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Method and apparatus for processing signals used in oximetry    
United States Patent4800495   
Link to this pagehttp://www.wikipatents.com/4800495.html
Inventor(s)Smith; Robert E. (Edmonds, WA)
AbstractThe present invention relates to the processing of signals containing information about the pulse rate and oxygen saturation of arterial blood flowing in tissue. These signals have a relatively periodic pulsatile component superimposed upon a varying baseline component. To determine the pulse rate and oxygen saturation from the signals, the positive peaks, negative peaks, and period of the signal must be determined. The present invention accomplishes this by first searching for a sustained positive sloping region of the signal. Then the first derivative of the signal with respect to time is analyzed and points on the signal before and after the occurrence of a slope reversal marked. If the slope at the first point is positive, the interval between the two points is searched for a maximum amplitude that is identified as a positive peak. After the occurrence of a negative sloping region of the signal, another pair of points are marked occurring before and after a subsequent slope reversal. The minimum amplitude of the signal between these points is then identified as a negative peak. For improved accuracy, these positive and negative peaks are then compared with waveform templates to determine whether the amplitude between the peaks falls within an allowable range and to determine whether the interval between the peaks likewise falls within an acceptable range. These ranges are adjustable in proportion to the amplitude and interval compared against them. In this manner, values for the positive peak, negative peak, and period of the signal can be determined with high reliability.
   














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Inventor     Smith; Robert E. (Edmonds, WA)
Owner/Assignee     Physio-Control Corporation (Redmond, WA)
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Publication Date     January 24, 1989
Application Number     06/897,750
PAIR File History     Application Data   Transaction History
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Litigation
Filing Date     August 18, 1986
US Classification     600/322 356/41 600/323 600/330
Int'l Classification     G06F 015/42
Examiner     Smith; Jerry
Assistant Examiner     Kibby; Steven G.
Attorney/Law Firm     Christensen, O'Connor, Johnson & Kindness
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Priority Data    
USPTO Field of Search     364/415 364/416 364/417 128/637 128/664 128/663 128/666 356/41
Patent Tags     processing signals used oximetry
   
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2706927



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3647299



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4453218
Sperinde
600/331
Jun,1984

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Wilber
600/330
Oct,1983

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Hamaguri
600/323
May,1981

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Haase
600/311
May,1980

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Nielsen
356/39
Sep,1979

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Jansen
600/494
Feb,1979

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Shaw
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Sep,1978

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Kofsky
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May,1978

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Takeuchi
324/76.33
Jul,1977

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Konishi
356/39
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Shaw
356/41
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Herczfeld
600/324
Dec,1972

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Dec,1969

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The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows:

1. An apparatus for processing a signal containing information about arterial blood flowing in tissue, said signal having a relatively periodic pulsatile component superimposed upon a varying baseline component, said apparatus comprising:

first portion identification means for identifying a first portion of said signal during which the sign of the slope of said signal changes from positive to negative;

positive peak location means for locating the point along said first portion of said signal having the largest amplitude, the point having said largest amplitude defining a positive peak of said signal;

second portion identification means for identifying a second portion of said signal during which the sign of the slope of said signal changes from negative to positive;

negative peak location means for locating the point along said second portion of said signal having the smallest amplitude, the point having said smallest amplitude defining a negative peak of said signal and the difference in signal amplitude between said positive peak and said negative peak defining a pulse amplitude; and

analyzing means, responsive to said positive and negative peak location means, for producing an output indicative of a characteristic of said arterial blood.

2. The apparatus of claim 1, wherein said first portion identification means and said second portion identification means further comprise:

derivative computation means for producing an indication of the first derivative of said signal with respect to time;

first marker means for identifying an initial point on said signal at which the absolute value of said indication crosses below a predetermined threshold; and

second marker means for identifying the point on said signal at which the absolute value of said indication first crosses back above said predetermined threshold.

3. The apparatus of claim 2, wherein said indication produced by said derivative computation means comprises an autonormalized convolution derivative of the signal determined in accordance with the relationship: ##EQU14## where: n is the sample time for which the autonormalized convolution derivative is determined;

j is a summation index;

V(j) is the amplitude of said signal at a sample time j; and

k is an integer used to define the range over which the samples are summed.

4. The apparatus of claim 3, wherein S(n) is determined for k equal to three.

5. The apparatus of claim 1, further comprising positive slope detection means for determining when said slope of said signal has been positive for some predetermined time, said first portion detection means being inhibited from identifying said first portion of said signal until said predetermined time has been exceeded.

6. The apparatus of claim 1, further comprising period determination means for determining the time interval occurring between said positive peak and said negative peak of said sample.

7. The apparatus of claim 1, wherein said first portion identification means, positive peak location means, second portion identification means and negative peak location means cooperatively produce a plurality of pairs of said positive and negative peaks.

8. The apparatus of claim 1, wherein said characteristic indicated by said output of said analyzing means includes pulse rate and oxygen saturation.

9. The apparatus of claim 1, further comprising rejection means for rejecting said positive and negative peaks when said peaks fail to satisfy a selection criterion.

10. The apparatus of claim 9, wherein said criterion comprises a pulse amplitude template defining an allowable pulse amplitude range, said rejection means rejecting said positive and negative peaks when said pulse amplitude is outside of said allowable pulse amplitude range.

11. The apparatus of claim 10, wherein said allowable pulse amplitude range is adjustable.

12. The apparatus of claim 11, wherein said allowable pulse amplitude range is initialized at a predetermined level.

13. The apparatus of claim 11, wherein said allowable pulse amplitude range is automatically increased in porportion to said pulse amplitude when said pulse amplitude is outside of said allowable range and decreased in portion to said pulse amplitude when said pulse amplitude is within said allowable range.

14. The apparatus of claim 10, wherein said criterion further comprises a systolic interval template, the time between said positive peak and said negative peak defining a systolic interval, said systolic interval template defining an allowable systolic interval range, said rejection means rejecting said positive and negative peaks when said systolic interval is outside of said allowable systolic interval range.

15. The apparatus of claim 9, wherein said criterion comprises a systolic interval template, the time between said positive peak and said negative peak defining a systolic interval, said systolic interval template defining an allowable systolic interval range, said rejection means rejecting said positive and negative peaks when said systolic interval is outside of said allowable systolic interval range.

16. The apparatus of claim 15, wherein said allowable systolic interval range is adjustable.

17. The apparatus of claim 16, wherein said allowable systolic interval range is initialized at a predetermined level.

18. The apparatus of claim 16, wherein said allowable systolic interval range is increased in proportion to said systolic interval when said systolic interval is outside of said allowable systolic interval range and decreased in proportion to said systolic interval when said systolic interval is within said allowable range.

19. The apparatus of claim 9, further comprising means for comparing an average of said pulse amplitudes determined at a first and third pulse with an average determined at a second and fourth pulse, said first, second, third and fourth pulses being consecutive pulses of said arterial blood flowing in said tissue.

20. The apparatus of claim 1, further comprising means for band-limiting said signals.

21. The apparatus of claim 1, further comprising a differential, current-to-voltage amplifier for amplifying said signals.

22. A method for processing a signal containing information about arterial blood flowing in tissue, said signal having a relatively periodic pulsatile component superimposed upon a varying baseline component, said method comprising the steps of:

identifying a first portion of said signal during which the sign of the slope of said signal changes from positive to negative;

locating the point along said first portion of said signal having the largest amplitude, the point having said largest amplitude defining a positive peak of said signal;

identifying a second portion of said signal during which the sign of the slope of said signal changes from negative to positive;

locating the point along said second portion of said signal having the smallest amplitude, the point having said smallest amplitude defining a negative peak of said signal and the difference in signal amplitude between said positive peak and said negative peak defining a pulse amplitude; and

producing an output indicative of a characteristic of said arterial blood in response to said positive and negative peaks.

23. The method of claim 22, wherein said step of identifying said first and second portions of said signal further comprises the steps of:

producing an indication of the first derivative of said signal with respect to time;

identifying an initial point on said signal at which the absolute value of said indication crosses below a predetermined threshold; and

identifying the point on said signal at which the absolute value of said indication first crosses back above said predetermined threshold.

24. The method of claim 23, wherein said step of producing an indication of the first derivative of said signal with respect to time comprises producing an autonormalized convolution derivative of the signal determined in accordance with the relationship: ##EQU15## where: n is the sample time for which the autonormalized convolution derivative is determined;

j is a summation index;

V(j) is the amplitude of said signal at a sample time j; and

k is an integer used to define the range over which the samples are summed.

25. The method of claim 24, wherein S(n) is determined for k equal to three.

26. The method of claim 22, further comprising the step of determining when said slope of said signal has been positive for some predetermined time before said step of identifying said first portion of said signal is performed.

27. The method of claim 22, further comprising the step of determining the time interval occurring between said positive peak and said negative peak of said sample.

28. The method of claim 22, wherein said steps of identifying said first portion of said signal, locating the point along said first portion of said signal having the largest amplitude, identifying said second portion of said signal, and locating the point along said second portion of said signal having the smallest amplitude cooperatively produce a plurality of pairs of said positive and negative peaks.

29. The method of claim 22, wherein said characteristic of said arterial blood flow indicated by said output includes pulse rate and oxygen saturation.

30. The method of claim 22, further comprising the step of rejecting the positive and negative peaks when said peaks fail to satisfy a selection criterion.

31. The method of claim 30, wherein said criterion comprises a pulse amplitude template defining an allowable pulse amplitude range, said positive and negative peaks being rejected when said pulse amplitude is outside of said allowable pulse amplitude range.

32. The method of claim 31, wherein said allowable pulse amplitude range is adjustable.

33. The method of claim 32, wherein said allowable pulse amplitude range is initialized at a predetermined level.

34. The method of claim 32, wherein said allowable pulse amplitude range is automatically increased in proportion to said pulse amplitude when said pulse amplitude is outside of said allowable range and decreased in proportion to said pulse amplitude when said pulse amplitude is within said allowable range.

35. The method of claim 31, wherein said criterion further comprises a systolic interval template, the time between said positive peak and said negative peak defining a systolic interval, said systolic interval template defining an allowable systolic interval range, said positive and negative peaks being rejected when said systolic interval is outside of said allowable systolic interval range.

36. The method of claim 30, wherein said criterion comprises a systolic interval template, the time between said positive peak and said negative peak defining a systolic interval, said systolic interval template defining an allowable systolic interval range, said positive and negative peaks being rejected when said systolic interval is outside of said allowable systolic interval range.

37. The method of claim 36, wherein said allowable systolic interval range is adjustable.

38. The method of claim 37, wherein said allowable systolic interval range is initialized at a predetermined level.

39. The method of claim 37, wherein said allowable systolic interval range is increased in proportion to said systolic interval when said systolic interval is outside of said allowable systolic interval range and decreased in proportion to said systolic interval when said systolic interval is within said allowable range.

40. The method of claim 30, further comprising the step of comparing an average of said pulse amplitudes determined at a first and third pulse with an average determined at a second and fourth pulse, said first, second, third and fourth pulses being consecutive pulses of said arterial blood flowing in said tissue.

41. The method of claim 22, further comprising the step of band-limiting said signals.

42. An apparatus for processing a signal containing information about arterial blood, said signal having a relatively periodic pulsatile component superimosed upon a variable baseline component, said apparatus comprising:

positive peak identification means for employing an autonormalized convolution derivative of said signal to identify a positive peak of said signal;

negative peak identification means for employing an autonormalized convolution derivative of said signal to identify a negative peak of said signal; and

analyzing means, responsive to said positive and negative peak idenfication means, for producing an output indicative of a characteristic of said arterial blood.

43. A method of processing a signal containing information about arterial blood, said signal having a relatively periodic pulsatile component superimposed upon a variable baseline component, said method comprising the steps of:

determining the autonormalized convolution derivative of said signal;

employing said autonormalized convolution derivative to identify a positive peak of said signal and a negative peak of said signal; and

producing an output indicative of a characteristic of said arterial blood in response to said positive and negative peaks.
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BACKGROUND OF THE INVENTION

This invention relates to oximetry and, more particularly, to signal-processing techniques employed in oximetry.

The arterial oxygen saturation and pulse rate of an individual may be of interest for a variety of reasons. For example, in the operating room up-to-date information regarding oxygen saturation can be used to signal changing physiological factors, the malfunction of anaesthesia equipment, or physician error. Similarly, in the intensive care unit, oxygen saturation information can be used to confirm the provision of proper patient ventilation and allow the patient to be withdrawn from a ventilator at an optimal rate.

In many applications, particularly including the operating room and intensive care unit, continual information regarding pulse rate and oxygen saturation is important if the presence of harmful physiological conditions is to be detected before a substantial risk to the patient is presented. A noninvasive technique is also desirable in many applications, for example, when a home health care nurse is performing a routine check-up, because it increases both operator convenience and patient comfort. Pulse transmittance oximetry is addressed to these problems and provides noninvasive, continual information about pulse rate and oxygen saturation. The information produced, however, is only useful when the operator can depend on its accuracy. The method and apparatus of the present invention are, therefore, directed to the improved accuracy of such information without undue cost.

As will be discussed in greater detail below, pulse transmittance oximetry basically involves measurement of the effect arterial blood in tissue has on the intensity of light passing therethrough. More particularly, the volume of blood in the tissue is a function of the arterial pulse, with a greater volume present at systole and a lesser volume present at diastole. Because blood absorbs some of the light passing through the tissue, the intensity of the light emerging from the tissue is inversely proportional to the volume of blood in the tissue. Thus, the emergent light intensity will vary with the arterial pulse and can be used to indicate a patient's pulse rate. In addition, the absorption coefficient of oxyhemoglobin (hemoglobin combined with oxygen, HbO.sub.2) is different from that of deoxygenated hemoglobin (Hb) for most wavelengths of light. For that reason, differences in the amount of light absorbed by the blood at two different wavelengths can be used to indicate the hemoglobin oxygen saturation, % SaO.sub.2 (OS), which equals ([HbO.sub.2 ]/([Hb]+[HbO.sub.2 ])).times.100%. Thus, measurement of the amount of light transmitted through, for example, a finger can be used to determine both the patient's pulse rate and hemoglobin oxygen saturation.

As will be appreciated, the intensity of light transmitted through a finger is a function of the absorption coefficient of both "fixed" components, such as bone, tissue, skin, and hair, as well as "variable" components, such as the volume of blood in the tissue. The intensity of light transmitted through the tissue, when expressed as a function of time, is often said to include a DC component, representing the effect of the fixed components on the light, and an AC pulsatile component, representing the effect that changing tissue blood volume has on the light. Because the attenuation produced by the fixed tissue components does not contain information about pulse rate and arterial oxygen saturation, the pulsatile signal is of primary interest. In that regard, many of the prior art transmittance oximetry techniques eliminate the DC component from the signal analyzed.

For example, in U.S. Pat. No. 2,706,927 (Wood) measurements of light absorption at two wavelengths are taken under a "bloodless" condition and a "normal" condition. In the bloodless condition, as much blood as possible is squeezed from the tissue being analyzed. Then, light at both wavelengths is transmitted through the tissue and absorption measurements made. These measurements indicate the effect that all nonblood tissue components have on the light. When normal blood flow has been restored to the tissue, a second set of measurements is made that indicates the influence of both the blood and nonblood components. The difference in light absorption between the two conditions is then used to determine the average oxygen saturation of the tissue, including the effects of both arterial and venous blood. As will be readily apparent, this process basically eliminates the DC, nonblood component from the signal that the oxygen saturation is extracted from.

For a number of reasons, however, the Wood method fails to provide the necessary accuracy. For example, a true bloodless condition is not practical to obtain. In addition, efforts to obtain a bloodless condition, such as by squeezing the tissue, may result in a different light transmission path for the two conditions. In addition to problems with accuracy, the Wood approach is both inconvenient and time consuming.

A more refined approach to pulse transmittance oximetry is disclosed in U.S. Pat. No. 4,086,915 (Kofsky et al.). The Kofsky et al. reference is of interest for two reasons. First, the technique employed automatically eliminates the effect that fixed components in the tissue have on the light transmitted therethrough, avoiding the need to produce bloodless tissue. More particularly, as developed in the Kofsky et al. reference from the Beer-Lambert law of absorption, the derivatives of the intensity of the light transmitted through the tissue at two different wavelengths, when multiplied by predetermined pseudocoefficients, can be used to determine oxygen saturation. Basic mathematics indicate that such derivatives are substantially independent of the DC component of the intensity. The pseudocoefficients are determined through measurements taken during a calibration procedure in which a patient first respires air having a normal oxygen content and, later, respires air of a reduced oxygen content. As will be appreciated, this calibration process is at best cumbersome.

The second feature of the Kofsky et al. arrangement that is of interest is its removal of the DC component of the signal prior to being amplified for subsequent processing. More particularly, the signal is amplified to allow its slope (i.e., the derivative) to be more accurately determined. To avoid amplifier saturation, a portion of the relatively large DC component of the signal is removed prior to amplification. To accomplish this removal, the signal from the light detector is applied to the two inputs of a differential amplifier as follows. The signal is directly input to the positive terminal of the amplifier. The signal is also passed through a low-resolution A/D converter, followed by a D/A converter, before being input to the negative terminal of the amplifier. The A/D converter has a resolution of approximately 1/10 that of the input signal. For example, if the signal is at 6.3 volts, the output of the A/D converter would be 6 volts. Therefore, the output of the converter represents a substantial portion of the signal, which typically can be used to approximate the DC signal level. Combination of that signal with the directly applied detector signal at the amplifier produces an output that can be used to approximate the AC signal. As will be readily appreciated, however, the process may be relatively inaccurate because the output of the A/D converter is often a poor indicator of the DC signal.

Another reference addressed to pulse transmittance oximetry is U.S. Pat. No. 4,407,290 (Wilber). In that reference, light pulses produced by LEDs at two different wavelengths are applied to, for example, an earlobe. A sensor responds to the light transmitted through the earlobe, producing a signal for each wavelength having a DC and AC component resulting from the presence of constant and pulsatile absorptive components in the earlobe. A normalization circuit employs feedback to scale both signals so that the DC nonpulsatile components of each are equal and the offset voltages removed. Decoders separate the two signals, so controlled, into channels A and B where lowpass filters remove the DC component from each. The remaining AC components of the signals are amplified and combined at a multiplexer prior to analog-to-digital (A/D) conversion. Oxygen saturation is determined by a digital processor in accordance with the following relationship.

U.S. Pat. No. 4,167,331 (Nielson) disclose another pulse transmittance oximeter. The disclosed oximeter is based upon the principle that the absorption of light by a material is directly proportional to the logarithm of the light intensity after having been attenuated by the absorber, as derived from the Beer-Lambert law. The oximeter employs light-emitting diodes (LEDs) to produce light at red infrared wavelengths for transmission through tissue. A photosensitive device responds to the light produced by the LEDs and attenuated by the tissue, producing an output current. That output current is amplified by a logarithmic amplifier to produce a signal having AC and DC components and containing information about the intensity of light transmitted at both wavelengths. Sample-and-hold circuits demodulate the red and infrared wavelength signals. The DC components of each signal are then blocked by a series bandpass amplifier and capacitors, eliminating the effect of the fixed absorptive components from the signal. The resultant AC signal components are unaffected by fixed absorption components, such as hair, bone, tissue, skin. An average value of each AC signal is then produced. The ratio of the two averages is then used to determine the oxygen saturation from empirically determined values associated with the ratio. The AC components are also used to determine the pulse rate: ##EQU1## wherein empirically derived data for the constants X.sub.1, X.sub.2, X.sub.3 and X.sub.4 is stored in the processor.

The removal of the DC component of the signal, as typically employed by prior art devices, leaves the AC pulsatile component substantially centered about zero. This makes it easier to identify the peaks in the pulsatile waveform corresponding to systole and diastole because they will have substantially the same absolute value at each pulse. When the signal being analyzed includes the slowly varying DC component, however, the change in the DC level between pulses may cause the voltage level associated with a particular feature of the pulsatile waveform to be continually increasing or decreasing. The extraction of information from a signal including both the AC and DC components is, therefore, more complicated.

In addition, it should be noted that undesirable complicating features may be present in the signal representation of the intensity of light transmitted through the tissue. For example, the blood flow in certain individuals may exhibit a secondary pressure wave following systole, known as a dicrotic notch, that causes the signal to include a pair of slope reversals that must be distinguished from the peaks associated with systole and diastole. This phenomena is not exhibited by all individuals and the morphology of the pressure wave may vary both between different individuals and during the course of monitoring the same individual. Other undesirable features to be rejected include those produced by movement of the sensor relative to the patient, 50 Hz and 60 Hz power source interference, 120 Hz fluorescent lighting interference, and electrosurgical interference.

The present invention is directed to the accurate extraction of information from such signals including both the AC and DC components in a manner substantially unaffected by the complicating factors noted above.

SUMMARY OF THE INVENTION

The invention discloses an apparatus for processing signals containing information about the pulse rate and oxygen saturation of arterial blood flowing in tissue. These signals have a relatively periodic pulsatile component superimposed upon a varying baseline component. The apparatus includes an identifier for identifying a first portion of the signal during which the sign of the signal's slope changes from positive to negative. A positive peak locater then searches the first portion of the signal to locate the point having the largest amplitude. This point is defined as the positive peak of the signal. Similarly, a second portion identifier is included to identify a second portion of the signal during which the sign of the signal's slope changes from negative to positive. A negative peak locater then examines the second portion of the signal to locate the point having the smallest amplitude. This point is defined as the negative peak of the signal. The difference in signal amplitude between the positive and negative peaks is defined as a phase amplitude.

In accordance with a particular aspect of the invention, the first portion and second portion identifiers include a derivative identifier for producing an output indicative of the first derivative of the signal with respect to time. A first marker then identifies an initial point on the signal at which the absolute value of that output crosses below a predetermined threshold. A second marker identifies the point on the signal at which the absolute value of the output first crosses back above the predetermined threshold. Preferably, the output produced by the derivative processor is the autonormalized convolution derivative of the signal determined in accordance with the relationship: ##EQU2## where n is the sample time for which the autonormalized convolution derivative is determined; j is a summation index;

V(j) is the amplitude of the signal at a sample time j; and

k is an integer used to define the range over which the samples are summed. Preferably, S(n) is determined for k equal to three.

In accordance with additional aspects of the invention, a positive slope detector is included to determine whether the slope of the signal has been positive for some predetermined time before a first portion of the signal is identified. The arrangement can be used to cooperatively produce a plurality of pairs of positive and negative peaks. A period analyzer can be included to determine the time interval occurring between the positive and negative peaks of the sample and an additional analyzer included to produce an output of the pulse rate and oxygen saturation from the positive and negative peak information.

In accordance with another aspect of the invention, a rejection apparatus is included that rejects positive and negative peaks when those peaks fail to satisfy a selection criterion. For example, the criterion may include a pulse amplitude template defining an allowable pulse amplitude range. Thus, when the pulse amplitude computed for the signal is outside of this allowable range, the positive and negative peaks producing that pulse amplitude are rejected. The allowable pulse amplitude range may be adjustable and initialized at a predetermined level. Preferably, the range is increased in proportion to the pulse amplitude when the pulse amplitude is outside of the range and decreased in proportion to the pulse amplitude when the pulse amplitude is within the allowable range. A comparator may also be included for comparing the average of the pulse amplitudes determined at a first and third pulse with an average determined at a second and fourth pulse.

The rejection criterion may also include a systolic interval template. This template defines an allowable systolic interval range for comparison to the time interval between the positive and negative peaks. If that systolic interval is outside of the allowable systolic interval range, the positive and negative peaks from which the systolic interval is determined are rejected. Preferably, the allowable systolic interval range is adjustable and initialized at a predetermined level. The allowable range may be increased in proportion to the systolic interval when the systolic interval is outside of the allowable range and decreased in proportion to the systolic interval when the systolic interval is within the allowable range.

As will be readily appreciated, the disclosed invention also is directed to the methods employed by the apparatus described above and in its broadest formulation includes the steps of identifying a first portion of the signal, during which the sign of the signal's slope changes from positive to negative, and locating the point along the first portion of the signal having the largest amplitude. Then a second portion of the signal is identified during which the sign of the signal's slope changes from negative to positive and the point along the second portion of the signal having the smallest amplitude is located. In this manner, positive and negative peaks are defined having a pulse amplitude defined therebetween.

BRIEF DESCRIPTION OF THE DRAWINGS

The invention can best be understood by reference to the following portion of the specification, taken in conjunction with the accompanying drawings in which:

FIG. 1 is a block diagram of an oximeter including a sensor, input/output (I/O) circuit, microcomputer, alarm, displays, power supply, and keyboard;

FIG. 2 is a block diagram illustrating the transmission of light through an absorptive medium;

FIG. 3 is a block diagram illustrating the transmission of light through the absorptive medium of FIG. 2, wherein the medium is broken up into elemental components;

FIG. 4 is a graphical comparison of the incident light intensity to the emergent light intensity as modeled in FIGS. 2;

FIG. 5 is a graphical comparison of the specific absorption coefficients for oxygenated hemoglobin and deoxygenated hemoglobin as a function of the wavelength of light transmitted therethrough;

FIG. 6 is a block diagram illustrating the transmission of light through a block model of the components of a finger;

FIG. 7 is a graphical comparison of empirically derived oxygen saturation measurements related to a variable that can be measured by the oximeter;

FIG. 8 is a schematic illustration of the transmission of light at two wavelengths through a finger in accordance with the invention;

FIG. 9 is a graphical plot as a function of time of the transmission of light at the red wavelength through the finger;

FIG. 10 is a graphical plot as a function of time of the transmission of infrared light through the finger;

FIG. 11 is a more detailed schematic of the I/O circuit illustrated in the system of FIG. 1;

FIG. 12 is a schematic diagram of a conventional current-to-voltage amplifier circuit;

FIG. 13 is a schematic diagram of a differential current-to-voltage preamplifier circuit included in the I/O circuit of FIG. 1;

FIG. 14 is a graphical representation of the possible ranges of the I/O circuit output showing the desired response of the I/O circuit and microcomputer at each of the various possible ranges;

FIG. 15 is a block diagram of a portion of the signal processing software included in the microcomputer illustrated in FIG. 1, showing band-limiting, data buffer, autonormalized convolution derivative (ANCD) processor, peak processor, waveform template comparator, template adaptor, and template descriptor blocks;

FIG. 16 is a more detailed block diagram of the band-limiting block shown in FIG. 15;

FIG. 17 is a graphical illustration of the signal received by the ANCD processor block of FIG. 15 as a function of time;

FIG. 18 is a table illustrating the output S(n) of the ANCD processor block at a plurality of sample times;

FIG. 19 is a graph representative of the output of the ANCD processor block over an interval corresponding to one pulse;

FIG. 20 is a more detailed block diagram of the ANCD processor block shown in FIG. 15;

FIGS. 21 through 25 are more detailed block diagrams of the peak processor bl