A profile consisting of two sections (1, 2) joined together. One section (1) is an open hollow section with an inner contour which is uniform with and somewhat bigger than the outer contour of the other section (2) and where the opening (4) is arranged so that two identical profiles can be telescoped into each other. According to the invention the other section (2) is solid or a closed hollow section. The opening (4) of the open hollow section (1), has a width which is somewhat bigger than the wall thickness of the hollow section (1) in an area (5), which is situated on the opposite side relative to the opening (4) of the connection (3) between the sections (1, 2). Thus, it is achieved that the open hollow sections (1) of the profiles substantially, completely surround the other sections (2) of the profiles, respectively, when two identical profiles are telescoped into each other.
This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as alpha 1a adrenergic receptor antagonists. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds are selective in their ability to relax smooth muscle tissue enriched in the alpha 1a receptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha relductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia are achieved.
