A process for the preparation of polyvinylpyrrolidone-iodine, wherein a polyvinylpyrrolidone which has been subjected to hydrogenation is reacted with iodine in a conventional manner. The novel process is particularly suitable for use with low molecular weight polyvinylpyrrolidone, having a K value of from 10 to 20.
A novel, highly water soluble complex of a substantially insoluble organic compound and a solid homopolymer or copolymer of N-vinyl-2-pyrrolidone. The complex exhibits water solubilities in excess of about 25-fold that of the insoluble organic compound. A method for producing the complex is disclosed wherein the polymer and insoluble compound are dissolved in a mutual solvent, allowed to react for a period of time sufficient to form the complex, and then the solvent is removed to produce the dried highly water-soluble complex.
A method for increasing the water-solubility of highly insoluble organic compounds by forming a complex product from the reaction between the organic compound and an aqueous solution of solid polyvinylpyrrolidone. The solubility of the organic compound can be increased at least 25-fold and the complex formed is highly stable at ambient conditions.
What is described herein is a PVP-I.sub.2 composition comprising strongly swellable, lightly crosslinked PVP complex to iodine, wherein said composition is capable of releasing free iodine slowly with time in the presence of water. Preferably the complex has about 10-15% by weight available iodine and about 4-8 weight % iodide, and is a free-flowing, fine, lightly yellow powder.
A method for increasing the water-solubility of highly insoluble organic compounds by forming a complex product from the reaction between the organic compound and an aqueous solution of solid polyvinylpyrrolidone. The solubility of the organic compound can be increased at least 25-fold and the complex formed is highly stable at ambient conditions.
