A specimen trap has first and second fluid chambers, an inlet tube for introducing fluid from the body into the first chamber, the walls of the trap defining a port substantially larger than the flow cross-section of the inlet tube for flow of fluid from the first chamber to the second chamber, and an outlet tube for removing fluid from the second chamber. The outlet tube projects into the second chamber and terminates therewithin at a position spaced from the walls of the chamber. When the chamber is turned to a position with outlet tube down, the outlet tube projection defines, with the second chamber, a fluid retaining volume in which a pre-selected minimum volume of collected fluid specimen is retained. A filter is disposed across the port to filter fluid flowing therethrough, and is supported at a position spaced from the outer walls defining the second chamber to inhibit back-flow of fluid through the filter that could resuspend the collected particles despite change in trap orientation. As normal flow through the trap proceeds, suspended particles can be isolated and a quantity of filtered liquid retained in close, humidifying relationship thereto, in a manner in which substantial resuspension of the isolated solid particles is inhibited despite change in orientation of the trap during handling prior to laboratory analysis of the specimen.
An apparatus for collecting and testing multiple biological markers comprising a tubular compartmentalized container holding covalently bound antigen beads and correlating anti-antibody beads contained in separated compartments. The biological fluid, namely urine, is collected in the tubular container and is forced to flow through the separated compartment of the compartmentalized container so that predetermined ligands become attached to the bead ligands to obtain a plurality of biological markers.
The present invention is directed towards an apparatus and a method which can use immunoassay in sample treatment apparatus for diagnostic and testing purposes of dialysis fluid or urine by concentrating the urinary sediments on a first membrane and concentrating bacteria on a second membrane. Urine is transported through the tubular container under pressure to flow through the sample container which separately screens off the urinary sediments and the bacteria for collection and testing.
A filter for obstetrical fluids and particulate matter having an enclosure containing a first chamber and a second chamber is disclosed. The first chamber has a solid partition forming first and second cavities in the first chamber. The first cavity has an inlet and the second cavity has an outlet. The second chamber contains a filter and the edge of the partition is pressed against the surface of the filter.
An apparatus for testing biological molecular indicators in urine comprising a tubular container with a plunger assembly and associated testing assembly. Urine is collected in the tubular container mixed with labelled antibodies and is caused by the plunger assembly to flow against a testing surface provided with immobilized antibodies which capture antigens complexed with labelled antibodies. The enzymes of the labelled antibodies are colored by a reactant solution to indicate the presence or absence of specific antigens in the tested urine.
A method for testing for biological molecular indicators in urine. Urine is transported through a sample container under pressure to flow through the sample container so that antigens in the urine are collected and bound on antibodies immobilized on the beads to form antigen-antibody complex. The beads are washed to remove cell debris and charged molecules and a specific prelabelled antibody solution is passed through the sample container with the prelabelled antibodies attaching to a receptor site on the captured antigen to form an antibody-antigen-prelabelled antibody sandwich complex. This sandwich complex is washed to remove cell debris and charged molecules and mixed with a color reagent solution which reacts with the prelabelled antibody to produce an color indicating the presence of a specific cancer antigen.
