Aqueous parenteral solutions of from about 10 to 20% w/v of sulfamethoxazole or sulfadoxine and about 3 to 5% w/v of trimethoprim in from about 60 to 80% w/v of 2-pyrrolidone are disclosed.
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a division of application Ser. No. 170,490, filed on July 21, 1980 which in turn is a continuation of application Ser. No. 54,546, filed on July 5, 1979 and now abandoned.
A stable aqueous formulation containing as active substance an active-substance combination consisting of 2,6-diamino-5-(3',4', 5'-trimethoxybenzyl)-pyrimidine (trimethoprim) and either sulfachloropyrazine of the formula ##STR1## or a salt thereof, or sulfachloropyridazine of the formula ##STR2## or a salt thereof, for combating bacterial and protozoal diseases in animals by means of drinking water application. Besides the stated active substances, the formulation contains an organic solvent, a solubilizer, a surfactant and water.
The absorption of orally administered substantially aqueous insoluble psychoactive 2-aryl-pyrazolo [4,3-C] quinolin-3-ones of the formula ##STR1## where R" is hydrogen, lower alkyl, lower alkoxy, hydroxy, halo or trifluoromethyl, and R' is hydrogen, lower alkyl, lower alkoxy, hydroxy, halo, trifluoromethyl, nitro, amino, mono- or di-lower alkylamino, mono- or di-lower alkylcarbamoylamino, mono- or di-lower alkylcarbamoyloxy or cyano, or a pharmaceutically acceptable salt thereof, is enhanced by administering the same in the form of a storage stable solid molecular dispersion of polyvinylpyrrolidone.
