July 3, 1990

The invention concerns the use of avarol and its derivatives and pharmaceutical compositions thereof for the control of AIDS and AIDS-related Complex (ARC).

2

July 3, 1990

07/058,200

June 4, 1987

514/729  

A61K   31/05   (20060101)   A61K   31/12   (20060101)   A61K   31/135   (20060101)   A61K   31/045   (20060101)   A61K   31/22   (20060101)   A61K   31/21   (20060101)  

This application is a continuation-in-part of prior-filed copending application Ser. No. 820,440, filed Jan. 17, 1986, presently still pending.

Jun 07, 1986 [DE] 3619202

514/729  

	6075057 - Inhibition of carbohydrates metabolism by quinone compounds - Owned by The University of Virginia Patent Foundation (Charlottesville, VA) Optically pure enantiomers of avarol are obtained. The enantiomers of avarol are demonstrated to be highly effective inhibitors of .alpha.-glucosidase and .alpha.-mannosidase. Other enzymes assayed were not inhibited by these optically pure compounds. Inhibition of these two enzymes is useful for a variety of assays and probes, and offers particular utility in the treatment of retroviral infection-associated syndromes, such as AIDS.
	5164376 - Method for treating retroviral infections with aryl-(2-pyrryl) keytone compound - Owned by Hoffmann-LaRoche Inc. (Nutley, NJ) A method for treating viral infections in a patient with aryl-(2-pyrryl) ketone compound and compositions.
	5141735 - Substituted amino-benzodiazepines having anitviral activity - Owned by Hoffman-La Roche, Inc. (Nutley, NJ) Novel substituted 2-amino-5-(1H-pyrrol-2-yl)-3H-1,4-benzodiazepines and compositions containing same for treatment and prophylaxis of viral infections, including HIV infections.