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Multi-wavelength oximeter having a means for disregarding a poor signal    
United States Patent4714341   
Link to this pagehttp://www.wikipatents.com/4714341.html
Inventor(s)Hamaguri; Kenji (Minamikawachi, JP); Sakai; Takao (Habikino, JP)
AbstractAn oximeter for measuring oxygen saturation in arterial blood includes a light source for projecting light to a body member to be measured, a light responsive circuit for receiving the light which has transmitted through said body member and for generating at least first, second and third signals at three different wavelengths, and a calculator for calculating at least first SaO.sub.2 data using first and second signals and second SaO.sub.2 data using first and third signals. It is detected whether or not a difference between the first and second SaO.sub.2 data is within a predetermined level. When the difference is within the predetermined level, it is assumed that the first and/or second SaO.sub.2 data are valid, but if not, they are assumed as invalid.
   














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Drawing from US Patent 4714341
Multi-wavelength oximeter having a means for disregarding a poor signal - US Patent 4714341 Drawing
Multi-wavelength oximeter having a means for disregarding a poor signal
Inventor     Hamaguri; Kenji (Minamikawachi, JP); Sakai; Takao (Habikino, JP)
Owner/Assignee     Minolta Camera Kabushiki Kaisha (Osaka, JP)
Patent assignment
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Publication Date     December 22, 1987
Application Number     06/704,772
PAIR File History     Application Data   Transaction History
Image File Wrapper   Patent Term   Fees
Litigation
Filing Date     February 21, 1985
US Classification     356/41 600/310
Int'l Classification     G01N 033/16
Examiner     Rosenberger; R. A.
Assistant Examiner    
Attorney/Law Firm     Price, Gess & Ubell
Address
Parent Case    
Priority Data     Feb 23, 1984[JP]59-33952 Mar 12, 1984[JP]59-47769
USPTO Field of Search     356/41 356/320 356/406 356/407 356/414 356/416 356/417 356/419 128/633 128/664 128/665 128/666
Patent Tags     multi-wavelength oximeter disregarding poor signal
   
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ReferenceRelevancyCommentsReferenceRelevancyComments
4586513
Hamaguri
600/326
May,1986

[0 after 0 votes]
4453218
Sperinde
600/331
Jun,1984

[0 after 0 votes]
4407290
Wilber
600/330
Oct,1983

[0 after 0 votes]
4167331
Nielsen
356/39
Sep,1979

[0 after 0 votes]
4114604
Shaw
600/339
Sep,1978

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4086915
Kofsky
600/330
May,1978

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3998550
Konishi
356/39
Dec,1976

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Shaw
600/323
Feb,1972

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What is claimed is:

1. An oximeter for measuring oxygen saturation in arterial blood comprising:

light source means for projecting light to a body member to be measured;

light responsive means for receiving the light which has transmitted through said body member and for generating at least first, second and third signals at three different wavelengths;

calculating means for calculating at least first oxygen saturation data using first and second signals and second oxygen saturation data using first and third signals;

determining means for determining whether or not a difference between said first and second oxygen saturation data is within a predetermined level; and

means for designating said first and/or second oxygen saturation data as valid when said difference is within said predetermined level, and as invalid when said difference is not within said predetermined level.

2. An oximeter as claimed in claim 1, wherein said first, second and third signals are pulsating signals which correspond to a heart beat.

3. An oximeter as claimed in claim 1, wherein each of said first, second and third signals include information of a body member in a bloodless condition and also in a blood filled condition.

4. An oximeter as claimed in claim 1, further comprising means for controlling said light source means, light responsive means, calculating means, determining means and designating means to operate in a programmed manner to complete one cycle, and for controlling the same to repeat the cycle.

5. An oximeter as claimed in claim 4, further comprising display means for displaying said valid oxygen saturation data.

6. An oximeter as claimed in claim 5, wherein said display means is a CRT.

7. An oximeter as claimed in claim 5, wherein said display means displays said valid oxygen saturation data in a graph having an axis of time and axis of oxygen saturation data.

8. An oximeter as claimed in claim 5, wherein said display means displays said valid oxygen saturation data in a digital number.

9. An oximeter as claimed in claim 4, further comprising means for obtaining an average oxygen saturation.

10. An oximeter as claimed in claim 9, wherein said average oxygen saturation obtaining means comprises:

detecting means for detecting the valid oxygen saturation data obtained in the recent predetermined number of cycles;

means for counting the number of valid oxygen saturation data detected by said detecting means;

and an averaging means for calculating an arithmetic average of a predetermined number valid oxygen saturation data of those detected by said detecting means when said number counted by said counting means is greater than a predetermined number.

11. An oximeter as claimed in claim 1, further comprising means for setting upper and lower limits for said valid oxygen saturation data, and warning means for producing a warning when said valid oxygen saturation data does not fall in a range between said upper and lower limits.

12. An oximeter for measuring oxygen saturation in arterial blood comprising:

light source means for projecting light to a body member to be measured;

light responsive means for receiving the light which has transmitted through said body member and for generating at least first, second and third signals at three different wavelengths;

detecting means for detecting whether or not an amplitude level of each of said first, second and third signals is within a predetermined range between upper and lower levels;

selecting means for selecting first, second and third signals which have been detected by said detecting means;

calculating means for calculating at least first oxygen saturation data using selected first and second signals and second oxygen saturation data using selected first and third signals;

determining means for determining whether or not a difference between said first and second oxygen saturation data is within a predetermined level; and

means for designating said first and/or second oxygen saturation data as valid when said difference is within said predetermined level, and as invalid when said difference is not within said predetermined level.
 Description Submit all comments and votes
 


BACKGROUND OF THE INVENTION

1. Field of the Invention

The present invention relates to an oximeter and, more particularly, to an apparatus for measuring the degree of oxygen saturation of arterial blood (hereinafter also referred to as SaO.sub.2) a non-invasive manner.

2. Description of the Prior Art

The oximeter of non-invasive type generally has a source of a light from which a light is directed to a body member of the subject, such as a finger or ear lobe. The light passes through the body member and is then detected by the detector. The amount of light absorbed by the body member as light is transmitted through it is a function of the attenuation which is dependent on the amount of oxygenated hemoglobin in the arterial blood in the body member. Accordingly, by measuring the transmitted light, oxygen saturation (SaO.sub.2) in the arterial blood can be determined.

According to the prior art oximeter of the above described type, the active motion of the body member, such as a movement of the body member or an irregular pulse of blood pressure causes an undesirable change in the light amount measured by the detector, thus resulting in undesirable noise signal in the detected signal. Since it is impossible to stop the active motion of the body member, a means for detecting the active motion is provided. When the detecting means detects the active motion, the measured result is ignored. Here, the problem is to provide such a detecting means which has a high accuracy in detecting the active motion in the body member.

According to a first prior art oximeter, the active motion is detected by the detection of a sudden and great change in the amplitude of the pulse signal. In this case, the active motion with a sudden change can be detected, but the active motion that changes gradually and incessantly can not be detected.

According to a second prior art oximeter, the active motion is detected by the detection of a difference in the step-up time, or step-down time, between the pulse signal under active motion and pulse signal under a steady condition. However, because of wide variations between patients in such a step-up time or step-down time, and even in the same patient due to the environmental change, the accuracy of the detected result is very poor.

According to a third prior art oximeter, the active motion is detected by the detection of change in the pulse rate. This oximeter, however, can not detect the active motion when the active motion occurs periodically.

An improved oximeter, which is invented by one of the present invention, Kenji HAMAGURI, and is assigned to the same assignee, is disclosed in Japanese Patent Laid-open Publication (Tokkaisho) No. 55-120858. According to this publication, the light passed through the body member is detected at three different wavelengths. Using the detected amount of light Ea1, Ea2 and Ea3 at three different wavelengths, the amount of absorption Eb1, Eb2 and Eb3 by the blood in the body member is calculated for each of the three wavelengths. Then, differences Ec1 and Ec2 are obtained through the calculations:

Ec1=Eb1-Eb3

and

Ec2=Eb2-Eb3.

Then, using the obtained differences Ec1 and Ec2, the degree of oxygen saturation of arterial blood (SaO.sub.2) is obtained.

Even in this improved oximeter, since the oxygen saturation (SaO.sub.2) is calculated using the signal which has been already influenced by the active motion of the body, the influence of the active motion can not be completely removed from the result obtained from the improved oximeter. In the case where the action motion is great, the obtained result will be very poor in reliability.

Also, according to the prior art of noninvasive type, a digital display device and/or an analog current meter are employed for the indication of oxygen saturation (SaO.sub.2) and pulse rate in the instantaneous values or in the averaged values. By the continuous watch on the patient's oxygen saturation using the oximeter of noninvasive type, the sudden condition change of the patient can be catched easily. However, with the digital display device or analog current meter itself, it is difficult to know the gradual condition change of the patient.

Furthermore, according to the prior art oximeter, the indication through the digital display device and/or the analog current meter is effected after a certain period of time, but when it is detected that the measured result does not have a sufficient accuracy, the indication is skipped. When the skipping takes place for a number of times frequently, the indication on the display is effected irregularly.

Accordingly, because of the disadvantages mentioned above, it has been difficult to obtain accurate and trustworthy results from the oximeter of the prior art.

SUMMARY OF THE INVENTION

The present invention has been developed with a view to substantially solving the above described disadvantages and has for its essential object to provide an improved oximeter of non-invasive type which can provide a degree of oxygen saturation of arterial blood (SaO.sub.2) with a high accuracy.

It is also an essential object of the present invention to provide an oximeter of the above described type which can present the obtained data in various fashions to utilize the data in every possible way.

In accomplishing these and other objects, an oximeter according to the present invention comprises a light source for projecting light to a body member to be measured, a light responsive circuit for receiving the light which has transmitted through said body member and for generating at least first, second and third signals at three different wavelengths, and a calculator for calculating at least a first SaO.sub.2 data using first and second signals and second a SaO.sub.2 data using first and third signals. Then, it is detected whether or not a difference between the first and second SaO.sub.2 data is within a predetermined level. When the difference is within the predetermined level, it is assumed that the first and/or second SaO.sub.2 data are valid, but if not, they are assumed as invalid.

BRIEF DESCRIPTION OF THE DRAWINGS

These and other objects and features of the present invention will become apparent from the following description taken in conjunction with preferred embodiments thereof with reference to the accompanying drawings, throughout where like parts are designated by like reference numerals, and in which:

FIG. 1a is a block diagram of an oximeter according to a first embodiment of the present invention;

FIG. 1b is a graph showing waveforms obtained from major points in the circuit of FIG. 1a;

FIG. 2 is a diagrammatic view of a light source used in the circuit of FIG. 1a;

FIG. 3 is a block diagram showing a detail of circuits from photoelectric cells to logarithmic amplifiers;

FIG. 4 is a circuit diagram showing a detail of logarithmic amplifiers and the associated parts thereto;

FIG. 5 is a circuit diagram showing an example of a standard full-wave rectifier;

FIG. 6 is a graph showing a pulsating signal and a rectified signal, both carried on unwanted offset voltage;

FIG. 7 is a circuit diagram showing an improved full-wave rectifier;

FIG. 8 is a graph showing a relationship between a difference .vertline.SaO.sub.2 (1)-SaO.sub.2 (2).vertline. and true SaO.sub.2 (2);

FIG. 9 is a plan view of a control panel;

FIGS. 10a-10e taken together as shown in FIG. 10 show a flow chart for the control operation of calculation carried out in the oximeter of the first embodiment;

FIG. 11 is a flow chart showing an operation for setting upper and lower limits for SaO.sub.2 (2) and pulse rate;

FIG. 12 is a graph showing a relationship between calculated SaO.sub.2 and a square of amplitude ratio;

FIG. 13 is a block diagram of an oximeter according to a second embodiment of the present invention; and

FIG. 14 is a flow chart for the control operation of calculation carried out in the oximeter of FIG. 13.

THEORY OF SaO.sub.2 MEASURING ACCORDING TO THE INVENTION

Before the description proceeds to the preferred embodiments, the theory of measuring the degree of oxygen saturation of arterial blood (SaO.sub.2) is described.

When light transmits through the body member, it is absorbed and scattered by blood, muscle, and other members constituting the body member. Thus the transmitted light is attenuated. Since the arterial blood is pulsating, its volume at a place where the light transmits changes periodically. Thus, the degree of attenuation of the transmitted light also changes periodically. The intensity Iw of the light, having a wavelength w, transmitted through the body member can be given as follows:

Iw=Iow.times.Ftw.times.Fvw.times.f(Qw)e.sup.-g(Qw)(d+.DELTA.d),

wherein Iow is an intensity of light directed to the body member; Ftw is a transmittance of a bloodless body member; Fvw is a transmittance of a body member with venous blood; Qw is an absorption coefficient of light having the wavelength w with arterial blood; f(Qw) and g(Qw) are functions with a variable Qw; d+.DELTA.d is a thickness of the body member; and .DELTA.d is the change in the thickness of the body member that takes place periodically.

A DC component Yw in the logarithmically compressed values of Iw can be given:

Yw=-g(Qw).DELTA.d.

Since g(Qw) is approximately proportional to the square root of Qw, the above equation may be written:

Yw.sup.2 =kwQw(.DELTA.d).sup.2,

wherein kw is a constant determined dependently on the wavelength w. The absorption coefficient Qw can be given: ##EQU1## in which

Ct=CHbo.sub.2 +CHb

and

S=CHbo.sub.2 /Ct=CHbo.sub.2 /(CHbo.sub.2 +CHb),

and wherein CHbo.sub.2 and CHb are the amounts of oxyhemoglobin and deoxyhemoglobin, respectively, in a unit volume; and EwHbo.sub.2 and EwHb are absorption coefficients of the light with the wavelength w in oxyhemoglobin and deoxyhemoglobin, respectively. Accordingly, Yw.sup.2 can be given as follows:

Yw.sup.2 =kwCt[S(EwHbo.sub.2 -EwHb)+EwHb](.DELTA.d).sup.2.

By obtaining two different DC components Yw1 and Yw2 at two different wavelengths w1 and w2, it is possible to calculate the ratio S in a manner described below.

Since

(Yw1).sup.2 =kw1Ct[S(Ew1Hbo.sub.2 -Ew1Hb)+Ew1Hb](.DELTA.d).sup.2

and

(Yw2).sup.2 =kw2Ct[S(Ew2Hbo.sub.2 -Ew2Hb)+Ew2Hb](.DELTA.d).sup.2,

we obtain ##EQU2## By selecting a certain light having a wavelength w1 which satisfies an equation:

Ew1Hbo.sub.2 =Ew1Hb,

the above equation can be simplified as: ##EQU3## Since the degree of oxygen saturation of arterial blood (SaO.sub.2) can be defined as

SaO.sub.2 =S.times.100(%),

the above equation may be written as: ##EQU4## wherein A and B are amounts which can be obtained from the optical characteristics of the blood. When A and B are fixed, SaO.sub.2 is in relation to Yw2/Yw1. Therefore, a term "SaO.sub.2 data" represents not only A.times.(Yw2/Yw1).sup.2 +B, but also (Yw2/Yw1).sup.2 and Yw2/Yw1.

DESCRIPTION OF THE PREFERRED EMBODIMENTS

Referring to FIG. 1a, a body member F, such as a finger, is steadily held between a light source 1, such as a halogen lamp, and a light receiver 2. Light receiver 2 is sensitive to light at three different wavelengths, which are, e.g., 805, 710 and 650 nanometers. It is to be noted that these figures are given merely as an example, and, therefore, any other figures can be used. Thus, light receiver 2 generates three different signals representing the intensity of light at three different wavelengths. The generated signals are applied to logarithmic circuits 5, 6 and 7, respectively. According to a preferred embodiment, light receiver 2 includes three photoelectric cells 36, 37 and 38, shown in FIG. 3, which are coupled to I/V (current-to-voltage) converters 39, 40 and 41, respectively. Thus, converters 39, 40 and 41 generate voltage signals representing the light intensity at wavelengths 805, 710 and 650 nanometers, respectively. These signals produced from I/V converters 39, 40 and 41 are substantially equal to the signals produced from light receiver 2, and are applied to logarithmic amplifiers 42, 43 and 44 provided in logarithmic circuits 5, 6 and 7, respectively. The signals produced from light receiver 2 are composite signal having both AC and DC components, as shown in FIG. 1b, first row. As indicated therein, each signal is carried on a different DC level y and has a different amplitude x of fluctuation. The fluctuation is caused by the heart pulsation of the body.

The difference in the DC level is caused by the difference of the light intensity at three different wavelengths. Therefore, it is necessary to compensate the voltage signals obtained from I/V converters 39, 40 and 41 in such a way that the signals are obtained in the same condition, so that three signals have the same DC level. To this end, the light from light source 1 is also applied to a monitor receiver 3 which monitors the intensity of the light at three different wavelengths, which are the same as those mentioned above.

According to the preferred embodiment, as shown in FIG. 3, monitor receiver 3 includes one photoelectric cell 34, which is coupled to an I/V converter and further to three AD/DC converters 45, 46 and 47. As will be described in detail later, AC/DC converters 45, 46 and 47 generate voltage signals indicating the intensity of direct light from light source 1 at three different wavelengths. The signals from AD/DC converters 45, 46 and 47 are applied to logarithmic amplifiers 42, 43 and 44 to change the gain therein. Thus, the voltage signals obtained from I/V converters 39, 40 and 41 can be evaluated under the same condition such that the light intensity at three different wavelengths from light source 1 are the same. Accordingly, the outputs from logarithmic amplifiers 42, 43 and 44, that is, outputs from logarithmic circuits 5, 6 and 7 are carried on the same DC level, and the signal on the DC level is identical to x/y, as indicated in FIG. 1b, second row.

Referring back to FIG. 1a, the output of logarithmic circuit 5 is applied to a low pass filter 8 for passing unwanted low frequency, such as 3 Hz, noise to a differential amplifier 11. Differential amplifier 11 also receives the signal directly from logarithmic circuit 5. Accordingly, differential amplifier 11 generates only the AC component amplified by a certain gain, as indicated in FIG. 1b, third row. The output of differential amplifier 11 is connected to a full-wave rectifier 14 which rectifies the output signal from differential amplifier 11, as indicated in FIG. 1b, fourth row, and integrates the rectified signal for a predetermined period of time, such as 1 second, repeatedly. The output of full-wave rectifier 14, such as shown in FIG. 1b, last row, is applied to a multiplexer 18.

In a similar manner, the output of logarithmic circuit 6 is connected through a low pass filter 9, a differential amplifier 12 and an full-wave rectifier 15 to multiplexer 18. Also, the output of logarithmic circuit 7 is connected through a low pass filter 10, a differential amplifier 13 and an full-wave rectifier 16 to multiplexer 18. The output of logarithmic circuit 7 is further connected to a light amount detector 17 which carries out a certain calculation to detect the amount of light received by light receiver 2. The output of light amount detector 17 is applied to multiplexer 18 for use in detecting whether or not the amount light received by receiver 2 is above a predetermined level sufficient for the SaO.sub.2 detection.

Multiplexer 18 selects one of the outputs from circuits 14, 15, 16 and 17 and sequentially transmits the selected output to an A/D (analog-to-digital) converter 20, which is defined by a double integrator 19a and a comparator 19b. Thus, the analog signal obtained from multiplexer 18 is changed to a digital signal, which is applied to a CPU (central processing unit) 26. CPU 26 also receives the signal from differential amplifier 11 through a wave-shaping circuit 21 so as to count the pulse rate of the patient.

The output of differential amplifier 11 is also applied to an ampere meter control 22 which changes the received signal to a fashion capable of driving an ampere meter 29, and to a recorder control 23 which changes the received signal to a fashion capable of operating a recorder (not shown).

CPU 26 is coupled with various devices, such as: an alarm device 30 for producing an alarm sound when an obtained signal fails to fall within a selected range; a range setting device 24 which has a number of switches for setting upper and lower limits of the range and switches for controlling the generation of alarm sound; a display device 25 for displaying various data, such as measured SaO.sub.2 and pulse rate; printer 27 for making a hard copy of the information shown on display device 25; and a digital output device 28 capable of being connected to an external device, such as a printer (not shown). CPU 26 also produces various control signals for controlling the sequence of operation of the circuits 14, 15, 16, 18 and 20, and devices 24, 25 and 30. It also carries out various control steps, which will be described later in connection with FIGS. 10a-10e, for obtaining SaO.sub.2 and pulse rate.

According to the first embodiment, the oximeter further includes a power source 31 for supplying power to the circuits and devices shown in FIG. 1a.

According to the preferred embodiment, the light source 1, shown as a halogen lamp, emits light which is directed partially to a photoelectric cell provided in monitor receiver 3, and partially directed through an optical path defined, e.g., by an optical fiber (not shown) to a light measuring portion. At the light measuring portion, the light is separated into a spectrum for obtaining the three different wavelength lights, which are directed to three different photoelectric cells 36, 37 and 38. Each of the photoelectric cells 36, 37 and 38 and the one provided in monitor receiver 3 produces a current signal which is in relation to the intensity of received light. The current signal produced from monitor receiver 3 is converted to a voltage signal in a voltage adjuster 4, and the voltage signal is applied to each of logarithmic circuits 5, 6 and 7.

Logarithmic circuit 5 receives the voltage signal from voltage adjuster 4 and also the voltage signal from light receiver 2 and produces a logarithmically compressed voltage signal carrying information about a particular wavelength light (such as light having a wavelength of 805 nanometers). Similarly logarithmic circuit 6 receives the voltage signal from voltage adjuster 4 and also the voltage signal from light receiver 2 and produces a logarithmically compressed voltage signal carrying information about a particular wavelength light (such as light having a wavelength of 710 nanometers). Furthermore, logarithmic circuit 7 receives the voltage signal from voltage adjuster 4 and also the voltage signal from light receiver 2 and produces a logarithmically compressed voltage signal carrying information about a particular wavelength light (such as light having a wavelength of 650 nonometers).

Each of the logarithmic circuits 5, 6 and 7 includes, as will be described later, a correction circuit which will eliminate the noise signal caused by the undesirable fluctuation in the light emitted from the light source. The outputs of logarithmic circuits 5, 6 and 7 are connected, respectively, to low pass filters 8, 9 and 10 and also to differential amplifiers 11, 12 and 13. The outputs of low pass filters 8, 9 and 10 are also connected to differential amplifiers 11, 12 and 13, respectively. Each differential amplifier calculates a difference between the outputs from the logarithmic circuit and the low pass filter and amplifies the obtained difference. Therefore, each differential amplifier produces a photoelectric volume pulsating signal obtained at a particular wavelength light. The pulsation in this signal is caused by the volume change of venous blood in the measuring portion and, therefore, the pulsating signal contains information about absorption coefficient of venous blood.

Differential amplifiers 11, 12 and 13 are connected, respectively, to full-wave rectifiers 14, 15 and 16, each of which is defined by a half-wave rectifier and an integrator. In each full-wave rectifier, the output signal from the differential amplifier are full-wave rectified and, thereafter, under the control of CPU 26, the rectified signal is integrated for a given time, such as 0.9 second, and thereafter, it is temporarily held for a period of time. The temporarily held signals from full-wave rectifiers 14, 15 and 16 and a signal from light amount detector 17 are selected by analog multiplexer 18 and are sequentially transmitted to double integrator 19a of A/D converter 20. Which signal multiplexer selects is controlled by CPU26.

Double integrator 19a, comparator 19b and a counter provided in CPU 26 define a double integration type A/D converter. Thus, the signals sequentially applied to double integrator 19a are converted to digital signals. After A/D conversion of each signal, the integrators in full-wave rectifiers 14, 15 and 16 are reset to discharge the integrated signal. Accordingly, each of the integrators in full-wave rectifiers 14, 15 and 16 repeats the operations of integration, hold and discharge in a predetermined frequency, and the A/D conversion is carried out in relation to such operations. Similarly, A/D conversion of output signal from light amount detector 17 is carried out repeatedly with a predetermined frequency. Each of the converted digital signals from full-wave rectifiers 14, 15 and 16 is subtracted by an offset voltage of the corresponding full-wave rectifier, which is previously converted to a digital signal and stored, thereby obtaining three amplitude signals which are in relation to the amplitude of the corresponding pulsating signal. Using the first amplitude signal, which is based on the 805 nanometer wavelength light, and the second amplitude signal, which is based on the 710 nanometer wavelength light, a first SaO.sub.2 signal (hereinafter indicated as SaO.sub.2 (1)) is obtained. Similarly, using the first amplitude signal and the third amplitude signal, which is based on the 650 nanometer wavelength light, a second SaO.sub.2 signal (hereinafter indicated as SaO.sub.2 (2)) is obtained. The obtained SaO.sub.2 (1) and SaO.sub.2 (2) are stored for a period of time. As will be described in detail later, SaO.sub.2 (1) will be used for the detection of any noise signal caused by the undesirable movement of the body member. The obtained SaO.sub.2 (1) and SaO.sub.2 (2) are calculated and renewed after every predetermined period of time. As to SaO.sub.2 (2), the newly obtained SaO.sub.2 (2) and those obtained in the several previous operations are used for obtaining an average SaO.sub.2 (2) which will be displayed through display device 25. Detailed steps for obtaining the average SaO.sub.2 (2) will be described later.

The pulsating signal produced from differential amplifier 11 is applied to wave-shaping circuit 21 in which the pulsating signal is compared with a predetermined threshold level thereby changing the pulsating signal to a binary pulse signal which takes either a HIGH level or LOW level. The binary signal is applied to CPU 26 which detects the step up and step down of the pulse for calculating the pulse repetition rate, thereby calculation the pulse rate of the patient, i.e., the number of heart beats per one minute. Similar to SaO.sub.2 (1) and SaO.sub.2 (2), the pulse rate is calculated repeatedly after predetermined periods of time and is displayed through a display device 25. A detail of calculation of pulse rate will be described later.

Ampere meter control 22 changes the pulsating signal obtained from differential amplifier 11 to a signal appropriate for driving an ampere meter 29 which indicates whether or not the pulsating signal is in a normal condition. Recorder control 23 changes the pulsating signal obtained from differential amplifier 11 to a signal appropriate to be applied to a recorder (not shown). Upon depression of a switch provided on display device 25, the information displayed on display device 25 can be immediately transferred to printer 27 for producing a hard copy of data, such as average SaO.sub.2 and pulse rate, for graph recording.

The signals representing the average SaO.sub.2 and pulse rate can be produced in a digital form through output device 28. In the case where the obtained SaO.sub.2 and pulse rate exceeds the upper limit or falls below the lower limit, it is possible that the patient is in a dangerous condition. In such a case, an alarm is required to enable a prompt action to the patient. According to the present invention, it is possible to set the upper and lower limits of each of SaO.sub.2 and pulse rate by operating various switches provided on range setting device 24. The set values are indicated on display device 25.

The alarm may be produced by way of sound from alarm device 30 and/or visual indication on display device 25. An operator can select whether or not to produce the alarm sound by a suitable switch means provided on alarm device 30. Furthermore, it is possible to change the mode of alarm device 30 such that it may be prohibited from generating a sound alarm even when the obtained result exceeds the upper limit and/or falls below the lower limit.

Light amount detector 17 is a circuit which changes the style of the output signal from logarithmic circuit 7 in a fashion applicable for the A/D conversion input signal. The signal produced from the light amount detector 17 is converted to a digital signal after every predetermined period of time, and the converted digital signal is used for determining whether or not the amount of light from light source 1 is at a reasonable level. In the case where the light from light source 1 is very strong, the operation of the photoelectric cells and logarithmic circuits 5, 6 and 7 saturates, thereby deteriorating the accuracy of the calculated result. Also, when the body member is offset the light path between light source 1 and photoelectric cells, the received light amount becomes great, thereby disabling the calculation of SaO.sub.2. A similar problem arises when the light is very weak. In this case, the signals produced from the photoelectric cells and logarithmic circuits 5, 6 and 7 are so poor that it is impossible to carry out the SaO.sub.2 measurement with a reasonable accuracy. Therefore, in order to watch and detect whether or not the received light is at a reasonable level, the output signal from light amount detector 17 is converted to a digital form and is examined whether or not it is within a predetermined range.

Referring to FIG. 2, the description is directed to the way how the noise signal, caused by the undesirable fluctuation in the light amount, is eliminated. The light from light source 1, such as from a halogen lamp 32, is directed to an end face of optical fiber 33. A reference number designated a photoelectric cell mounted in a hood 34a for monitoring the halogen light. Since photoelectric cell 34 and the end face of optical fiber 33 are positioned adjacent each other, the same type of light and approximately the same amount of light will be directed to both places. Thus, the spectral characteristics will be the same and the amount of light will be proportional between the light received by the cell 34 and by the end face of fiber 33. According to the embodiment shown in FIG. 2, only one photoelectric cell 34 is shown, but it is possible to provide a plurality of such cells. The light directed to the end face of optical fiber 33 is further directed to a measuring portion where the body member should be located. The light which has transmitted through the body member is directed to light receiver 2, at which the light is separated to spectrum for obtaining lights at three different wavelengths. The separated lights are directed to three photoelectric cells 36, 37 and 38.

Referring to FIG. 3, a circuit for receiving signals from photoelectric cells 34, 36, 37 and 38 and for producing signals having no influence of light fluctuation and carrying only the information about the attenuation of light caused only by the body member is shown. Photoelectric cell 34 of monitor circuit 3 is connected to I/V converter 35. Similarly, Photoelectric cells 36, 37 and 38 of light receiver 2 are connected to I/V converters 39, 40 and 41, respectively. Each I/V converter is provided for converting the current signal from the photoelectric cell to a voltage signal. Each of logarithmic amplifiers 42, 43 and 44 has two inputs A and B and calculates a ratio of A to B and logarithmically compresses the obtained ratio. A further detail of the circuit is given below.

The light separated at light receiver 2 and having a particular wavelength, such as 805 nanometers, impinges on photoelectric cell 36. Thus, the spectral characteristics of the light received by photoelectric cell 36 differs from that received by photoelectric cell 34 in the monitor receiver. Accordingly, the degree of change in the light amount, caused by the light intensity change of light source 1, at the photoelectric cell 36 is not the same as that at the photoelectric cell 34. Thus, the noise signals produced by the light intensity change in light source 1 can not be eliminated by merely taking a ratio between outputs from I/V converts 39 and 35 and logarithmically compressing the obtained ratio. In order to eliminate the noise signals produced by the light intensity change in light source 1 by the steps of taking a ratio between outputs from I/V converts 39 and 35 and logarithmically compressing the obtained ratio, it is necessary to match the spectrum distribution of the light directed to photoelectric cell 34 and that to photoelectric cell 36. To this end, one way is to provide a spectral divider, such as a prism, in front of photoelectric cell 34. However, this method requires three spectral dividers for monitoring lights at three different wavelengths. According to the present invention, no spectral divider is provided to photoelectric cell 34, but the signal obtained from cell 34 is electrically processed. There is a certain relationship between a ratio of change in the light amount, caused by the light intensity change of light source 1, to the intensity of light impinging on photoelectric cell 34 and a ratio of change in the light amount, caused by the light intensity change of light source 1, to the intensity of light impinging on photoelectric cell 36. More specifically, there is a certain relationship between a ratio of AC component, caused by the light intensity change of light source 1, to DC component in the output voltage from I/V converter 35 and a ratio of AC component, caused by the light intensity change of light source 1, to DC component in the output voltage from I/V converter 39. According to the present invention, the ratio of AC component, caused by the light intensity change of light source 1, to DC component in the output voltage from I/V converter 35 is so adjusted such that these ratios have the same amount.

The same adjustment as described above is made for each of the two other lights having different wavelengths. These adjustments are accomplished by AC/DC converters 45, 46 and 47 shown in FIG. 3. Thus, a ratio of AC component, caused by the light intensity change of light source 1, to DC component in the output voltages from AC/DC converter 45 is fixed substantially the same as a ratio of AC component, caused by the light intensity change of light source 1, to DC component in the output voltages from I/V converter 39. Similarly, a ratio of AC component, caused by the light intensity change of light source 1, to DC component in the output voltages from AC/DC converter 46 is fixed substantially the same as a ratio of AC component, caused by the light intensity change of light source 1, to DC component in the output voltages from I/V converter 40, and a ratio of AC component, caused by the light intensity change of light source 1, to DC component in the output voltages from AC/DC converter 47 is fixed substantially the same as a ratio of AC component, caused by the light intensity change of light source 1, to DC component in the output voltages from I/V converter 41.

In other words, AC/DC converter 45 produces a signal representing a ratio of AC component to DC component with respect to the light directly measured from light source 1 and having a wavelength of 805 nanometers. Other AC/DC converters 46 and 47 produce similar signals, but they are based on lights having wavelength of 710 nanometers and 650 nanometers.

Accordingly, logarithmic amplifiers 42, 43 and 44 produce signals having no noise signal caused by the light intensity change of light source 1.

Referring to FIG. 4, a circuit diagram of circuits 39-44 is shown. In the circuit shown in FIG. 4, the output currents from photoelectric cells 36, 37 and 38 are applied directly to a logarithmic compression circuits.

Logarithmic amplifier 42 has a transistor 48 which has its collector connected to the cathode side of photoelectric cell 36. Therefore, the collector current of transistor 48 is substantially the same as photocurrent I1 can be given by a product of a light intensity Iow of light at the wavelength 805 nanometers from light source 1 and the transmittance, or reflectance, of the body member. The light intensity Iow is a composite signal of DC component Iowdc and AC component Iown representing the noise signal caused by the light intensity change of light source 1, and therefore, the following equation may be obtained:

Iow=(Iowdc+Iown)F=Iowdc(1+Nw)F,

wherein ##EQU5## and F is a constant determined by the sensitivity of the photoelectric cell and transmittance of the body member. Since a photocurrent Ir from photoelectric cell 34 is proportional to the light intensity Io of light from light source 1 in every wavelength, and since Io has a DC component and AC component Ion caused by the light intensity change of light source 1, the following equation may be obtained:

Ir=K1(Iodc+Ion)=K1.times.Iodc(1+N),

wherein ##EQU6## and K1 is a constant. The output voltage Vr produced from I/V converter 35, which is coupled to photoelectric cell 34, can be given as follows:

Vr=Ro.times.K1.times.Iodc(1+N).

Thus, a current that flows through a resistor R1 may be written as follows: ##EQU7## and through a resistor R2, a current that has no AC component flows, which may be written as follows: ##EQU8## wherein R is equal to a value of a parallel connection of resistors R2 and R5. Thus, ##EQU9## Accordingly, the collector current of transistor 51 can be written as follows: ##EQU10## Therefore, logarithmic amplifier 42 produces an output voltage Vout which can be written as: ##EQU11## In the above equation, the first term