A free flowing granulation, comprising a high concentration of acetaminophen and a low level of excipient, including ground cross-linked sodium carboxymethylcellulose fiber, allows the manufacture of analgesic tablets by direct compression. The method provides improvements in manufacturing economics and tablet properties.
A therapeutic taste-neutral powder form of acetaminophen obtained by spray-drying a dispersion of acetaminophen and ethyl cellulose in water having a plasticizer dissolved or suspended therein.
4767789 - Spray dried acetaminophen - Owned by American Home Products Corporation (Del.) (New York, NY) [*] Notice:The portion of the term of this patent subsequent to July 26, 2005 has been disclaimed.
A therapeutic taste-neutral powder form of acetaminophen obtained by spray-drying a suspension of acetaminophen in a solution of ethylcellulose in an organic solvent selective for ethylcellulose.
The invention involves a granulating composition composed of an aqueous solution of magnesium sulfate heptahydrate and sodium hexametaphosphate. This composition can be used to prepare granules of ingredients for inclusion in any formulation for which rapid disintegration or dispersion are important factors. It is useful for tablets containing ingredients which are difficult to compress and is particularly useful for formulating swallowable tablets of a single non-soluble ingredient such as calcium carbonate. Disintegration times are markedly decreased.
The invention involves a granulating composition composed of an aqueous solution of magnesium sulfate heptahydrate and sodium hexametaphosphate. This composition can be used to prepare granules of ingredients for inclusion in any formulation for which rapid disintegration or dispersion are important factors. It is useful for tablets containing ingredients which are difficult to compress and is particularly useful for formulating swallowable tablets of a single non-soluble ingredient such as calcium carbonate. Disintegration times are markedly decreased.
The present invention relates to a granular product comprised of a solid product which has been provided with a coating of a melt of itself, as well as a process for the preparation of the granular product.
