1,2,3,4-Tetrahydro-1,1,4,4-tetramethyl-6-(.alpha.-methylstyryl)naphthalene possesses antihyperplastic, antimetaplastic, antineoplastic tumor-preventative and tumor-therapeutic properties and can accordingly be used in the treatment of precancerous or premalignant lesions as well as in the treatment of malignant tumors of epithelial and mesenchymal nature.
Novel aromatic polycyclic retinoid-type derivatives of general formula (I), ##STR1## wherein groupings R.sub.3 and R.sub.4 attached to the double bond between carbons 11 and 12 are cis groupings, and pharmaceutical and cosmetic compositions containing same, are disclosed.
Compositions and methods for prevention of adhesion formation, whereby an effective amount of at least one retinoid, e.g., all trans retinoic acid, is administered for a period of time sufficient to permit tissue repair. The retinoid is preferably administered in conjunction with a delivery vehicle (e.g., microcapsules, microspheres, biodegradable polymer films, lipid-based delivery systems such as liposomes and lipid foams, viscous instillates and absorbable mechanical barriers) useful for maintaining local concentrations of the compound at the injury site at an effective level.
