N.sup.6 -Acenaphthyl adenosines and analogs thereof and pharmaceutically acceptable acid addition salts having highly desirable blood pressure lowering properties, processes for their manufacture and pharmaceutical compositions and methods for using said compounds and compositions are described.
This application is a divisional of U.S. application Ser. No. 771,591, filed Sept. 5, 1985, which is a continuation-in-part of Ser. No. 665,195, filed Oct. 26, 1984, now abandoned.
Method for treating congestive heart failure by administration of N.sup.6 -[(1,2-dihydro-1-acenaphthylenyl)-methyl]adenosine or a pharmaceutically acceptable salt thereof.
The present invention relates to N-(6)-substituted adenosine compounds of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein Z is an amine and R.sub.1 and R.sub.2 are independently hydrogen, hydroxyl, halogen, alkyl, phenyl, alkoxy, morpholino, piperidino, piperazino, phenoxy, thiophenoxy or amino optionally substituted by alkyl, aralkyl or phenyl.
