September 5, 1989

An anticancer compound is disclosed which is represented by the formula ##STR1## wherein one of R.sup.1 and R.sup.2 is a phenyl-lower alkyl optionally having a substituent, phenyl-lower alkenyl or naphthyl-lower alkyl, the other of R.sup.1 and R.sup.2 is hydrogen or acyl, and R.sup.3 is hydrogen, acyl or tetrahydrofuranyl, or represented by the formula ##STR2## wherein R.sup.x is an optionally substituted pyridyl, Y is arylene and .alpha. is a known 5-fluorouracil derivative residue which can be converted to 5-fluorouracil in vivo and which is linked to the carbonyl by an ester or amide linkage.

20

September 5, 1989

06/903,824

September 3, 1986

536/28.55   514/274 514/50 544/310

C07D   405/12   (20060101)   C07D   405/14   (20060101)   C07D   405/04   (20060101)   C07D   405/00   (20060101)   C07D   213/00   (20060101)   C07D   213/69   (20060101)   A61K   31/505   (20060101)   C07D   409/00   (20060101)   C07D   213/85   (20060101)   C07D   213/80   (20060101)   C07D   409/12   (20060101)   C07F   7/00   (20060101)   C07D   401/12   (20060101)   C07D   401/00   (20060101)   C07F   7/18   (20060101)   C07H   19/06   (20060101)   C07H   19/00   (20060101)  

This application is a continuation-in-part of application Ser. No. 793,056 filed Oct. 30, 1985, now abandoned.

Oct 30, 1984 [JP] 59-229938 Nov 30, 1984 [JP] 59-254587 Jan 17, 1985 [JP] 60-7190 Mar 25, 1985 [JP] 60-59788 May 09, 1985 [JP] 60-98295 Aug 30, 1985 [JP] 60-192582 Sep 03, 1985 [JP] 60-195223 Jul 25, 1986 [JP] 61-176464 Jul 30, 1986 [JP] 61-181027

536/23  

	5512678 - 5-(1-fluoro-vinyl)-1H-pyrimidine-2,4-dione derivatives useful as antineoplastic agents - Owned by Merrell Pharmaceuticals Inc. (Cincinnati, OH) The present invention provides novel 5-(1-fluorovinyl)-1H-pyrimidine-2,4-dione derivatives which are useful as antineoplastic agents by themselves or in conjunctive therapy with the antineoplastic agent 5-fluorouracil.
	5869464 - 2'-Deoxy-5-fluorouridine derivatives, a process for their preparation, antitumor agents containing same and methods for using said agents - Owned by Taiho Pharmaceutical Co. Ltd. (Tokyo,JP) The compounds of the invention are a 2'-deoxy-5-fluorouridine derivative represented by the formula ##STR1## wherein one of R.sub.1 and R.sub.2 is a hydrogen atom or a group easily hydrolyzable in vivo, the other is a benzyl group which may optionally have at least one halogen atom or trifluoromethyl group as a substituent on the phenyl ring, and R.sub.3 is a lower alkyl group, and a pharmaceutically acceptable salt thereof. The compounds of the invention can be suitably used as an antitumor agent.
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	6235776 - Method for treating a patient with neoplasia by treatment with a paclitaxel derivative - Owned by Cell Pathways, Inc. (Horsham, PA) This invention provides a method for treating a patient with neoplasia by an adjuvant therapy that includes treatment with a paclitaxel derivative.