An improved method is provided for the prevention of schistosomiasis in her animals. The topical application of a composition containing a dehydroabietylamine or a derivative thereof provides a coating of perdurable anti-penetrant through which the infective cercariae of the parasitic worm do not pass readily.
In various aspects, the invention provides compounds that bind to one or more RANTES receptors for the treatment of chemokine mediated disease states, such as compounds of formula (I): ##STR1##
Disclosed is a process for the preparation of stilbene compounds such as bis(2-benzoxazolyl) stilbenes by reacting a stilbenedicarboxylate such as dimethyl-4,4'-stilbenedicarboxylate with an o-aminophenol in an organic solvent such as chloronaphthalene in the presence of a catalytic amount of a tin or titanium compound. The reaction is typically carried out at a temperature of about 200.degree.-250.degree. C. and a preferred catalyst is either dibutyl tin oxide or titanium tetra-alkoxide.
