N-octyl salicylic acid amide and N-decyl salicylic acid amide, a process for their production from salicylic acid methyl ester and a primary amine, and use of the amides in antimicrobial compositions.
The invention provides oil-soluble multivalent metal ion salts of a compound of the formula XNR.sup.1 R.sup.2, in which R.sup.1 and R.sup.2 are the same or different and each are selected from hydrogen and hydrocarbon based radicals having from 1 to 30 carbon atoms, X is an acyl radical of an aromatic ortho-hydroxy carbozxyic acid having a ring substituent which is a hydrocarbon based radical having at least 4 carbon atoms, a process for their preparation, and their use, as additives, in lubricating oils.
The present invention provides a fast, high yield method for preparing salicylamide intermediates. The method comprises reacting a C.sub.4 or higher alkyl ester of salicylic acid or derivative thereof with at least one amine selected from the group consisting of monoalkylamines, dialkylamines, ammonia, and any combination of any of the foregoing in alcohol to yield the salicylamide. The C.sub.4 or higher alkyl ester of salicylic acid or a derivative thereof is preferably prepared by reacting salicylic acid or a derivative thereof with a C.sub.4 or higher alcohol in presence of at least one of sulfuric acid, a sulfonic acid, and a mineral acid. This process for preparing salicylamide intermediates from salicylic acid or derivative thereof generally has a cycle time of about 2 days, and yields about 95% of a 99% pure material. In comparison, when a C.sub.3 or lower alkyl ester is used in lieu of the C.sub.4 or higher alkyl ester, the process generally has a cycle time of 7 9 days and yields about 60% of a 95% pure material. Methods of preparing an alkylated salicylamide are also provided.
The present invention relates to a method of preparing an alkylated salicylamide from a protected and activated salicylamide via a dicarboxylated salicylamide intermediate. The present invention also relates to dicarboxylic salicylamide delivery agent compounds for the delivery of active agents. Methods of administration are provided as well.
The present invention relates to a method of preparing an alkylated salicylamide from a protected and activated salicylamide via a dicarboxylated salicylamide intermediate. The present invention also relates to dicarboxylic salicylamide delivery agent compounds for the delivery of active agents. Methods of administration are provided as well.
