CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a divisional application of Ser. No. 268,502 filed May 29, 1981, now U.S. Pat. No. 4,364,954 which is a divisional application of Ser. No. 111,043 filed Jan. 10, 1980, now U.S. Pat. No. 4,292,321 which is a continuation application of Ser. No. 42,175 filed May 24, 1979, now abandoned.
Invented is a method of preventing or delaying the occurrence of acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus (HIV) seropositive humans which comprises administering to such human an effective therefor amount of a substituted azaspirane.
A monohydrate of an aminobenzenesulfonic acid derivative represented by the following formula (I), for example, 2-(1-piperazinyl)-5-methylbenzenesulfonic acid, is substantially free from weight change due to moisture absorption and can be weighed accurately in manufacturing a pharmaceutical composition for the treatment of heart diseases comprising said monohydrate. ##STR1##
A monohydrate of an aminobenzenesulfonic acid derivative represented by the following formula (I), for example, 2-(1-piperazinyl)-5-methylbenzenesulfonic acid, is substantially free from weight change due to moisture absorption and can be weighed accurately in manufacturing a pharmaceutical composition for the treatment of heart diseases comprising said monohydrate. ##STR1##
