4-(8-bromodibenz[b,f]oxepin-10-yl)-1,2,3,6-tetrahydro-1-methylpyridine and 4-(2-bromodibenzo[a,d]cyclophetatriene-11-yl)-1,2,3,6-tetrahydro-1-methy lpyridine for dermal inflammation
A method of treating inflammation which comprises topically administering to the affected area a compound of the formula ##STR1## or a pharmaceutically acceptable addition salt thereof, is described.
Novel thienobenzoxepins and naphthothiophenes, intermediates and processes for the preparation thereof, and methods of alleviating pain utilizing compounds or compositions thereof are disclosed.
![4-(8-bromodibenz[b,f]oxepin-10-yl)-1,2,3,6-tetrahydro-1-methylpyridine and 4-(2-bromodibenzo[a,d]cyclophetatriene-11-yl)-1,2,3,6-tetrahydro-1-methy lpyridine for dermal inflammation - US Patent 4595689 - Page 1](http://www.wikipatents.com/4-8-bromodibenzbfoxepin-10-yl-1236-tetrahydro-1-methylpyridine-and-4-2-bromodibenzoadcyclophetatriene-11-yl-1236-tetrahydro-1-methy-lpyridine-for-dermal-inflammation/T/US4595689-1.jpg "4-(8-bromodibenz[b,f]oxepin-10-yl)-1,2,3,6-tetrahydro-1-methylpyridine and 4-(2-bromodibenzo[a,d]cyclophetatriene-11-yl)-1,2,3,6-tetrahydro-1-methy lpyridine for dermal inflammation - US Patent 4595689 - Page 1")
![4-(8-bromodibenz[b,f]oxepin-10-yl)-1,2,3,6-tetrahydro-1-methylpyridine and 4-(2-bromodibenzo[a,d]cyclophetatriene-11-yl)-1,2,3,6-tetrahydro-1-methy lpyridine for dermal inflammation - US Patent 4595689 - Page 2](http://www.wikipatents.com/4-8-bromodibenzbfoxepin-10-yl-1236-tetrahydro-1-methylpyridine-and-4-2-bromodibenzoadcyclophetatriene-11-yl-1236-tetrahydro-1-methy-lpyridine-for-dermal-inflammation/T/US4595689-2.jpg "4-(8-bromodibenz[b,f]oxepin-10-yl)-1,2,3,6-tetrahydro-1-methylpyridine and 4-(2-bromodibenzo[a,d]cyclophetatriene-11-yl)-1,2,3,6-tetrahydro-1-methy lpyridine for dermal inflammation - US Patent 4595689 - Page 2")
![4-(8-bromodibenz[b,f]oxepin-10-yl)-1,2,3,6-tetrahydro-1-methylpyridine and 4-(2-bromodibenzo[a,d]cyclophetatriene-11-yl)-1,2,3,6-tetrahydro-1-methy lpyridine for dermal inflammation - US Patent 4595689 - Page 3](http://www.wikipatents.com/4-8-bromodibenzbfoxepin-10-yl-1236-tetrahydro-1-methylpyridine-and-4-2-bromodibenzoadcyclophetatriene-11-yl-1236-tetrahydro-1-methy-lpyridine-for-dermal-inflammation/T/US4595689-3.jpg "4-(8-bromodibenz[b,f]oxepin-10-yl)-1,2,3,6-tetrahydro-1-methylpyridine and 4-(2-bromodibenzo[a,d]cyclophetatriene-11-yl)-1,2,3,6-tetrahydro-1-methy lpyridine for dermal inflammation - US Patent 4595689 - Page 3")
![4-(8-bromodibenz[b,f]oxepin-10-yl)-1,2,3,6-tetrahydro-1-methylpyridine and 4-(2-bromodibenzo[a,d]cyclophetatriene-11-yl)-1,2,3,6-tetrahydro-1-methy lpyridine for dermal inflammation - US Patent 4595689 - Page 4](http://www.wikipatents.com/4-8-bromodibenzbfoxepin-10-yl-1236-tetrahydro-1-methylpyridine-and-4-2-bromodibenzoadcyclophetatriene-11-yl-1236-tetrahydro-1-methy-lpyridine-for-dermal-inflammation/T/US4595689-4.jpg "4-(8-bromodibenz[b,f]oxepin-10-yl)-1,2,3,6-tetrahydro-1-methylpyridine and 4-(2-bromodibenzo[a,d]cyclophetatriene-11-yl)-1,2,3,6-tetrahydro-1-methy lpyridine for dermal inflammation - US Patent 4595689 - Page 4")
![4-(8-bromodibenz[b,f]oxepin-10-yl)-1,2,3,6-tetrahydro-1-methylpyridine and 4-(2-bromodibenzo[a,d]cyclophetatriene-11-yl)-1,2,3,6-tetrahydro-1-methy lpyridine for dermal inflammation - US Patent 4595689 - Page 5](http://www.wikipatents.com/4-8-bromodibenzbfoxepin-10-yl-1236-tetrahydro-1-methylpyridine-and-4-2-bromodibenzoadcyclophetatriene-11-yl-1236-tetrahydro-1-methy-lpyridine-for-dermal-inflammation/T/US4595689-5.jpg "4-(8-bromodibenz[b,f]oxepin-10-yl)-1,2,3,6-tetrahydro-1-methylpyridine and 4-(2-bromodibenzo[a,d]cyclophetatriene-11-yl)-1,2,3,6-tetrahydro-1-methy lpyridine for dermal inflammation - US Patent 4595689 - Page 5")
![4-(8-bromodibenz[b,f]oxepin-10-yl)-1,2,3,6-tetrahydro-1-methylpyridine and 4-(2-bromodibenzo[a,d]cyclophetatriene-11-yl)-1,2,3,6-tetrahydro-1-methy lpyridine for dermal inflammation - US Patent 4595689 - Page 6](http://www.wikipatents.com/4-8-bromodibenzbfoxepin-10-yl-1236-tetrahydro-1-methylpyridine-and-4-2-bromodibenzoadcyclophetatriene-11-yl-1236-tetrahydro-1-methy-lpyridine-for-dermal-inflammation/T/US4595689-6.jpg "4-(8-bromodibenz[b,f]oxepin-10-yl)-1,2,3,6-tetrahydro-1-methylpyridine and 4-(2-bromodibenzo[a,d]cyclophetatriene-11-yl)-1,2,3,6-tetrahydro-1-methy lpyridine for dermal inflammation - US Patent 4595689 - Page 6")
![4-(8-bromodibenz[b,f]oxepin-10-yl)-1,2,3,6-tetrahydro-1-methylpyridine and 4-(2-bromodibenzo[a,d]cyclophetatriene-11-yl)-1,2,3,6-tetrahydro-1-methy lpyridine for dermal inflammation - US Patent 4595689 Drawing](http://www.wikipatents.com/us/4595689.png "4-(8-bromodibenz[b,f]oxepin-10-yl)-1,2,3,6-tetrahydro-1-methylpyridine and 4-(2-bromodibenzo[a,d]cyclophetatriene-11-yl)-1,2,3,6-tetrahydro-1-methy lpyridine for dermal inflammation - US Patent 4595689 Drawing")
