A new substance having antitumor activity is obtained from an epidermal portion of rice. A substance called RBF-P is obtained by adding ethanol to an aqueous alkaline extract of rice bran, removing the insolubles and precipitating the substance by addition of an acid. This substance comprises an active substance called RBF-PM, which is insoluble in methanol, and an active substance called RBF-X, which is soluble in acetone. The substance RBF-PM is a protein containing extremely little cystine and said protein can suppress solid cancers of mice. The substance RBF-X is a mixture of hexane-solubles such as fatty acids and a hexane-insoluble called RBF-H. A synergistic suppressive action on ascites hepatoma of mice is exhibited by the combination of the RBF-H and the fatty acids.
A protein having a polypeptide subunit containing an N-terminal amino acid sequence of Ser-Ala-Ser-Arg-Ala-Leu-Ser-Asp-Lys-Pro-Leu-Ala-His-Val-Val-Ala-Asn-Pro-Gl n-Val-Glu-Gly-Gln-Leu-Gln-Trp-Leu. The protein of the present invention is obtained in substantially pure form at high activity recovery, and is excellent in inducing necrosis of tumors with no toxicity upon the normal tissues of the living body. The protein of the present invention is thermally stable and, therefore, when preparation of pharmaceutical compositions is conducted, the protein of the present invention can be stably formulated into compositions.
This invention relates to a mounting system (1) inserted between an aircraft engine and a rigid structure of an attachment strut, the system particularly comprising a thrust resistance device (20). The thrust resistance device (20) comprises two lateral actuators (30) each provided with a rod (34) in which a forward end (34b) is a piston located inside a chamber (38) of a central casing (22) of the engine, the chamber (38) comprising a forward compartment (40) and an aft compartment (42). Moreover, the thrust resistance device (20) comprises a device (32) including a piston (48) fixed to the forward mount (16) and located inside a chamber (50) fixed to the central casing, the chamber (50) comprising a forward compartment (52) and an aft compartment (54), the forward compartment (52) of the chamber (50) being hydraulically connected to the aft compartments (42) of the actuators (30).
