Bifunctional immunoadsorbents containing complementary antigens and antibodies which are useful for detecting the presence of complementary antigens and antibodies in serum are described.
A mediator substance exhibiting inhibitory effect upon anabolic enzyme activity in mammals, is prepared by a method comprising gathering a sample of macrophage cells from a mammal, incubating a portion of the macrophage cells with a stimulating material that is associated with an invasive event, and inducing the macrophage cells to produce the mediator substance. The stimulator materials, for example, may include endotoxins, trypanosomes and the like, and the enzymes that may be observed range from lipoprotein lipase, acetyl Coenzyme A carboxylase and fatty acid synthetase, to the inducers for red blood cells growth and differentiation. The mediator substance may be utilized to raise antibodies which would in turn find utility in testing for the presence or amount of various invasive stimuli, such as infection and the like. Testing procedures and appropriate materials in kit form are also contemplated. The mediator substance may likewise be utilized in procedures as a screening agent, to test for potentially effective anti-shock agents or chemicals.
4604348 - Composition for use in immunoassays - Owned by New York Blood Center, Inc. (New York, NY) [*] Notice:The portion of the term of this patent subsequent to July 10, 2001 has been disclaimed.
A composition having a protein binding solid support onto which is bound a mixture of antigens and antibodies which are both bound to the solid support individually and are not present in the form of an immune complex.
Provided are therapeutic uses of antibodies capable of neutralizing the adverse effects in humans of the about 70 kDa mediator produced upon invasive stimulation of macrophages by, e.g., contact with endotoxin.
Pharmaceutical compositions are provided which comprise neutralizing antibodies to the about 70 kDa mediator produced upon invasive stimulation of macrophages by, e.g., contact with endotoxin.
Catalysts consisting of A) an alcoholate of the rare earths, a carboxylate of the rare earths, a complex compound of the rare earths with diketones and/or an addition compound of the halides of the rare earths with an oxygen or nitrogen donor compound, B) an aluminium trialkyl, a dialkyl aluminium hydride and/or an alumoxane, C) another Lewis acid and D) an inert, particulate inorganic solid with a specific surface of greater than 10 m.sup.2 /g (BET) and a pore volume of 0.3 to 15 ml/g are eminently suitable for the polymerization of conjugated dienes, more particularly butadiene, in the gas phase.
