A monolithically integratable signal amplifier stage with high output dynamics includes first, second, and third bipolar NPN transistors and first and second current mirror circuits. The collector terminal of the first transistor is connected to the positive terminal of a supply voltage generator. The base terminal of the first transistor is in input terminal of the amplifier stage. The base terminals of the second and third transistors are connected to the emitter terminal of the first transistor, which is connected via first constant current generator to the negative terminal of the supply voltage generator. The second and third transistors also have their emitters connected to the negative terminal of the supply voltage generator. The input of the first current mirror circuit and the output of the second current mirror circuit are connected to the collector terminals of the third and second transistors. The output of the first current mirror circuit and the input of the second current mirror circuit are both connected via a second constant current generator to the negative terminal of the supply voltage generator.
Selective thyroid hormone agonists are disclosed that are highly selective for the TR.beta. subtype with high binding affinity. Methods of using such agonists and pharmaceutical compositions containing them are also disclosed, as are novel procedures for their preparation.
