A .sup.99m Tc-labeled radioactive diagnostic agent, prepared by contacting .sup.99m Tc in the form of a pertechnetate with a non-radioactive carrier comprising pyridoxal or salt thereof, a stannous salt and an .alpha.-amino acid not having any hydrophilic functional group dissolved in an aqueous medium. This diagnostic agent is suitable for the examination of hepatobiliary ducts due to its smooth transfer through the hepatobiliary ducts as well as its high stability and non-toxicity.
A .sup.99m Tc-labeled radioactive diagnostic agent being useful for visualization and dynamic inspection of hepatobiliary ducts and having a high stability and no material toxicity, which comprises .sup.99m Tc in the form of pertechnetate and a non-radioactive carrier, the non-radioactive carrier comprising an N-pyridoxyl-.alpha.-amino acid of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are each an atom or an atomic group present in the .alpha.-amino acid residue encompassed by the dotted line and R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are each a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.10 alkyl group or a C.sub.1 -C.sub.10 alkyl group substituted with at least one hydrophilic group or its salt, and a reducing agent for pertechnetate.
Described is a process for preparing extruded functional fluid and solid-containing thermoplastic foamed particles using chemical blowing agents or direct gas extrusion processes, uses of such foamed particles and articles produced from said foamed particles. The process described involves the use of a single screw or double screw extruder wherein the resin particles are added upstream from the functional fluid or solid which, in turn, is added to the extruder upstream from the point of addition of the liquid or gaseous blowing agent.
A method of imaging organs with .sup.99m Tc radiopharmaceuticals, especially of hepatobiliary imaging and negative myocardial infarct imaging in a mammal which comprises administering to the mammal a hepatobiliary or myocardial imaging amount of a cationic lipophilic complex of Tc-99m and detecting the Tc-99m complex in the mammal. A method for the preparation of cationic lipophilic complexes of Tc-99m.
This invention relates to bifunctional coupling agents useful in forming conjugates with biologically useful molecules, such as antibodies. These conjugates can be complexed with radionuclide metal ions to provide materials useful for in vivo diagnostic and therapeutic applications.
A method of imaging organs with .sup.99m Tc radiopharmaceuticals, especially of hepatobiliary imaging and negative myocardial infarct imaging in a mammal which comprises administering to the mammal a hepatobiliary or myocardial imaging amount of a cationic lipophilic complex of Tc-99m and detecting the Tc-99m complex in the mammal. A method for the preparation of cationic lipophilic complexes of Tc-99m.
