A package comprising a cylindrical plastic tube closed at each end by an ultrasonic band seal. The seal at one end has a sealed region which is narrower than any portion of the other seal whereby squeezing of the package produces an immediate one-shot dispensing of liquid contained therein by causing rupture of the narrow region of the seal. Various package forms include perpendicularly arranged bands to provide a tetrahedral shape, a tab extending beyond one seal to provide identification of the contents of the package, notched seals providing a tear open package, and a multiple package construction in which one fluid containing tube is contained within another.
A method of treatment of breast cancer in susceptible animals whose ovarian hormonal secretions are blocked by surgical or chemical means, e.g., by use of an LH-RH agonist, e.g., [D-Trp.sup.6, des-Gly-NH.sub.2.sup.10 ]LH-RH ethylamide with a therapy comprising administering an antiandrogen, e.g., flutamide and an optionally, an inhibitor of adrenal sex steroid biosynthesis e.g., aminoglutethimide, pharmaceutical compositions useful for such treatment and two, four and five component pharmaceutical kits containing such compositions are disclosed.
The present dual chamber sachet overcomes the problem of non-uniform dispensing when the sidewalls of the sachet are depressed. Through the use of a relatively thin intermediate divider wall, rounded corner edges at the lower end of each chamber of the sachet, tapered side edges up to the exit channel of each chamber of the sachet, and a relatively wide dispensing opening uniform dispensing can be achieved. This structure prevents the downward flow of substances in each chamber during dispensing. The substances are directed upwardly by the rounded lower corners of the sachet, the tapered upper walls and the wide dispensing opening. This relatively wide dispensing opening minimizes the back pressure caused by the substances flowing to a dispensing exit of a width less than that of the product chambers.
A toothpaste dispenser capable of dispensing individual quantity controlled amounts of toothpaste in a sanitary manner without the possibility of cross contamination. The dispenser includes an elongated strip having a plurality of one time use sachets formed integrally therewith, each sachet containing a measured quantity of toothpaste therein suitable for a single use. The strip is provided with weakened portions so that individually numbered sachets may detached from the strip. The individual sachets may be opened after they are detached from the strip and the contents may be squeezed out. In addition, the sachets may be color coded which is useful when the usage of more than one child is being monitored. A parent may monitor the usage of the individual sachets by reviewing the number, and if more than one child is in the family, the color of the emptied sachet.
A device that includes at least two chambers separated by an activatable seal wherein upon activation of the seal the two chambers are in communication, and further wherein at least one chamber of the device includes a biological assay reagent and methods of using same.
A device that includes at least two chambers separated by an activatable seal wherein upon activation of the seal the two chambers are in communication, and further wherein at least one chamber of the device includes a biological assay reagent and methods of using same.
