rupture of balloon 26a its contents will be confined
within the reservoir 56. Alternatively bulb 26a can be located externally
of the reservoir.
Valve assembly 60 is adapted to direct fluid from reservoir 56 to the cuff
and balloon regulator in response to multiple squeezing of bulb 58. Valve
assembly 60 also facilitates manual transference of fluid out of cuff 12a
(and regulator 26a) and back into reservoir 56. Assembly 60 comprises a
generally cubical frame block 62 in which a plurality of passageways have
been formed by drilling or the like. Block 62 is preferably adhesively
secured to the upper wall portions interiorly of the bulb 58.
Passageway 64 contains a funnel-shaped poppet plug 65, a similarly tapered
toroidal valve seat 66, and a spring 67 which biases the plug 65 into
engagement with seat 66 to normally block passageway 64. A passageway 68
which communicates with reservoir 56 via hose 61 contains another check
valve comprised of a spherical plug 70, a smaller diameter tapered valve
seat 72, and a retainer orifice 74 which maintains plug 70 within
passsageway 68. Each time bulb 58 is squeezed, plug 65 will become
dislodged and fluid will be outputted through passageway 64 into hose 20a,
thereby filling cuff 12a and regulator 26a. Each time bulb 58 is
subsesquently released, passageway 64 will become blocked, passageway 68
will open, and fluid within reservoir 56 will be sucked into the bulb. the
increasng fluid output pressure will occlude vessel 14a by expanding cuff
portion 24a in the manner previously described. Cuff fluid pressure will
be limited to a pressure p.sub.b (FIG. 1) by regulator 26a.
When it is desired to open vessel 14a, cuff 12a (and balloon regulator 26a)
are deflated by draining fluid therein back into reservoir 56. A separate
passageway 76 (FIG. 4) is provided to manually transfer fluid from
passageway 64 into passageway 68. Passageway 76 communicates with
passageway 64 through an orifice 77, and with passageway 68 through an
orifice 78. Passageway 76 includes a funnel shaped poppet plug 79, a
similarly tapered toroidal valve seat 80, and a preferably coiled spring
81 which normally biases plug 79 into releasable engagement with seat 80
to selectively block passageway 76. The upper plug end 79a interiorly
abuts bulb wall portion 82 so that plug 79 may be manually depressed by
squeezing the bulb near the upper portion thereof. When plug 79 is
depressed, fluid pressure within regulator 26a and cuff 12a will force
fluid back into reservoir 56 through hose 61. Afterwards the cycle may be
repeated by again squeezing bulb 58 to reinflate the cuff (and balloon
regulator 26a) in the manner previously described.
The artificial sphincter apparatus 84 (FIG. 5) also includes a variable
volume balloon regulator 26b and a cuff 12b for occluding a circumscribed
vessel 14b. A preferably squeezeable, elastomatic pump bulb 86 directs
fluid 19 between regulator 26b and cuff 12b. Unlike the previously
described embodiments however, apparatus 84 is adapted to automatically
inflate associated cuff member 12b after a predetermined time. In response
to squeezing bulb 86 will deflate cuff 12b to thereby temporarily open the
affected vessel 14b.
The preferably elastic bulb wall 88 encloses a fluid containing space 89
and a valve assembly 90, which is adhesively secured within the upper
confines of bulb 86. Bulb 86 includes a first fluid passageway 92 which
communicates with cuff 12b through a hose 94, and a second fluid
passageway 96 which communicates with regulator 26b through a similar
tubular hose 98.
Pump bulb 86 is adapted to transfer fluid from cuff 12b into balloon means
26b in response to squeezing thereof. Thus, unlike the previously
described embodiments, squeezing of bulb 86 will open the affected vessel
14b. Valve assembly 90 facilitates fluid transfer by properly directing
fluid. Assembly 90 includes a cubical frame 100 in which a plurality of
passageways are defined by drilling or the like. A first valve passageway
92a (in fluid flow communication with passageway 92) is intermittently
closed by a check valve comprised of spherical plug 102, tapered valve
seat 103, and plug retaining insert 104. One-way fluid transfer from
passageway 92 into space 89 is thereby facilitated in response to bulb
suction. A similar valve passageway 96a (which communicates with
passageway 96) has a one-way check valve comprised of a retainer insert
106, a spherical plug 107, and a toroidal valve seat 108. Seat 108 has an
upper, tapered shoulder portion 109 and a central orifice 110 which
communicates with space 89./ Thus one-way transfer of fluid from space 89
through passageways 110, 96a and 96 occurs in response to squeezing of the
bulb 86. In this manner fluid is transferred from the cuff 12b into the
distensible balloon regulator 26b, which expands in response thereto while
maintaing substantially constant pressure (FIG. 2).
Importantly, a flow bypass resistance passageway 112 interconnects
passageways 96a and 96 with passageways 92a and 92. Fluid flow through
passageway 112, however, is impeded by a restriction 114, which preferably
comprises glass filter material having a diameter substantially the same
as passageway 112. In response to the predetermined pressure within
regulator 26b, fluid will gradually be transferred through restricted
passageway 112 and into cuff 12b to inflate portion 24b thereof. Thus
vessel 14b will gradually be occluded by the delayed passage of fluid
enabled by the flow resistive passageway 112. The cuff portion 24b is thus
automatically inflated after a predetermined time to occlude passageway
14b without additional manipulation by the patient. As in the case of the
previously discussed embodiments, the balloon regulator means will
substantially maintain an equilibrium pressure of p.sub.b (FIG. 2).
Each of the previously described artificial sphincter embodiments is
adapted to be surgically implanted completely within an animal body. In
FIG. 6 the sphincter apparatus 10 has been installed within a human torso
to remedy urinary incontinence by providing a substitute for a defective
urethral sphincter muscle. Cuff 12 circumscribes urethra 116 which extends
from the bladder 117. The balloon regulator 26 is located within the
peritoneal cavity 118, and squeeze pump 34 is preferably located within
the scrotum (or labia in the case of a female).
In each case the sphincter apparatus is implanted within the trunk 122 by
first makingg an abdominal incision through the skin 124 overlying the
pelvic cavity 125. After the urethra 116 is exposed, the cuff member is
implanted around it by a prior art wrapping procedure in which the cuff
ends are tied together. As best shown in FIG. 7, the cuff 12c is folded
around a vessel 126 and preferably fastened thereto by tying cuff ends 128
and 129 together with a plurality of sutures 130. The fluid supply tube
132 is then carefully routed toward the desired fluid source. The latter
procedure is discussed generally in U.S. Pat. No. 3,863,622 which is
hereby incorporated by reference.
In each case the pump bulb is located so that it may be externally
manipulated by pressing it through the skin. In the case of systems 10 and
54 the squeeze bulb must be positioned such that valve portions 50 and
79a, respectively, may also be actuated through the skin.
It should be apparent that the instant invention is of equal utility in
treating males or females. Because fluid flow is limited to a closed
system operative reliability is enhanced. Fluid pressure maintenance
provided by the balloon regulator in part obviates the need for a
plurality of check valves otherwise employed by some prior art devices.
Notwithstanding the operative reliability of the apparatus, it is
preferable to include a radio-opaque dye within the physiologically inert
liquid 19 is utilized by the apparatus. In the rare event that problems
later develop the dye enables investigation with conventional X ray
techniques.
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