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Method and apparatus for detecting optical pulses    
United States Patent4911167   
Link to this pagehttp://www.wikipatents.com/4911167.html
Inventor(s)Corenman; James E. (Oakland, CA); Stone; Robert T. (Sunnyvale, CA); Boross; Andras (Fremont, CA); Briggs; Deborah A. (San Ramon, CA); Goodman; David E. (San Francisco, CA)
AbstractA method and apparatus for improving the calculation of oxygen saturation and other blood constituents by non-invasive pulse oximeters. The method and apparatus permit more accurate determination of blood flow by collecting time-measures of the absorption signal at two or more wavelengths and processing the collected time-measure to obtain composite pulsatile flow data from which artifacts have been filtered. The processing may occur in the time domain or in the frequency domain. In the preferred time domain embodiment, successive portions of periodic information are weighted and added together in synchrony to obtain the composite pulse information. In the preferred frequency domain embodiment, the time-measure is Fourier transformed into its spectral components to form the composite information. A new method and apparatus for correlating the heartbeat and optical pulse is provided whereby a product of the ECG R-wave and optical pulse signals corresponding to the same heartbeat is obtained, and one signal is time shifted relative to the other until a maximum waveform product corresponding to the heartbeat is determined.



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Drawing from US Patent 4911167
Method and apparatus for detecting optical pulses - US Patent 4911167 Drawing
Method and apparatus for detecting optical pulses
Inventor     Corenman; James E. (Oakland, CA); Stone; Robert T. (Sunnyvale, CA); Boross; Andras (Fremont, CA); Briggs; Deborah A. (San Ramon, CA); Goodman; David E. (San Francisco, CA)
Owner/Assignee     Nellcor Incorporated (Hayward, CA)
Patent assignment
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Publication Date     * March 27, 1990
Application Number     07/175,152
PAIR File History     Application Data   Transaction History
Image File Wrapper   Patent Term   Fees
Litigation
Filing Date     March 30, 1988
US Classification     600/324 600/500 600/513
Int'l Classification     A61B 005/02
Examiner     Sykes; Angela D.
Assistant Examiner    
Attorney/Law Firm     Isackson; Robert M.
Address
Parent Case     CROSS REFERENCE TO RELATED APPLICATIONS This application is a continuation-in-part application of copending and commonly assigned U.S. application Ser. No. 742,720, now U.S. Pat. No. 4,802,486, entitled Improved Method and Apparatus For Detecting Optical Pulses, filed June 7, 1985 in the names of James E. Corenman and David E. Goodman, which is a continuation of U.S. application Ser. No. 718,525, entitled Improved Method and Apparatus For Detecting Optical Pulses, filed Apr. 1, 1985 in the names of James E. Corenman and David E. Goodman, now abandoned. This invention relates to non-invasive pulse oximetry and specifically to an improvement on the method and apparatus for photoelectric determination of blood constituents disclosed in U.S. applications Ser. No. 742,720 and 718,525. This specification is accompanied by software appendices A and B.
Priority Data    
USPTO Field of Search     128/632 128/633 128/637 128/632 128/633 128/632 128/633 128/632 128/633 128/696 128/700 128/706 128/708
Patent Tags     detecting optical pulses
   
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We claim:

1. A method for calculating the amount of a blood constituent from the blood flow characteristics of a patient comprising:

detecting an absorption signal corresponding to the absorption of light measured at two or more wavelengths in the patient's tissue including periodic changes caused by periodic arterial pulses in the blood flow characteristics and aperiodic changes unrelated to the patient's heartbeat;

detecting an ECG signal corresponding to the patient's ECG waveform corresponding to the periodic electrical heart activity of the patient;

selecting a first time-measure of the absorption signal including a maximum and minimum amplitude change in absorption;

selecting a second time-measure of the ECG signal including components corresponding to the occurrence of the heartbeat;

correlating the ECG signal and the absorption signal by multiplying the first time-measure of the absorption signal and the second time-measure of the ECG signal together to form a waveform product and thereafter shifting the time-measure of the absorption signal backwards in time relative to the time-measure of the ECG signal and multiplying the shifted and unshifted waveforms together to identify a maximum waveform product corresponding to the product of the ECG signal corresponding to the occurrence of the heartbeat and the maximum amplitude of the absorption signal;

processing the absorption signal and the determined correlation to identify the periodic changes in the absorption signal associated with the determined maximum waveform product likely to correspond to arterial pulses in the patient's blood flow characteristics: and

calculating the amount of the blood constituent from the identified periodic changes in the absorption signal.

2. The method of claim 1 wherein the ECG signal further comprises the R-wave component of the ECG signal so that the maximum waveform product corresponds to the product of the R-wave component and the maximum of the absorption signal.

3. The method of claim 2 wherein the first time-measure is shorter in length than the second time-measure so that as the absorption signal time-measure is shifted backward relative to the ECG time-measure the latest maximum waveform product corresponds to the most recent heartbeat activity in the first and second time-measures.

4. The method of claim 3 wherein the first time-measure includes a first plurality of maximum amplitudes and the second time-measure includes a second plurality of R-wave signals so that the maximum waveform product further comprises an array of maximum waveform products.

5. Apparatus for calculating the amount of a blood constituent from the blood flow characteristics of a patient comprising:

means for photoelectrically detecting an absorption signal corresponding to the absorption of light measured at two or more wavelengths in the patient's tissue including periodic changes caused by periodic arterial pulses in the blood flow characteristics and aperiodic changes unrelated to the patient's heartbeat;

means for electrically detecting an ECG signal corresponding to the patient's ECG waveform corresponding to the periodic electrical heart activity of the patient;

means for selecting a first time-measure of the absorption signal including a maximum and minimum amplitude change in absorption;

means for selecting a second time-measure of the ECG signal including components corresponding to the occurrence of the heartbeat;

means for correlating the ECG signal and the absorption signal by multiplying the first time-measure of the absorption and the second time-measure of the ECG signal together to form a waveform product and thereafter shifting the time-measure of the absorption signal backwards in time relative to the time-measure of the ECG signal and multiplying the shifted and unshifted waveforms together to identify a maximum waveform product corresponding to the product of the ECG signal corresponding to the occurrence of the heartbeat and the maximum amplitude of the absorption signal;

means for processing the absorption signal and the determined correlation to identify the periodic changes in the absorption signal associated with the determined maximum waveform product likely to correspond to arterial pulses in the patient's blood flow characteristics; and

means for calculating the amount of the blood constituent from the identified periodic changes in the absorption signal.

6. The apparatus of claim 5 wherein the means for electrically detecting an ECG signal further comprises means for detecting the R-wave component of the ECG signal so that the maximum waveform product corresponds to the product of the R-wave component and the maximum of the absorption signal.

7. The apparatus of claim 6 wherein the first time-measure is shorter in length and later in time than the second time-measure so that as the absorption signal time-measure is shifted backwards relative to the ECG time-measure, the latest maximum waveform product corresponds to the most recent heartbeat activity in the first and second time-measures.

8. The apparatus of claim 7 wherein the first time-measure includes a first plurality of maximum amplitudes and the second time-measure includes a second plurality of R-wave signals so that the maximum waveform product further comprises an array of maximum waveform products.

9. A method for calculating the amount of a blood constituent from a patient's blood flow characteristics including aperiodic information corresponding to artifacts and periodic information corresponding to arterial pulses, comprising:

detecting a set of first signals representing the absorption of light measured at two or more wavelengths of light in the patient's tissue including detected information corresponding to changes in absorption as a result of changes in the blood flow characteristics;

detecting a second signal representing the occurrences of a selected portion of the ECG waveform of the patient;

processing the first and second signals to enhance the periodic information contained in each individual signal whereby the first signals are processed in a repetitive manner, one discrete portion at a time, and the occurrence of a selected portion of the patient's ECG waveform in the second signal initiates processing of a discrete portion of the first signals; and

calculating the amount of blood constituent using the enhanced periodic information in the processed portions of the first signals.

10. The method of claim 9 wherein processing the first and second signals further comprises correlating the discrete portions of the first signals and the occurrences of a selected portion of the patient's ECG waveform in the second signals.

11. The method of claim 10 wherein detecting the second signal further comprises detecting a signal representing the occurrences of the R wave portion of the ECG waveform of the patient.

12. The method of claim 11 wherein processing the first and second signals further comprises determining whether or not the detected information in the portions of the first signals are likely to be arterial pulses by using the determined correlation and preferentially processing detected information determined likely to be arterial pulses for use in calculating blood constituents.

13. The method of claim 12 wherein preferentially processing detected information further comprises rejecting detected information determined not likely to be arterial pulses so that rejected information is not used in calculating the blood constituent.

14. The method of claim 12 wherein processing the first and second signals further comprises determining whether or not detected information in a discrete portion of the first signals is likely to be an arterial pulse by using the determined correlation after each occurrence of an R wave portion in the second signal.

15. The method of claim 11 wherein correlating the first and second signals further comprises:

determining a period of time after the occurrence of an R wave in which detected information in the portions of the first signals corresponding to blood flow characteristic changes caused by arterial pulses are likely to be detected;

determining that detected signal information in the discrete portions of the first signals are likely to be arterial pulses when detected in the determined period of time after the occurrence of an R wave; and

calculating the blood constituents further comprises preferentially processing any determined detected information for use in calculating blood constituents.

16. The method of claim 15 wherein preferentially processing detected information further comprises rejecting detected information detected other than in the determined period of time after the R wave occurs so that rejected information is not used in the calculation of blood constituents.

17. The method of claim 15 wherein determining whether or not detected information in a discrete portion of the first signals is acceptable for preferential processing as corresponding to an arterial pulse by using the determined correlation after each occurrence of an R wave portion in the second signal.

18. The method of claim 11 wherein calculating the amount of blood constituent further comprises calculating oxygen saturation of hemoglobin in arterial blood.

19. The method of claim 10 wherein correlating the first and second signals further comprises:

synchronizing the occurrence of a plurality of discrete portions of the first signals;

synchronizing the occurrence of a plurality of occurrences of the R wave portion in the second signal; and

correlating the synchronized discrete portions of the firs signals and the R wave portions.

20. Apparatus for calculating the amount of a blood constituent from a patient's blood flow characteristics including arterial pulses and artifacts comprising:

means or photoelectrically detecting a set of first signals representing the absorption of light measured at two or more wavelengths in the patient's tissue including detected information corresponding to changes in absorption as a result of changes in the blood flow characteristics;

means for detecting a second signal representing the occurrences of a selected portion of the patient's ECG waveform;

means for processing the first and second signals to enhance the periodic information contained in each individual signal whereby each occurrence of a selected portion in the second signal initiates processing of a discrete portion of the first signals so that the information in the first signals are processed in a repetitive manner; and

means for calculating the amount of blood constituent using the enhanced information in the processed portions of the first signals.

21. The apparatus of claim 20 wherein the means for processing the first and second signals further comprises means for correlating the discrete portions of the first signals with the occurrences of a selected portion of the patient's ECG waveform in the second signal.

22. The apparatus of claim 21 wherein the means for detecting a second signal further comprises means for detecting a signal corresponding to the occurrences of the R wave portion of the patient's ECG waveform.

23. The apparatus of claim 21 wherein the processing means further comprises:

means for determining whether or not the detected information in the discrete portions of the first signals are likely to be arterial pulses using the determined correlation; and

means for preferentially processing detected information determined likely to be arterial pulses for use in calculating blood constituents.

24. The apparatus of claim 23 wherein the means for preferentially processing detected information further comprises means for rejecting detected information determined not likely to be arterial pulses so that rejected information is not used in calculating blood constituents.

25. The apparatus of claim 23 wherein the processing means further determines whether or not detected information in a discrete portion of the first signals is likely to be an arterial pulse using the determined correlation after each occurrence of an R