A method of using carboxyfluorescein in ophthalmic studies comprising applying of the eye an effective amount of at least one active isomer of carboxyfluorescein.
A process and composition for ophthamological testing for patency in which there is direct observation of the rate and direction of flow of the composition toward and into the punctal orifices. The composition is a suspension of highly visible, minute particles in an isotonic liquid carrier, a drop of which is applied to the eyeball and the movement of the discrete particles observed under magnification at the meniscus formed at the margin of the eyelids.
A method of performing angiography of the occular fundus of an eye of a patient includes the steps of injecting intravenously calcein into the patient in an effective amount immediately prior to angiography and performing angiography on the patient. The invention further discloses a method of performing photocoagulation therapy and/or photodynamic therapy and angiography of the ocular fundus of an eye of a patient which includes the steps of performing photocoagulation therapy, injecting intravenously calcein into the patient in an effective amount immediately prior to angiography, and performing angiography on the patient.
A method for performing retinal membrane removal is disclosed using vital dyes which are applied to the membrane. Compositions including vital dyes which are useful in the retinal membrane removal methods are also disclosed.
Methods for performing a capsulorhexis are disclosed wherein a dye is used to stain a lens capsule of an eye. The dye is capable of staining tissue without diffusing through the tissue. Compositions including dyes that are useful in the methods are also disclosed.
A liposome composition with enhanced retention on ocular surfaces, for use in ophthalmic drug delivery and dry eye treatment. The liposomes contain about 10-40 mole percent of an amine-derivatized lipid component in which a charged amine group is spaced from a lipid polar head region by a carbon-containing spacer arm at least 3 atoms in length. The liposomes preferably have a close packed lipid structure produced by inclusion of between 20-50 mole percent of cholesterol or an amine-derivatized cholesterol, and/or phospholipids with predominantly saturated acyl chain moieties. The liposomes may be suspended in an aqueous medium containing a high-viscosity polymer, formulated in paste form, or embedded in a polymer matrix, to enhance further the retention of liposomes on a corneal surface.
