There is described a process for preparing proanthocyanidine A2 by extraction from cortex or fruits of Aesculus hippocastanum and related species and its activity for stimulating healing processes, e.g. healing wounds and injuries of various origins, gastric and duodenal ulcers for modifying conditions of impaired capillary permeability and resistance and for obtaining an anti-lipid peroxidation effect. There are also described pharmaceutical formulations suitable for use by topical and systemic routes.
A method for preventing and/or reducing the toxicity of acetaminophen is disclosed. An amount of grape seed proanthocyanidin extract effective to inhibit toxicity of acetaminophen is administered before, simultaneous with, and/or after dosage of acetaminophen. This allows for increased therapeutic dosages of acetaminophen to be administered with reduced risk of toxic effects, and for prevention of toxic effects in people with special sensitivity to acetaminophen. A composition containing both acetaminophen and grape seed proanthocyanidin extract, allowing for ease of administration of an amount of grape seed proanthocyanidin extract effective to protect from toxicity, also is disclosed.
A method is disclosed for preventing and/or reducing stress-induced gastric injury by administering an amount of grape seed proanthocyanidin extract effective to inhibit injury is administered to persons identified as among those with or at risk for such injury.
A method and composition for topically administering ascorbic acid and proanthocyanidine for application to human skin care. The substance is composed of 10% to 25% ascorbic acid and at least 0.5% to 5% proanthocyanidine in combination with a high ratio water surfactant. Non-irritating thickeners, preservatives and carriers synergize to allow penetration of a serum composition to access the entire dermal membrane. The composition possesses sunscreen properties and superior collagen repair means.
The present invention relates to oral compositions containing cranberries or parts of cranberries, such as cranberry extract, or a mixture of such materials and other antibacterial/antimicrobial agents. The invention also relates to methods of treating plaque/gingivitis and other periodontal diseases as well as dental calculus and caries.
