Circuit apparatus and method for electrothermal treatment of cancer eye

Claims

I claim:

1. In an apparatus for electrothermal treatment of unhealthy tissue, a circuit for producing flow of a high frequency current through the unhealthy tissue to heat it without damaging adjacent healthy tissue, said electrothermal apparatus including first and second spaced current probes each having a contact surface for electrically contacting the surface of said unhealthy tissue to thereby conduct said high frequency electrical current through said unhealthy tissue, said electrothermal treatment apparatus also including output oscillating circuit means for producing a high frequency voltage signal for application across said first and second current probes to cause said high frequency current to flow through said unhealthy tissue if said contact surfaces are held sufficiently forcefully against the surface of said tissue, said output oscillating circuit means including a control input for receiving a duty cycle signal for regulating the duty cycle of the flow of high frequency current.

said circuit comprising in combination:

(a) temperature sensing means for sensing the temperature of said first current probe to produce a first electrical signal representative of the temperature of said first probe;

(b) voltage controlled oscillating circuit means responsive to said first electrical signal for producing a second electrical signal, said second electrical signal being an AC signal, and continuously varying the frequency of said second electrical signal approximately proportionately to variations in the temperature of said first current probe, said voltage controlled oscillating circuit means including means for causing said second electrical signal to have a frequency that varies continuously between first and second predetermined audio frequencies as the temperature of said first current probe varies between first and second predetermined temperature levels;

(c) regulating circuit means for generating said duty cycle signal for application to said control input of said oscillating circuit means;

(d) delay circuit means for reducing the duty cycle of said duty cycle signal applied to said control input to a predetermined duty cycle for a predetermined initial time period after initial application of operating power to said circuit in order to prevent initial overheating of said unhealthy tissue due to thermal lag between heating of said unhealthy tissue by said high frequency current and heating of said first current probe;

(e) audio transducer means responsive to said second electrical signal for producing an audible sound, said audio transducer means including means for causing the pitch of said audible sound to represent the temperature of said first current probe and hence the temperature of said unhealthy tissue when said unhealthy tissue is being heated by said high frequency current,

whereby the user of said electrothermal treatment apparatus can immediately detect the reduction in the pitch of said audible sound caused by the user's failure to hold said contact surfaces adequately forcefully against said unhealthy tissue.

2. The apparatus as recited in claim 1 wherein said output oscillating circuit means halts oscillation of said output oscillating circuit means when said control input is at a first signal level, and wherein said regulating circuit means is responsive to said first electrical signal and coupled to said control input for varying said control input for periodically halting oscillating of said putput oscillating circuit means in order to reduce the amount of heating of said unhealthy tissue by said high frequency current.

3. The apparatus as recited in claim 2 wherein said regulating circuit means is responsive to said delay circuit means for causing the duty cycle of said duty cycle signal to have said predetermined duty cycle during said predetermined initial time period regardless of the temperature of said first current probe.

4. The apparatus as recited in claim 1 further including threshold circuit means responsive to said first electrical signal for producing a third electrical signal if said first electrical signal exceeds a predetermined level, and timing circuit means responsive to said third electrical signal coupled to said audio transducer means for effecting interruption of said audible sound at a predetermined repetition rate to cause said audio transducer means to produce a beeping sound that indicates to the user how long said tissue has been maintained at a temperature in excess of said first predetermined temperature level.

5. The apparatus of claim 3 wherein said voltage controlled oscillating circuit means includes ramp circuit means for generating a ramp voltage waveform and wherein said regulating circuit means includes first comparison circuit means responsive to said ramp voltage waveform and responsive to said first electrical signal for producing a duty cycle modulation signal when said ramp voltage exceeds the voltage of said first electrical signal and applying said duty cycle modulation signal to said control input.

6. The apparatus of claim 3 including power source switch means that, when closed, supplies operating power to said apparatus, wherein said delay circuit means includes circuit means for producing a relatively slowly rising signal, and comparison circuit means for comparing said relatively slowly rising signal with a predetermined threshold to produce a third electrical signal, said regulating circuit means being responsive to said third electrical signal to cause said duty cycle signal to have said predetermined duty cycle.

7. The apparatus of claim 6 wherein said regulating circuit means includes an integrating circuit means for producing an average voltage of said duty cycle signal, a voltage scaling circuit responsive to said first electrical signal for producing a fourth electrical signal, and second comparison circuit means responsive to said fourth electrical signal for producing a signal which is conducted to an input of said first comparison circuit means in order to cause said first comparison circuit means to increase or decrease the duty cycle of said duty cycle signal as necessary to cause said average of said duty cycle signal to be equal to the voltage of said fourth electrical signal.

8. The apparatus of claim 1, including a transfomer having a primary winding and a secondary winding and having output terminals, wherein said oscillating circuit means includes ring oscillator circuit means for producing first and second substantially nonoverlapping signals and first and second field effect transistors responsive, respectively, to said first and second substantially nonoverlapping signals and having their drain electrodes coupled, respectively, to the primary winding terminals of said transformer, the output terminals of said transformer being coupled to said first and second current probes, respectively.

9. The apparatus of claim 1 wherein said high frequency voltage signal has a frequency of approximately two megahertz.

10. The apparatus as recited in claim 2 wherein said regulating circuit means operates to reduce the amount of heating of said tissue by said high frequency current in the temperature range from approximately 50.degree. C. to 55.degree. C.

11. The apparatus as recited in claim 1 wherein said first and second predetermined frequencies are approximately 1000 and 4000 cycles per second, respectively, and said first and second predetermined temperature levels are approximately 50.degree. C. and 55.degree. C., respectively.

12. A method of operating an apparatus to electrothermally treat unhealthy tissue by conducting high frequency current through first and second current probes and through said unhealthy tissue to cause heating of said unhealthy tissue to at least a first predetermined temperature for at least a predetermined amount of time in order to kill said unhealthy tissue without causing undue damage to adjacent healthy tissue, said method comprising the steps of:

(a) pressing said first and second current probes against the surface of said unhealthy tissue with sufficient force to reduce the contact resistance between said first and second probes and said unhealthy tissue to a level that enables a predetermined amount of said high frequency current to flow through the unhealthy tissue disposed between said first and second current probes;

(b) applying electrical power to a circuit that produces a high frequency voltage across said first and second current probes; to cause said high frequency insert to flow, the voltage and current being at a particular duty cycle unhealthy tissue between said first and second current probes to the other of said first and second current probes to cause heating of that unhealthy tissue, heat from said unhealthy tissue flowing by thermal conduction to said first current probe and raising the temperature thereof;

(d) sensing the temperature of said first probe to produce a first electrical signal;

(e) producing an audio frequency signal representative of the temperature of said first current probe and applying said audio frequency signal to an audio frequency sound transducer which produces an audible sound, the pitch of which is representative of the temperature of said first current probe, the pitch of said sound gradually increasing and informing a person operating said apparatus whether that person is applying adequate pressure on both of said first and second current probes to cause adequate electrical current to flow through said first and second current probes and said unhealthy tissue to raise the temperature thereof at a satisfactory rate; and

(f) limiting the duty cycle of said high frequency voltage and said high frequency current to a predetermined duty cycle for a predetermined amount of time after the beginning of said conducting of said high frequency current through said unhealthy tissue, said predetermined duty cycle having a value which prevents initial heating of said unhealthy tissue at a rate that excessively exceeds the rate of thermal conductive heating of said first probe by the heated unhealthy tissue.

13. The method of claim 12 further including the step of regulating said duty cycle of said high frequency voltage in order to correspondingly reduce the amount of heat energy produced by said high frequency current in said tumorous or cancerous tissue as the temperature of said first probe increases from said first predetermined temperature to a second predetermined temperature.

14. The method of claim 13 wherein said first predetermined temperature is approximately 50.degree. C. and said second predetermined temperature is approximately 55.degree. C.

15. The method of claim 12 including the method of periodically interrupting the energization of said transducer producing said sound in response to said first electrical signal after the temperature of said first probe exceeds a predetermined temperature level to enable the user of said apparatus to count the number of interruptions of said sound to determine the amount of time that said tissue is maintained at a temperature above said first predetermined temperature.

16. The method of claim 13 including the method of generating a ramp voltage waveform, generating a scaled voltage signal that is proportional to said first signal, comparing said ramp voltage waveform with said scaled voltage signal to produce a duty cycle modulation signal when said ramp voltage exceeds said first signal, and interrupting said high frequency voltage in response to said duty cycle modulation signal.

17. The method of claim 16 wherein said comparing of said ramp voltage waveform with said scaled voltage includes averaging said duty cycle modulation signal and comparing the resulting averaged duty cycle modulation signal with said scaled voltage to produce a comparison signal and inputting said ramp voltage waveform and said comparison signal into a comparator circuit.