A liquid handling system includes flow network module structure that defines a contained array of flow channels and a plurality of valves for controlling liquid flow through the flow channel array. The flow network module structure is adapted to be connected to an external source for applying a pressure differential to the flow network array to produce liquid flow within passages of the array. Also incorporated in the flow network module is chamber structure that is connected to the flow channel array and that has port structure in an outer surface of the module structure. Valve structure on the module structure is movable between a first position in which the port structure is closed and a second position in which the port structure is opened, the valve structure including actuator structure for moving a valve member between the first and second positions. Liquid transfer structure, including transport structure and probe structure carried on the transport structure, is adapted to cause movement of the valve structure from its first position to its second position concurrently with the movement of the probe structure into alignment with the chamber port structure for delivery of a quantity of sample material to the sample chamber and subsequent flow through the flow network array for interaction with an auxiliary fluid and transfer to an associated utilization device under the influence of an external pressure source.
There are described an incubator and an analyzer using such, in which the evaporation caps of the test element holding means are caused to be raised at loading and unloading stations by a fixed camming surface and a cam follower on each of the caps. As a result, size and complexity of the incubator are substantially reduced.
There is disclosed a closure mechanism for two reagent bottles in a bottle holder of an analyzer, using a shutter that slideably and frictionally engages the top surface of grommets at the mouth of the bottles. The shutter slides to either an open or closed position of the bottles, either both in lock-step or with one bottle open, the other closed, and both closed together. The shutter is driven by a cam and cam followers, either rotationally or linearly.
A robotically manipulable sample handling tool, such as a colony picking head or robotic pipetting tool, includes needles arranged on the tool. Actuators may be associated with each needle to control flow for the needle, e.g., to move the needle and/or draw fluid into/expel fluid from the needle. The actuators may be arranged so that needles are individually controlled by a controller that outputs a number of control signals that is less than the total number of needles. The actuators may be membrane valves that receive two signals from a controller; a first signal that opens or closes the valve, and a second signal that causes fluid flow through the valve to actuate a needle.
A sample handling tool, such as a colony picking head or robotic pipetting tool, includes sample handling needles, e.g., capillaries, arranged on the tool. Actuators are associated with each capillary to control flow for the capillary, e.g., to move the capillary and/or draw fluid into/expel fluid from the capillary. The actuators are arranged so that capillaries may be individually controlled by a controller that is capable of outputting a number of control signals that is less than the total number of capillaries. The actuators may be valves that receive two signals from a controller, a first signal that opens or closes the valve, and a second signal that allows fluid to flow in the valve.
In an apparatus for fluid analysis, a plurality of reagent-mixture components are each injected by a respective pump through a valve matrix and into a flow-injection unit. The flow-injection unit defines a mixing chamber including a plurality of. As the reagent-mixture components are injected into the mixing chamber, the nubs agitate the fluid flow, thereby dispersing the reagent-mixture components and in turn mixing the components together to create a reagent mixture. The flow rates of the reagent-mixture components are adjusted in order to select the reagent-mixture ratio as the components are combined in the flow-injection unit to thereby create the selected reagent mixture. Upon passage through the flow-injection unit, the reagent-mixture is injected into a sensing unit for analyzing a particle distribution of the mixture.
