There are disclosed compounds of the formula: ##STR1## wherein X is --CH.sub.2 R; R is ##STR2## and further when Y=S, R may also be --(CH.sub.2).sub.e CH.sub.3 ; Y is --O--or --S--; R.sup.1 and R.sup.2 are each, independently, hydrogen or lower alkyl; R.sup.3 is indolyl, furyl, phenyl or phenyl optionally mono- or disubstituted independently by alkyl of 1-7 carbon atoms, --C(CH.sub.3).sub.3, --C(CH.sub.3).sub.2 CH.sub.2 C(CH.sub.3).sub.3, --C(CH.sub.3).sub.2 CH.sub.2 CH.sub.3, haloloweralkyl, perfluoroalkyl, lower alkoxy, aryl alkoxy, halo or nitro; R.sup.4 and R.sup.5 are, independently, --COCH.sub.2 R.sup.7, --CO.sub.2 R.sup.7, --CONHR.sup.7, geranyl or CH.sub.2 R.sup.3 ; R.sup.6 is hydrogen or lower alkyl; R.sup.7 is geranyl and any moiety selected from R other than ##STR3## A and B are, independently, --O--, --S-- or --NR.sup.6 --; and a is 0-8; b is 1-10 when Y=S, and 2-10 when Y=O; c is 1-3; d is 0-9; and e is 3-18; which by virtue of their ability to inhibit PLA.sub.2, are of use as antiinflammatory agents and there is also disclosed a method for the treatment of immunoinflammatory conditions, such as allergy, anaphylaxis, asthma and inflammation in mammals.

There are disclosed compounds of the formula: ##STR1## wherein X is O, S or NR; R is hydrogen or lower alkyl; R.sup.1 and R.sup.2 are each, independently, hydrogen, C.sub.1 -C.sub.10 alkyl, C.sub.3 -C.sub.20 cycloalkyl, phenylloweralkyl, or substituted phenylloweralkyl substituted by halo, lower alkyl, lower alkoxy, halo lower alkyl, amino, monoloweralkylamino, diloweralkylamino or sulfonamido; A is O, S, NR, or a chemical bond; m is 0-15; n is 0-20; p is 0-15, where m+p.ltoreq.15; and the pharmacologically acceptable salts thereof, which by virtue of their ability to inhibit PLA.sub.2, are of use as antiinflammatory agents and there is also disclosed a method for the treatment of immunoinflammatory conditions, such as allergy, anaphylaxis, asthma and inflammation in mammals, as well as in the modulation of PAF-mediated biological processes, such as embryonic implantation, thus making the compounds useful as antifertility agents.

There are disclosed compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen, alkyl, cycloalkyl, arylalkyl, --(CH.sub.2).sub.r CH.dbd.CH.sub.2, --(CH.sub.2).sub.s OY, --(CH.sub.2).sub.t CH(OZ)CH.sub.3, or Ar; X is O, S, or NR.sup.2 ; Y and Z are each, independently, hydrogen, alkyl, or --COR.sup.3 ; R.sup.2 and R.sup.3 are each, independently, hydrogen, alkyl, or arylalkyl; Ar is an aryl radical that may be optionally substituted; m=1-5; n=0-1; p=1-9; r=0-6; s=2-6; and t=0-6 or a pharmaceutically acceptable salt thereof which are useful as antiinflammatory agents.

There are disclosed compounds of the formula: ##STR1## wherein X is O; R.sup.1 and R.sup.2 are each, independently, hydrogen, C.sub.1 -C.sub.10 alkyl, C.sub.3 -C.sub.20 cycloalkyl, phenylloweralkyl, or substituted phenylloweralkyl substituted by halo, lower alkyl, lower alkoxy, halo lower alkyl, amino, monoloweralkylamino, diloweralkylamino or sulfonamido; A is O, S, NR, or a chemical bond; R, if present, is hydrogen or loweralkyl; m is 0-15; n is 3-12; p is 0-15, where m+p=2-15; and the pharmacologically acceptable salts thereof. Also disclosed is a method for treating immunoimmflammatory conditions in mammals which comprises administering to a mammal so afflicted an effective amount of a compound having the formula above wherein X, R.sup.1, R.sup.2, A, R, if present, m and p are as listed above and n=3-12 and m+p=2-15.

There are disclosed compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen, alkyl, cycloalkyl, arylalkyl, --(CH.sub.2).sub.r CH.dbd.CH.sub.2, --(CH.sub.2).sub.s OY, --(CH.sub.2).sub.t CH(OZ)CH.sub.3, or Ar; X is O, S, or NR.sup.2 ; Y and Z are each, independently, hydrogen, alkyl, or --COR.sup.3 ; R.sup.2 and R.sup.3 are each, independently, hydrogen, alkyl, or arylalkyl; Ar is an aryl radical that may be optionally substituted; m=1-5; n=0-1; p=1-9; r=0-6; s=2-6; and t=0-6 or a pharmaceutically acceptable salt thereof which are useful as antiinflammatory agents.