Aspirin-isopropylantipyrine (N-3'a-propylphenazonyl-2-acetoxybenzamide) of the following formula ##STR1## and its pharmaceutical use. This compound can be prepared by reacting 1-phenyl-2-methyl-3-aminomethyl-4-isopropylpyrazolone of the formula ##STR2## with a member selected from the group consisting of acetylsalicylic acid and a reactive acid derivative thereof, and is useful as an analgetic, antipyretic and anti-inflammatory agent.
This invention provides an antipyretic analgesic preparation having good antipyretic and analgesic effects with reduced adverse effects such as gastrointestinal disorders. The object is achieved by providing a mixture composition containing ibuprofen and isopropylantipyrine. The ratio between them is preferably 5:1 to 1:5, more preferably 3:1 to 1:3, on the weight basis. Preferred dosage forms of the mixture composition are a three-layer tablet comprising an ibuprofen-containing first layer, an isopropylantipyrine-containing third layer, and a second layer composed of one or more inactive ingredients alone as provided between said first and third layers, a dry coated tablet internally having an ibuprofen- or isopropylantipyrine-containing core tablet, and so forth.
1-(3-Halo-2-pyridinyl)piperazine and its acid addition salts are selective .alpha..sub.2 -adrenergic receptor antagonists and thereby useful as antidepressant agents and for treating sedation caused by antihypertensive therapy.
